Protein Alignment KCNK16 and Shawl

DIOPT Version :10

• Sequence 1: NP_001128577.1
• Gene: KCNK16 / 83795
• HGNCID: 14464
• Length: 322
• Species: Homo sapiens
• Sequence 2: NP_001097131.2
• Gene: Shawl / 5740840
• FlyBaseID: FBgn0085395
• Length: 937
• Species: Drosophila melanogaster
• Alignment Length: 217
• Identity: 56/217 - (25%)
• Similarity: 80/217 - (36%)
• Gaps: 69/217 - (31%)

Human    89 NPSNWDFGS---SFFFAGTVVTTIGYGNLAPSTEAGQVFCVFYALLGI-----PLNVI------F 139
            ||.| .|.|   ..::|...:||:|||::||.|..|.......||.|:     |:.||      |
  Fly   438 NPDN-QFKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVSNFSMF 501

Human   140 LNHLGTGLRAHLAAIERW---EDRPRRSQ------------VLQVLGLALFLTLGTLVILIFP-- 187
            .:|  |..|:.|....|.   .::|||.:            :.|.......|..|.:|    |
  Fly   502 YSH--TQARSKLPKKRRRVLPVEQPRRKREPTAPHRGRTNAIKQTPPTGPGLVAGGVV----PVG 560

Human   188 ---PMVFSHVEGWS------FSEGFYFAFITLSTIGFGDYVVG-HP-----------LNFITPSG 231
               |.:..|..|.|      |.:.|..|.|....:. |..|:| ||           :|...|:.
  Fly   561 AGGPGLGGHAVGHSAAGAPMFKDAFGGAKIGTVNVN-GVNVIGLHPAQRTTTTMAMAMNEADPTP 624

Human   232 L------LPSQEPFQTP---HG 244
            :      :|..:|..||   ||
  Fly   625 MSALTYQVPMLQPTPTPAHSHG 646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNK16	NP_001128577.1	Ion_trans_2	87..145	CDD:462301	23/69 (33%)
		Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:P57789	108..113		3/4 (75%)
		Ion_trans_2	180..>219	CDD:462301	11/49 (22%)
		Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:P57789	212..217		0/4 (0%)
Shawl	NP_001097131.2	BTB_Shaw-like	4..115	CDD:349723
		Ion_trans	307..506	CDD:459842	23/70 (33%)