Protein Alignment KCNK16 and CG42594

DIOPT Version :10

• Sequence 1: NP_001128577.1
• Gene: KCNK16 / 83795
• HGNCID: 14464
• Length: 322
• Species: Homo sapiens
• Sequence 2: NP_001162668.2
• Gene: CG42594 / 8674091
• FlyBaseID: FBgn0260971
• Length: 1039
• Species: Drosophila melanogaster
• Alignment Length: 232
• Identity: 58/232 - (25%)
• Similarity: 86/232 - (37%)
• Gaps: 90/232 - (38%)

Human    78 VKGVNPKGNSTNPSNWDFGSSFFFAGTVVTTIGYGNLAPSTEAGQVFCVFYALLGIPLNVIFLNH 142
            |.||...|..  |..|:|..:|.::.||:|||||||:||.|..|::..:.||..||||.:::|:.
  Fly   587 VGGVAVGGGP--PHEWNFAKAFLYSLTVLTTIGYGNVAPRTTLGRIVTLAYAFFGIPLTLVYLSS 649

Human   143 LGTGL--------------------------RAHLAAIERWEDRPRRSQVLQ------------- 168
            .|:.|                          ...:|..||...|.|:.:.|:
  Fly   650 TGSILARVAREVFSKALCCCLCSNCGYCCYDEKRMAEKERRMRRKRQQEELRKQQAVMQEPYYVR 714

Human   169 --------------------------VLGLA----------------------LFLTLGTLVI-L 184
                                      |.||.                      :.|....::| :
  Fly   715 DVFHATPEKDAGAGAPPPNAGGPVGSVGGLGDIDSLSASESRGSMHGLSILAPILLCFSMMIIYI 779

Human   185 IFPPMVFSHVEGWSFSEGFYFAFITLSTIGFGDYVVG 221
            :|...|...:|.|...:|.||.|::||||||||.:.|
  Fly   780 VFGAAVLYRLEKWPILDGIYFCFMSLSTIGFGDMLPG 816

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNK16	NP_001128577.1	Ion_trans_2	87..145	CDD:462301	24/57 (42%)
		Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:P57789	108..113		4/4 (100%)
		Ion_trans_2	180..>219	CDD:462301	17/39 (44%)
		Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:P57789	212..217		4/4 (100%)
CG42594	NP_001162668.2	Ion_trans_2	<599..656	CDD:462301	25/56 (45%)
		Ion_trans_2	774..846	CDD:462301	18/43 (42%)