Protein Alignment KCNK16 and CG10864

DIOPT Version :10

• Sequence 1: NP_001128577.1
• Gene: KCNK16 / 83795
• HGNCID: 14464
• Length: 322
• Species: Homo sapiens
• Sequence 2: NP_650726.1
• Gene: CG10864 / 42222
• FlyBaseID: FBgn0038621
• Length: 389
• Species: Drosophila melanogaster
• Alignment Length: 246
• Identity: 66/246 - (26%)
• Similarity: 101/246 - (41%)
• Gaps: 58/246 - (23%)

Human    22 VCYLLLGATIFQLLERQAEAQS-------RDQFQLEKLRFLENYTCLD--QWA----------ME 67
            |.|.:.||..|..:|||...::       |.....:.....|.:..:|  :|.          ..
  Fly    58 VIYAICGAFAFMHIERQFVDETAGHVMELRQNCSQQLWSITEQHNIIDRRRWTEATNDVLREYQS 122

Human    68 QFVQVIMEAWVKGVNPKGNSTNPSNWDFGSSFFFAGTVVTTIGYGNLAPSTEAGQVFCVFYALLG 132
            |...|:...:| |.:|:      ..|.|.::..|..:|:|.|||||:.|.|..|:.|.|.||..|
  Fly   123 QIAGVVKHGYV-GRSPE------QIWSFPAALMFCLSVITMIGYGNMVPRTPWGKGFTVIYATFG 180

Human   133 IPLNVIFLNHLGTGLRAHLAAIER-----WEDRPR--------------RSQVL----QVLGLAL 174
            |||.:::..::|..|......:.|     .::.||              |.:|:    ..|.:..
  Fly   181 IPLYILYFLNMGRVLARSFKFLYRSLHDCTQEHPRLDRMDALEGGVGMTRKKVIVPSTACLWVIF 245

Human   175 FLTL-GTLVILIFPPMVFSHVEGWSFSEGFYFAFITLSTIGFGDYVVGHPL 224
            |..| ||        ::|::.|.||....|||...:|..|||||:|.|..|
  Fly   246 FYVLTGT--------VMFANWEKWSLLNSFYFCMTSLCKIGFGDFVPGASL 288

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNK16	NP_001128577.1	Ion_trans_2	87..145	CDD:462301	21/57 (37%)
		Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:P57789	108..113		3/4 (75%)
		Ion_trans_2	180..>219	CDD:462301	14/38 (37%)
		Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:P57789	212..217		3/4 (75%)
CG10864	NP_650726.1	Ion_trans_2	<141..197	CDD:462301	23/55 (42%)
		Ion_trans_2	242..>284	CDD:462301	17/49 (35%)