DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CASP5 and Drice

DIOPT Version :9

Sequence 1:	NP_001129584.1	Gene:	CASP5 / 838	HGNCID:	1506	Length:	447	Species:	Homo sapiens
Sequence 2:	NP_524551.2	Gene:	Drice / 43514	FlyBaseID:	FBgn0019972	Length:	339	Species:	Drosophila melanogaster

Alignment Length:	290	Identity:	77/290 - (26%)
Similarity:	123/290 - (42%)	Gaps:	48/290 - (16%)

- Green bases have known domain annotations that are detailed below.

Human   167 PESAESTNILKLCPREEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFD--HLPARNGAHYDI 229
            |.|:...|:.|         :....|...|  ..|...|.:|||..:..|:  .|.:|.|.:.|.
  Fly    66 PSSSYRKNVAK---------MVTDRHAAEY--NMRHKNRGMALIFNHEHFEVPTLKSRAGTNVDC 119

Human   230 VGMKRLLQGLGYTVVDEKNLTARDMESVLRA--FAARPEHKSSDSTFLVLMSHGILEGICG--TA 290
            ..:.|:|:.|.:.|...|:...:|   :||.  :||...|..||...:.::|||.:..|..  |.
  Fly   120 ENLTRVLKQLDFEVTVYKDCRYKD---ILRTIEYAASQNHSDSDCILVAILSHGEMGYIYAKDTQ 181

Human   291 HKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSEN 355
            :|        .|.|:..|...:|.||..|||:..:|||:|::        ....:.:..||:..:
  Fly   182 YK--------LDNIWSFFTANHCPSLAGKPKLFFIQACQGDR--------LDGGVTMQRSQTETD 230

Human   356 LEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFI----TELITCFQKYSCCCHLMEIFRKV 416
            .::....||....||:...|:.|...|||:.||||.|:    .||....::......|..:.::|
  Fly   231 GDSSMSYKIPVHADFLIAYSTVPGFYSWRNTTRGSWFMQSLCAELAANGKRLDILTLLTFVCQRV 295

Human   417 QKSFE-----VPQ--AKAQMPTIERATLTR 439
            ...||     .|:  .:.|:|.| ...|||
  Fly   296 AVDFESCTPDTPEMHQQKQIPCI-TTMLTR 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASP5	NP_001129584.1	DD	76..155	CDD:301326
CASP5	NP_001129584.1	CASc	196..445	CDD:214521	72/261 (28%)
Drice	NP_524551.2	CASc	86..330	CDD:214521	72/261 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10454
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910