DRSC/TRiP Functional Genomics Resources

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Protein Alignment KCNK16 and CG42340

DIOPT Version :10

Sequence 1:NP_001128577.1 Gene:KCNK16 / 83795 HGNCID:14464 Length:322 Species:Homo sapiens
Sequence 2:NP_001368973.1 Gene:CG42340 / 7354472 FlyBaseID:FBgn0259242 Length:759 Species:Drosophila melanogaster


Alignment Length:358 Identity:79/358 - (22%)
Similarity:133/358 - (37%) Gaps:148/358 - (41%)


- Green bases have known domain annotations that are detailed below.


Human     6 LCSCWGGRVLP---------LLLAYVCYLLLGATIFQLLERQ----------------------- 38
            ||.|   :..|         :||..:.|..:|:.:|..||.:                       
  Fly    82 LCGC---QKAPKSHCISATGVLLLVLLYTAMGSIVFVTLEGELEDGGALETAVAASKPYPRTELA 143

Human    39 -AEAQSRDQFQL----EKLRFL--ENYTCLDQWAMEQFVQVIMEAWVKGVN------PKGNSTN- 89
             ||.:||...:|    |.|..|  ||:|.|    ..|.||:..:..::.|.      |.|...| 
  Fly   144 NAEIRSRTVDRLWSITEDLNILYKENWTRL----AAQEVQLFQDTLLRAVRQSKVYPPGGIQLNA 204

Human    90 PSN-WDFGSSFFFAGTVVTTIGYGNLAPSTEAGQVFCVFYALLGIPLNVIFLNHLGTGLRAHLAA 153
            |:: |.:.|:|.::.|::||||||.::|.|:.|:|..:.|||.|||:.:::|:.:|..|.|.:..
  Fly   205 PTHKWTYASAFLYSLTLITTIGYGGISPRTQWGRVAALVYALFGIPIVLLYLSAMGEALSAGMRC 269

Human   154 I---ERWEDRP----------------------RRS-----------QVLQVLGL---------- 172
            :   :|.:..|                      |::           |.|...||          
  Fly   270 LFRRQRVKGGPGGGPGGGASGGVGSGAGGSGGGRKTDKNKGQGHYGHQKLHQYGLPPSVYQQQQA 334

Human   173 ------------------------------------ALFLTLGTLVILIF---PPMVFSHVEGWS 198
                                                ::.:::...|:|.:   ..::|..::.||
  Fly   335 QQAQQAQQQQAQQAQQAQQQQVQQGKKSSGNRRGSPSVPISICVCVLLCYVSSGAILFHKLQNWS 399

Human   199 FSEGFYFAFITLSTIGFGDYVVGHPLNFITPSG 231
            ..|..||.|.:|.|||||:         :.|:|
  Fly   400 VLESLYFCFTSLGTIGFGE---------MAPNG 423

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KCNK16NP_001128577.1 Ion_trans_2 87..145 CDD:462301 23/59 (39%)
Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:P57789 108..113 4/4 (100%)
Ion_trans_2 180..>219 CDD:462301 15/41 (37%)
Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:P57789 212..217 4/4 (100%)
CG42340NP_001368973.1 Ion_trans_2 <208..264 CDD:462301 22/55 (40%)
Ion_trans_2 380..453 CDD:462301 17/53 (32%)

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