DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AT1G22670 and C18B12.4

DIOPT Version :9

Sequence 1:	NP_173681.1	Gene:	AT1G22670 / 838873	AraportID:	AT1G22670	Length:	422	Species:	Arabidopsis thaliana
Sequence 2:	NP_510498.1	Gene:	C18B12.4 / 181600	WormBaseID:	WBGene00007666	Length:	456	Species:	Caenorhabditis elegans

Alignment Length:	481	Identity:	112/481 - (23%)
Similarity:	184/481 - (38%)	Gaps:	99/481 - (20%)

- Green bases have known domain annotations that are detailed below.

plant     4 VVLLILTLLLFIV-----SYVVDA------GQVILVDSNITR--SFVDMEADFSPSVTTVETGVV 55
            ||..:..|:||.:     .||||.      |:..||...:.:  :|....:||..|...:..||
Worm     8 VVQSVGLLVLFGIYQCNAQYVVDVMRMTSFGEEELVHKCLAKGGNFGMDVSDFIISEENLGCGV- 71

plant    56 YVAEPLNACRNLRNKPEQSPYGTSPLVLIIRGG----CSFEYKVRNAQRS--GFKAAIVYDNVDR 114
             ..||::||..:|.....:....:....:.|..    |.|.::....|.|  .|:..|.|:...:
Worm    72 -GVEPVDACGPVRIAQNHTTRCHNLFAFVSRSNISHPCKFSHQAFMVQNSTYPFRLVIFYNYPGQ 135

plant   115 NFLSAMGGD-SDGIKIQAVFVMKRA-GEMLKKYAGSE--EMEVMLVPPNTEDSVWSLYASIALIL 175
            ..:|..|.: .|.:.|..:.:.... .|:.||::.:.  .:.|.:.|     ..:.|:..:...|
Worm   136 EPISMEGTELRDKVNIPVLMISHACKEEIAKKFSDTAGYRLRVRIDP-----GYYELFRYLIPFL 195

plant   176 SLAIFC----VMVTCVFFYRYCSTIRNSTSQFNGMCRRTVKAMPSVTFTCAKIDNTTGFSCAICL 236
            .:.:||    ::..||   |.|...|....:  .:.:|.:|.:|...:......:|    |||||
Worm   196 VVIVFCFALFLITLCV---RGCVERRKLNKR--RLSKRNLKKIPVKKYRLGDDPDT----CAICL 251

plant   237 EDYIVGDKLRVLPCSHKFHVACVDSWLISWRTFCPVCKRDARTTADEPLATESTPFLSSSIATSS 301
            |.:..|:|||.|||.|.||..|:|.||...|..||:|||...|.:|            |..:|:.
Worm   252 ESFASGEKLRHLPCRHVFHCNCIDVWLTQTRKICPLCKRKIGTDSD------------SECSTND 304

plant   302 LVCIDSPPLGSSVSFSPAHVSSSF-------------------------IHQFVRSS----PMNG 337
            |......|..::..::.|...|.|                         :|...|.|    ..|.
Worm   305 LASTSQGPNDATALYNNADNQSGFELPVPQGQMVDLWSSQEALVDQDIVLHNTTRRSITGFVRNA 369

plant   338 SRISENLRRQA-----SPLQSSS---QRSHLSMKSSHSLGYSTMSPLNAMGMSPYRPYPSNASPG 394
            .|...|..|..     |.|:..|   ::...|..:.|.|......|.::..::    .||:....
Worm   370 FRKLRNSPRHRDVDVHSGLEGGSYLVRQQTTSNDNDHLLENEVSDPTSSSELN----IPSSEELT 430

plant   395 LFSS-TNHLLSNYTANTFSHFASAHS 419
            :.:| :.|.|.  ||.|.:..:.:||
Worm   431 VPTSISTHSLD--TATTTTPSSPSHS 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AT1G22670	NP_173681.1	PA_C_RZF_like	17..160	CDD:239038	35/160 (22%)
		HRD1	<163..>314	CDD:227568	45/154 (29%)
		mRING-H2-C3H2C2D_ZSWM2	231..274	CDD:319400	23/42 (55%)
		modified RING-H2 finger (C3H2C2D-type)	232..273	CDD:319400	23/40 (58%)
C18B12.4	NP_510498.1	PA	<74..176	CDD:333703	20/101 (20%)
		HRD1	<223..>335	CDD:227568	39/129 (30%)
		RING-H2_RNF103	246..291	CDD:319387	26/48 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	69	1.000	Domainoid score	I2961
eggNOG	1	0.900	-	-		E1_KOG4628
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H41046
Inparanoid	1	1.050	81	1.000	Inparanoid score	I2122
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001489
OrthoInspector	1	1.000	-	-		otm278
orthoMCL	1	0.900	-	-		OOG6_103040
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X670
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.720