DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rps6kb1 and S6k

DIOPT Version :9

Sequence 1:	NP_114191.1	Gene:	Rps6kb1 / 83840	RGDID:	620683	Length:	525	Species:	Rattus norvegicus
Sequence 2:	NP_001261450.1	Gene:	S6k / 38654	FlyBaseID:	FBgn0283472	Length:	490	Species:	Drosophila melanogaster

Alignment Length:	522	Identity:	294/522 - (56%)
Similarity:	357/522 - (68%)	Gaps:	75/522 - (14%)

- Green bases have known domain annotations that are detailed below.

  Rat    20 EAEDMAGVFDIDLDQPE--DAGSEDELEEGGQLNESMDHGGVGPYELGMEHC----------EKF 72
            :..|.:.:||::|...|  |..:.|..::..:|::         .:|..|.|          |..
  Fly     3 DVSDPSELFDLELHDLELQDDKARDSDDDRIELDD---------VDLEPELCINLHQDTEGQETI 58

  Rat    73 EISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDT 137
            ::.|.:||.|..|:.|:.|||.:|||||||||||||||..|.:..|.|||||||||.||.|.|||
  Fly    59 QLCEENVNPGKIKLGPKDFELKKVLGKGGYGKVFQVRKTAGRDANKYFAMKVLKKASIVTNQKDT 123

  Rat   138 AHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEI 202
            |||:|||||||.|||||||:|:|||||.|||||||||||||||||.|||||||:|||.||||:||
  Fly   124 AHTRAERNILEAVKHPFIVELVYAFQTDGKLYLILEYLSGGELFMHLEREGIFLEDTTCFYLSEI 188

  Rat   203 SMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMR 267
            .:||||||:.||||||||||||:|:.||||||||||||||.|.:|.|||||||||||||||||.|
  Fly   189 ILALGHLHKLGIIYRDLKPENILLDAQGHVKLTDFGLCKEHIQEGIVTHTFCGTIEYMAPEILTR 253

  Rat   268 SGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNA 332
            |||.:|||||||||||:|||||.||||.|||||||:.|||.|||||.|||.|||||:::|:||..
  Fly   254 SGHGKAVDWWSLGALMFDMLTGVPPFTAENRKKTIETILKAKLNLPAYLTPEARDLVRRLMKRQE 318

  Rat   333 ASRLGAGPGDAGEVQAHPFFRHINWEELLARKVERPFKPLLQSEEDVSQFDSKFTRQTPVDSPDD 397
            ..|||:||.||..||.||||:|:||:::|||::|.|.||||:||:||||||::||||.|||||||
  Fly   319 PQRLGSGPEDAAAVQIHPFFKHVNWDDVLARRLEPPIKPLLRSEDDVSQFDTRFTRQIPVDSPDD 383

  Rat   398 STLSESANQVFLGFTYVAPSVLESVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGAS 462
            :|||||||.:|.||||||||:||.:..  :.....|||||   :||
  Fly   384 TTLSESANLIFQGFTYVAPSILEDMHR--ANRMPARSPRR---TPR------------------- 424

  Rat   463 ASTANPQTP-----VEYPMETSGIEQMDVTTSGEASAPLPI--RQPNSGPYKKQAFPMISKRPEH 520
                  |.|     :::|....|           |:|||.:  ....||.:.: |.|     |.|
  Fly   425 ------QLPDSSFRLQFPSANVG-----------ANAPLAMHGHSQRSGMFAR-ATP-----PHH 466

  Rat   521 LR 522
            ::
  Fly   467 MQ 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rps6kb1	NP_114191.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..54		7/27 (26%)
		TOS motif	28..32		2/3 (67%)
		S_TKc	91..352	CDD:214567	204/260 (78%)
		STKc_p70S6K	94..416	CDD:270736	247/321 (77%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	380..399		15/18 (83%)
		Autoinhibitory domain	424..525		21/106 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	486..509		6/24 (25%)
S6k	NP_001261450.1	PTZ00263	76..397	CDD:140289	245/320 (77%)
S6k	NP_001261450.1	STKc_p70S6K	81..402	CDD:270736	247/320 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334262
Domainoid	1	1.000	427	1.000	Domainoid score	I584
eggNOG	1	0.900	-	-		E1_KOG0598
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H81703
Inparanoid	1	1.050	554	1.000	Inparanoid score	I1078
OMA	1	1.010	-	-		QHG51952
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	1	1.000	-	-		FOG0001793
OrthoInspector	1	1.000	-	-		otm46215
orthoMCL	1	0.900	-	-		OOG6_100157
Panther	1	1.100	-	-	LDO	PTHR24351
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1494
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770