DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TTC29 and ttc29

DIOPT Version :9

Sequence 1:	NP_001287690.1	Gene:	TTC29 / 83894	HGNCID:	29936	Length:	501	Species:	Homo sapiens
Sequence 2:	XP_002938976.1	Gene:	ttc29 / 100498272	XenbaseID:	XB-GENE-992354	Length:	488	Species:	Xenopus tropicalis

Alignment Length:	482	Identity:	234/482 - (48%)
Similarity:	334/482 - (69%)	Gaps:	9/482 - (1%)

- Green bases have known domain annotations that are detailed below.

Human    27 MTTLPPLP-MTRPKLTALARQ-KLPCSSRKIPRS-----QLIKEKDDIDHYLEVNFKGLSKEEVA 84
            |:.:|.:| .:..:..:|..| |:|...:::|:.     .||:::...||..:.|.|.|||||.|
Frog     1 MSAVPAMPRQSLQRFPSLVHQRKVPAQPKELPQKANYKIHLIRDRGVRDHNQQKNIKELSKEETA 65

Human    85 AYRNSYKKNICVDMLRDGYHKSFTELFALMERWDALREAARVRSLFWLQKPLEEQPDKLDYLYHY 149
            .||||.|.|||::|||.||||||:|::.:::||||||:||...|..|.|||||||.:|||.|.|:
Frog    66 IYRNSLKNNICIEMLRKGYHKSFSEVYTVIQRWDALRDAAGPGSAIWHQKPLEEQQEKLDQLQHF 130

Human   150 LTRAEDAERKESFEDVHNNLYALACYFNNSEDKWVRNHFYERCFKIAQLIKIDCGKKEAEAHMHM 214
            |||||.|:|...:|:|:.|..|||.||....|.|:..||:|.||:.|..||:|.|:||||||.::
Frog   131 LTRAEAAQRAGYYEEVYENQLALAQYFQEVGDDWLSYHFFECCFQTATKIKMDGGRKEAEAHSNI 195

Human   215 GLLYEEDGQLLEAAEHYEAFHQLTQGRIWKDETGRSLNLLACESLLRTYRLLSDKMLENKEYKQA 279
            |.:.||.|||.:||||||||:.||.|||||||||||.|.||||:|.|.|.|.|||||.|||.:||
Frog   196 GSVEEEHGQLEKAAEHYEAFYHLTVGRIWKDETGRSHNSLACENLWRIYTLQSDKMLANKECQQA 260

Human   280 IKILIKASEIAKEGSDKKMEAEASYYLGLAHLAAEEYETALTVLDTYCKISTDLDDDLSLGRGYE 344
            ||.||||.::|:||.:||:|.||:|.|||||:::...:||:|.|:||.:||..|:|::|||:.|:
Frog   261 IKTLIKAFDMAREGGNKKLEGEAAYRLGLAHISSGNPQTAITYLNTYMEISKMLEDNVSLGKAYK 325

Human   345 AIAKVLQSQGEMTEAIKYLKKFVKIARNNFQSLDLVRASTMLGDIYNEKGYYNKASECFQQAFDT 409
            |:||.|:|||::.|:::||:.|:|||:.|..:..|....:.||||:|.:|.|.||.:.|.:|::|
Frog   326 AMAKALESQGKILESVEYLENFIKIAKLNNLNQSLAETYSCLGDIFNTRGNYEKACQYFSKAYET 390

Human   410 TVELMSMPLMDETKVHYGIAKAHQMMLTVNNYIESADLTSLNYLLSWKESRGNIEPDPVTEEFRG 474
            .:.|..:.|::|.:|.|||||||:|||||:...:|||..|:.:||:||.:|.:|..||...:...
Frog   391 ALSLSELALIEEAQVQYGIAKAHEMMLTVSKLTDSADCASVGHLLTWKMNRSDIFGDPAKPDKLI 455

Human   475 STVEAVSQNSERLEELSRFPGDQKNET 501
            |..:  :::.::...:...|...:|||
Frog   456 SMQD--TKDGDKSIAIMETPDIPENET 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TTC29	NP_001287690.1	TPR repeat	208..252	CDD:276809	31/43 (72%)
		TPR_12	257..329	CDD:290160	41/71 (58%)
		TPR repeat	259..289	CDD:276809	20/29 (69%)
		TPR repeat	300..328	CDD:276809	14/27 (52%)
		TPR repeat	333..369	CDD:276809	17/35 (49%)
		TPR_12	336..408	CDD:290160	31/71 (44%)
		TPR repeat	380..408	CDD:276809	11/27 (41%)
ttc29	XP_002938976.1	TPR repeat	189..217	CDD:276809	18/27 (67%)
		TPR repeat	233..270	CDD:276809	25/36 (69%)
		PEP_TPR_lipo	<242..418	CDD:274350	88/175 (50%)
		TPR repeat	282..315	CDD:276809	16/32 (50%)
		TPR repeat	320..356	CDD:276809	18/35 (51%)
		TPR repeat	361..389	CDD:276809	11/27 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	292	1.000	Domainoid score	I9637
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12918
Inparanoid	1	1.050	452	1.000	Inparanoid score	I8372
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG56419
OrthoDB	1	1.010	-	-		D198774at32523
OrthoFinder	1	1.000	-	-		FOG0008970
OrthoInspector	1	1.000	-	-		oto153659
Panther	1	1.100	-	-	LDO	PTHR46630
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9221
SonicParanoid	1	1.000	-	-		X8090
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	13.110