DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AT1G22670 and RNF167

DIOPT Version :9

Sequence 1:	NP_173681.1	Gene:	AT1G22670 / 838873	AraportID:	AT1G22670	Length:	422	Species:	Arabidopsis thaliana
Sequence 2:	NP_001357232.1	Gene:	RNF167 / 26001	HGNCID:	24544	Length:	374	Species:	Homo sapiens

Alignment Length:	343	Identity:	106/343 - (30%)
Similarity:	159/343 - (46%)	Gaps:	74/343 - (21%)

- Green bases have known domain annotations that are detailed below.

plant    29 DSNITRSFVDMEADFSPSVTTVE-TGVVYVAEPLNACRNLRNKPEQSPYGTSPLVLIIRGGCSFE 92
            |.|.:..|.|:.|.|..:::... .|.:..|.|.|||..:...|.....|:..:.|:.|..|:|:
Human    31 DHNASMDFADLPALFGATLSQEGLQGFLVEAHPDNACSPIAPPPPAPVNGSVFIALLRRFDCNFD 95

plant    93 YKVRNAQRSGFKAAIVYDNVDRNFLSAMGGDSDGIK----IQAVFVMKRAGEMLKK-YAGSEEME 152
            .||.|||::|:.||:|: ||:.|.|..|..:|:.|:    |.:||:.:|:.|.|:. :...:...
Human    96 LKVLNAQKAGYGAAVVH-NVNSNELLNMVWNSEEIQQQIWIPSVFIGERSSEYLRALFVYEKGAR 159

plant   153 VMLVPPNTEDSVWSL--YASIALILSLAIFCVMVTCVFFYRYCSTIRNSTSQFNGMCRRTVKAMP 215
            |:|||.||....:.|  :..|..:|.||:..||:.....:|       ...|.|.:.:..:|.:|
Human   160 VLLVPDNTFPLGYYLIPFTGIVGLLVLAMGAVMIARCIQHR-------KRLQRNRLTKEQLKQIP 217

plant   216 SVTF----------------TCAKIDNTTGF------SCAICLEDYIVGDKLRVLPCSHKFHVAC 258
            :..:                ||  :.::|||      .|||||::|..|||||||||:|.:|..|
Human   218 THDYQKALNSSMFCPDLILPTC--LISSTGFVGDQYDVCAICLDEYEDGDKLRVLPCAHAYHSRC 280

plant   259 VDSWLISWRTFCPVCKR---------------------DARTTADEPLATESTPFLSSSIATSSL 302
            ||.||...|..||:||:                     |.....|.| |:|.||.|.|
Human   281 VDPWLTQTRKTCPICKQPVHRGPGDEDQEEETQGQEEGDEGEPRDHP-ASERTPLLGS------- 337

plant   303 VCIDSPPLGSSV-SFSPA 319
                ||.|.:|. |.:||
Human   338 ----SPTLPTSFGSLAPA 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AT1G22670	NP_173681.1	PA_C_RZF_like	17..160	CDD:239038	44/136 (32%)
		HRD1	<163..>314	CDD:227568	56/195 (29%)
		mRING-H2-C3H2C2D_ZSWM2	231..274	CDD:319400	25/42 (60%)
		modified RING-H2 finger (C3H2C2D-type)	232..273	CDD:319400	25/40 (63%)
RNF167	NP_001357232.1	PA_C_RZF_like	20..170	CDD:239038	46/139 (33%)
		RING-H2_RNF167	252..297	CDD:319711	26/44 (59%)
		RING-H2 finger (C3H2C3-type)	254..295	CDD:319711	25/40 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	71	1.000	Domainoid score	I4059
eggNOG	1	0.900	-	-		E1_KOG4628
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41046
Inparanoid	1	1.050	136	1.000	Inparanoid score	I2220
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	1	1.000	-	-		FOG0001489
OrthoInspector	1	1.000	-	-		mtm1436
orthoMCL	1	0.900	-	-		OOG6_103040
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X670
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.730