DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PEX6 and Pex6

DIOPT Version :9

Sequence 1:	NP_171799.2	Gene:	PEX6 / 839315	AraportID:	AT1G03000	Length:	941	Species:	Arabidopsis thaliana
Sequence 2:	NP_001027403.2	Gene:	Pex6 / 3772165	FlyBaseID:	FBgn0033564	Length:	899	Species:	Drosophila melanogaster

Alignment Length:	889	Identity:	264/889 - (29%)
Similarity:	412/889 - (46%)	Gaps:	205/889 - (23%)

- Green bases have known domain annotations that are detailed below.

plant   120 EDASLTQVPVSDSL----HTML--VFPTYDLMGQQLLDQEVAYLSPMLAFNLSLHISCLKSLVHR 178
            ::.::||..:...|    ||::  :.|........|..||..|
  Fly   142 DEGNMTQTVIKQMLQEAPHTIVAQILPAAQCQPNCLYVQENFY---------------------- 184

plant   179 GNGVLEKY-FEAKC--------DEEFIGKSAEDGSKIGLDLEPVSQVPGYASHLRVSFVKIPECG 234
            || :|::: ..:.|        ||:                    .:||.|:...|..|..|.
  Fly   185 GN-ILDRFQIRSNCWVQVEHFADEQ--------------------TIPGIATKAHVYLVADPH-- 226

plant   235 TIPSLKVNSSFEAEERQGLIDSALQKYFGTDRQLSRGDIFRIYIDWNCGSSICNPCSQR---LCS 296
                     ...||    |.:..|..||.|.|.:.||..:||.::    :.:....:..   |..
  Fly   227 ---------ELPAE----LTEVILSNYFNTPRLMHRGHTYRIEVN----AELVGTATYAHYYLIF 274

plant   297 ESDDYIYFKVIAMEPSNERF---------------LRVNHS------QTALVLGGTVSSGLPPDL 340
            ....:::.|.|.:|.....|               :..:||      ..::.:.....|||....
  Fly   275 AHLRHVHLKCIHLETKGSEFELQAIVAKNFSNLVQVPASHSFLPRQVLDSMAIVENYPSGLRKPY 339

plant   341 LVYRSKVPMPLQEETVNILASVLSPPLCPSALASKLRVAVLLHGIPGCGKRTVVKYVARRLGLHV 405
            .:.||.|...|.:::..:.:..:.|             ..||.|..|.||..:|..||:.||:|:
  Fly   340 KLLRSSVDAFLPKKSACLSSKHIFP-------------VFLLQGERGSGKSKLVSAVAQELGMHI 391

plant   406 VEFSCHSLLASSERKTSTALAQTFNMARRYSPTILLLRHFDVF--KNLGSQDGSLGDRVGVSFEI 468
            ....|..:::.....|...|...|..::...|.::...:|::|  .|.|::|          ..:
  Fly   392 YGADCAEIVSQVPSHTEMKLKAVFAKSQVCEPLMICFHNFEIFGIDNEGNED----------LRL 446

plant   469 ASVIRELTEPVSNGDSSMEEKSNSNFSENEVGKFRGHQVLLIASAESTEGISPTIRRCFSHEIRM 533
            .|......:.:.|.|                   |.|.::::| ..|...:.|.|:..|...|.:
  Fly   447 LSAFHVQVQELFNRD-------------------RKHPIVVVA-LTSDRHLKPMIQGLFLEIINI 491

plant   534 GSLNDEQRSEML---------------SQSLQGVSQFLNISSDEFM--------------KGLVG 569
            ...:.|:|.|:|               .::::.:..|...:..:||              :.:..
  Fly   492 DMPSKEERFEILRWMHVRETFNDIIYNQKAIEQLPLFSRENQSQFMPRISPSWRETLNVLQDVAA 556

plant   570 QTSGFLPRDLQALVADAGANLYISQESETKKINSLSDDLHGVDIHQASQIDNSTEKLTAKEDFTK 634
            ::.|||..|||.|..:|                        |.:...:::..:|..::   .|.|
  Fly   557 KSQGFLLGDLQLLYDNA------------------------VRMKIRNRLGRTTLDMS---HFAK 594

plant   635 ALDRSKKRNASALGAPKVPNVKWDDVGGLEDVKTSILDTVQLPLLHKDLFSSGLRKRSGVLLYGP 699
            .|...:...|.:|||||||.|.|.|:|||..:|..|..::.|||.|..|....|| |||:|||||
  Fly   595 NLTDMQSSFADSLGAPKVPKVYWSDIGGLAKLKDEIQSSIGLPLKHVHLMGKNLR-RSGILLYGP 658

plant   700 PGTGKTLLAKAVATECSLNFLSVKGPELINMYIGESEKNVRDIFEKARSARPCVIFFDELDSLAP 764
            |||||||:||||||||:|:||||:||||:|||:|:||:|||::|.:||||.|||:|.||||||||
  Fly   659 PGTGKTLVAKAVATECNLSFLSVQGPELLNMYVGQSEQNVREVFSRARSAAPCVLFLDELDSLAP 723

plant   765 ARGASGDSGGVMDRVVSQMLAEIDGLS--DSSQDLFIIGASNRPDLIDPALLRPGRFDKLLYVGV 827
            .||.:|||||||||||||:|||:||:|  |:|:.:||:.|:|||||||||||||||||||.|||.
  Fly   724 NRGVAGDSGGVMDRVVSQLLAEMDGMSDGDTSKPIFILAATNRPDLIDPALLRPGRFDKLFYVGP 788

plant   828 NADASYRERVLKALTRKFKLSEDVSLYSVAKKCPSTFTGADMYALCADAWFQAAKRKVSKSDSGD 892
            .:.|..:..||:|.|::|.|...|.:..:|::..|..:|||:|::|::||..|.:|.:....||.
  Fly   789 CSTAEDKAAVLRAQTQRFALDAGVDMEQIAERLKSEMSGADLYSICSNAWLSAVRRTIDGHLSGT 853

plant   893 MPTEEDDPDSVVVEYVDFIKAMDQLSPSLSITELKKYEMLRDQF 936
            :..:|..|::|:|:..||.|:.::..||:|..:|:.:..|:..:
  Fly   854 ISEKELVPENVIVQEEDFTKSFNKFVPSISAKDLEYFNNLKASY 897

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PEX6	NP_171799.2	CDC48	<380..937	CDD:273521	215/590 (36%)
PEX6	NP_171799.2	RecA-like_PEX6_r2	666..825	CDD:410935	112/160 (70%)
Pex6	NP_001027403.2	SpoVK	367..847	CDD:223540	201/537 (37%)
		P-loop_NTPase	367..492	CDD:304359	33/154 (21%)
		AAA	653..787	CDD:278434	101/133 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	218	1.000	Domainoid score	I733
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	358	1.000	Inparanoid score	I599
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D233419at2759
OrthoFinder	1	1.000	-	-		FOG0004626
OrthoInspector	1	1.000	-	-		oto2820
orthoMCL	1	0.900	-	-		OOG6_103617
Panther	1	1.100	-	-	LDO	PTHR23077
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3235
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.970