Protein Alignment KCNK16 and Shal

DIOPT Version :10

• Sequence 1: NP_001128577.1
• Gene: KCNK16 / 83795
• HGNCID: 14464
• Length: 322
• Species: Homo sapiens
• Sequence 2: NP_001097646.1
• Gene: Shal / 40129
• FlyBaseID: FBgn0005564
• Length: 571
• Species: Drosophila melanogaster
• Alignment Length: 273
• Identity: 56/273 - (20%)
• Similarity: 101/273 - (36%)
• Gaps: 86/273 - (31%)

Human    14 VLPLLLAYVCYLLLGATIFQLLERQAEAQSRDQFQLEKL---RFLENYTCLDQWAMEQFVQVIME 75
            ::|.::...||              .:.:.|.:...|:|   :..||.   || .::|...:..:
  Fly   124 IMPDVIGDCCY--------------EDYRDRKRENAERLMDDKLSENG---DQ-NLQQLTNMRQK 170

Human    76 AWVKGVNPKGNSTNPSNWDFGSSFFFAGTVVTTI----------GYGNLAPSTEAGQV--FC--- 125
            .|....||. .||:...:.:.:.||.|.:|:..:          |.....|..|..::  ||
  Fly   171 MWRAFENPH-TSTSALVFYYVTGFFIAVSVMANVVETVPCGHRPGRAGTLPCGERYKIVFFCLDT 234

Human   126 ----VFYA-----LLGIPLNVIFLN--------------HLGTGL-----------RAHLAAIER 156
                :|.|     |...|....|:.              ::|.|:           ...:..:.|
  Fly   235 ACVMIFTAEYLLRLFAAPDRCKFVRSVMSIIDVVAIMPYYIGLGITDNDDVSGAFVTLRVFRVFR 299

Human   157 WEDRPRRSQVLQVLGLAL--------FLTLG-TLVILIFPPMVF---SHVEGWSFSE---GFYFA 206
            .....|.||.|::||..|        ||... .:.|:||..::|   .:|.|.:|:.   .|::.
  Fly   300 IFKFSRHSQGLRILGYTLKSCASELGFLVFSLAMAIIIFATVMFYAEKNVNGTNFTSIPAAFWYT 364

Human   207 FITLSTIGFGDYV 219
            .:|::|:|:||.|
  Fly   365 IVTMTTLGYGDMV 377

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNK16	NP_001128577.1	Ion_trans_2	87..145	CDD:462301	16/95 (17%)
		Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:P57789	108..113		1/14 (7%)
		Ion_trans_2	180..>219	CDD:462301	13/44 (30%)
		Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:P57789	212..217		2/4 (50%)
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	4/33 (12%)
		Ion_trans	188..415	CDD:459842	40/190 (21%)
		DUF3399	471..535	CDD:463381