Protein Alignment KCNK16 and Task6

DIOPT Version :10

• Sequence 1: NP_001128577.1
• Gene: KCNK16 / 83795
• HGNCID: 14464
• Length: 322
• Species: Homo sapiens
• Sequence 2: NP_650300.2
• Gene: Task6 / 41671
• FlyBaseID: FBgn0038165
• Length: 408
• Species: Drosophila melanogaster
• Alignment Length: 211
• Identity: 71/211 - (33%)
• Similarity: 110/211 - (52%)
• Gaps: 15/211 - (7%)

Human    13 RVLPLLLAYVCYLLLGATIFQLLERQAEAQSRDQFQLEKLRFLENYTCLDQWAMEQFVQVIMEAW 77
            |.:.|::....|||:||.:|..||.:.|.:..:..|..:...:..|..    :.|.|  .:||..
  Fly     7 RTISLIVCTFTYLLVGAAVFDALESETEKRRWEALQDAEDMIIRKYNI----SQEDF--KVMETV 65

Human    78 V-KGVNPKGNSTNPSNWDFGSSFFFAGTVVTTIGYGNLAPSTEAGQVFCVFYALLGIPLNVIFLN 141
            | |..:.|..    ..|.|..:|::|.||:||||||:..|||..|::|.:.||::||||.::...
  Fly    66 VLKSESHKAG----QQWKFTGAFYYATTVLTTIGYGHSTPSTVGGKLFTMCYAIVGIPLGLVMFQ 126

Human   142 HLG---TGLRAHLAAIERWEDRPRRSQVLQVLGLALFLTLGTLVILIFPPMVFSHVEGWSFSEGF 203
            .:|   ..|.:::....|...|.:|:...:|..:.:..||.:|.| ......||..||||:.:..
  Fly   127 SIGERVNRLSSYVIKAVRSSLRCKRTVASEVDLICVVTTLSSLTI-AGGAAAFSKFEGWSYFDSV 190

Human   204 YFAFITLSTIGFGDYV 219
            |:.||||:||||||.|
  Fly   191 YYCFITLTTIGFGDMV 206

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNK16	NP_001128577.1	Ion_trans_2	87..145	CDD:462301	24/60 (40%)
		Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:P57789	108..113		4/4 (100%)
		Ion_trans_2	180..>219	CDD:462301	19/38 (50%)
		Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:P57789	212..217		4/4 (100%)
Task6	NP_650300.2	Ion_trans_2	<78..132	CDD:462301	24/53 (45%)
		Ion_trans_2	165..243	CDD:462301	22/43 (51%)