DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CASP5 and Dcp-1

DIOPT Version :9

Sequence 1:	NP_001129584.1	Gene:	CASP5 / 838	HGNCID:	1506	Length:	447	Species:	Homo sapiens
Sequence 2:	NP_476974.1	Gene:	Dcp-1 / 37729	FlyBaseID:	FBgn0010501	Length:	323	Species:	Drosophila melanogaster

Alignment Length:	276	Identity:	72/276 - (26%)
Similarity:	119/276 - (43%)	Gaps:	36/276 - (13%)

- Green bases have known domain annotations that are detailed below.

Human   180 PREEFL-RLCKKNHDEIYPIKKREDRRRLALIICNTKFD--HLPARNGAHYDIVGMKRLLQGLGY 241
            |..:|: |:..:.:...|.:..:  .|.:|||..:..||  .|.:|.|.:.|...:|:..:.||:
  Fly    54 PANKFVARMPVERYASEYNMSHK--HRGVALIFNHEFFDIPSLKSRTGTNVDAQELKKAFENLGF 116

Human   242 TVVDEKNLTARDMESVLR--AFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTI 304
            .|...|:...||   :|:  ..||..:|..:|...:.::|||      ...:...|......|.|
  Fly   117 AVSVHKDCKLRD---ILKHVGKAAELDHTDNDCLAVAILSHG------EHGYLYAKDTQYKLDNI 172

Human   305 FQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKD 369
            :..|....|.||..|||:..:|||:|::        ....:.|....:..:.|:.:..||....|
  Fly   173 WHYFTATFCPSLAGKPKLFFIQACQGDR--------LDGGITLEKGVTETDGESSTSYKIPIHAD 229

Human   370 FIAFCSSTPHNVSWRDRTRGSIF----ITELITCFQKYSCCCHLMEIFRKVQKSFE--VP----- 423
            |:...|:.|...|||:...||.:    |.||....:||.....|..:.::|...||  ||
  Fly   230 FLFSYSTIPGYFSWRNINNGSWYMQSLIRELNANGKKYDLLTLLTFVNQRVALDFESNVPATPMM 294

Human   424 QAKAQMPTIERATLTR 439
            ..:.|:|.: .:.|||
  Fly   295 DRQKQIPCL-TSMLTR 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASP5	NP_001129584.1	DD	76..155	CDD:301326
CASP5	NP_001129584.1	CASc	196..445	CDD:214521	69/259 (27%)
Dcp-1	NP_476974.1	CASc	71..313	CDD:214521	69/259 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10454
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910