DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tnk1 and Ack

DIOPT Version :10

Sequence 1:NP_114086.3 Gene:Tnk1 / 83813 MGIID:1930958 Length:666 Species:Mus musculus
Sequence 2:NP_647859.1 Gene:Ack / 38489 FlyBaseID:FBgn0028484 Length:1073 Species:Drosophila melanogaster


Alignment Length:646 Identity:228/646 - (35%)
Similarity:317/646 - (49%) Gaps:87/646 - (13%)


- Green bases have known domain annotations that are detailed below.


Mouse     5 ASSLWLLRLLRDVQLAQFYRPILEELNVTRPEHFDFVRPEDLDNIGMGRPAQRRLNEALKRYRSG 69
            :.:.||..|||:|||.||...|.::|.|||..|||:|.|:||:..|:|:||.|||.||:::.::.
  Fly    13 SETAWLEDLLREVQLEQFLDRIRDDLQVTRLAHFDYVLPDDLERCGLGKPAIRRLMEAVRKKKAH 77

Mouse    70 VKSKNWVYKILGGFAPEQKEIPPRSDSPLCFHEPEGG---LKCLIPEGAVRRGELLGSGCFGVVH 131
            ...||.:.|::||    .|:...:..|.......:|.   |.|||.|..:..|..||.|.||||.
  Fly    78 QWRKNILSKLIGG----GKQPSSKKQSSAARESSQGNGTQLTCLIHEKDITMGLKLGDGSFGVVR 138

Mouse   132 RGLWTL-PSGQSIPVAVKSLRVGPEGPMGTELGDFLREVSVMMKLEHPHVLRLHGLVLGQPLQMV 195
            ||.|:. |:|:.||||||.|:.......|. :.||.|||..|..|:|.:::||:|:||.||:.|:
  Fly   139 RGEWSASPAGKVIPVAVKVLKSDNLTQPGI-IDDFFREVQAMHALDHANLVRLYGVVLSQPMMMI 202

Mouse   196 MELAPLGSL---------HARLTAPAPTPPLPVALLCLFLRQLAGAMAYLGSCGLVHRDLATRNL 251
            .|||..|||         |..||           ::..:..|:...||||.....:|||||.||:
  Fly   203 TELAERGSLLDTLRKQCRHTSLT-----------IIWNWSVQIVTGMAYLEQKRFLHRDLACRNV 256

Mouse   252 LLASPRMIKVADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESLRQGAFSSASDVWMFGVTLWEM 316
            |||:...||:.||||:|.|......|||...:.:|:.||||||||...||.|||.||||||||||
  Fly   257 LLAAGNKIKIGDFGLMRALPQEDDCYVMSEHKKVPFPWCAPESLRFRQFSHASDTWMFGVTLWEM 321

Mouse   317 FSGGEEPWAGVPPYLILQRLEKDRARLPKPPLCSRALYSLALRCWAPHPADRPSFSNLEGLLQEA 381
            ||.||:||.|:....||::::::..||.:|..|...:|::.|:||...||:||:|:.|:..|...
  Fly   322 FSFGEDPWVGLNGSQILRKIDREGERLHQPDACPPDVYAMMLQCWDKTPAERPTFAALKEYLASM 386

Mouse   382 WLSEGRCVREVTEPGALRMEPGDPITIIEGSLDTATWKGQNGRTLKVGNFPASAVTLADLG--GS 444
            .....|..|...|...|::||||.|.||:|..:....||||.||..:|.||.:.:....:|  |.
  Fly   387 SPPVMRASRSHHESKGLQIEPGDTIAIIDGRHELKLIKGQNQRTFDIGIFPRNLLEQRKVGAAGD 451

Mouse   445 PVTHPAHRGSPAHGEK------CRGGT-------DGDREKATLQDLPPARSHRTKMPLQRMRGIS 496
            .|.    |.|..:|..      |.||.       |..|:.|::.:.|.|:        :|....|
  Fly   452 VVM----RSSVGNGSSSSPFGFCWGGAAAMANGDDRQRKCASMTNQPHAK--------ERKSTSS 504

Mouse   497 KSLESVLSLGPRPTGGGSSPPELRRTRAM--------PQRLPDLPPRPPDLPPRPPIICNSSQPT 553
            |.......:....||       |:|..|:        |||     |.||.......:|..|..  
  Fly   505 KQFAYNKLVNDSATG-------LQRRNAVKHKGVVVGPQR-----PPPPQFQQEGILIDISPD-- 555

Mouse   554 QPHKARPKRESSHNHRTGAPGASKATVPSG-----GPLSDPEWQRKVVEVELSVHGVTYQE 609
                .||..|:......||..:|.....|.     .|:..|.:.......:|:|....|.|
  Fly   556 ----MRPIAEAGTGGAKGAGDSSSLQADSSFCILDAPIDVPTYAGSSGSGDLNVSPTYYNE 612

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tnk1NP_114086.3 SAM_TNK-like 16..67 CDD:188938 26/50 (52%)
Protein Kinases, catalytic domain 120..380 CDD:473864 119/269 (44%)
SH3 <395..436 CDD:473055 18/40 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 442..589 38/174 (22%)
UBA_like_SF 594..637 CDD:473871 4/16 (25%)
UBA_like_SF 624..663 CDD:473871
AckNP_647859.1 SAM_TNK-like 14..75 CDD:188938 31/60 (52%)
PTKc_Ack_like 128..385 CDD:270636 119/268 (44%)
UBA_TNK1 1031..1070 CDD:270513
Blue background indicates that the domain is not in the aligned region.

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