Protein Alignment KCNK16 and Shab

DIOPT Version :10

• Sequence 1: NP_001128577.1
• Gene: KCNK16 / 83795
• HGNCID: 14464
• Length: 322
• Species: Homo sapiens
• Sequence 2: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Alignment Length: 244
• Identity: 53/244 - (21%)
• Similarity: 89/244 - (36%)
• Gaps: 93/244 - (38%)

Human    24 YLLLGATIFQLLERQAEAQSRDQFQLEKLRFLENYTCLDQWAMEQFVQVIMEAWVKGVNPKGNST 88
            :|.:|..||..|...||...:|                     .:||.:          |:
  Fly   613 FLAMGVLIFSSLAYFAEKDEKD---------------------TKFVSI----------PE---- 642

Human    89 NPSNWDFGSSFFFAGTVVTTIGYGNLAPSTEAGQVF---CVFYALLGIPLNV-IFLNHLGTGLRA 149
                     :|::||..:||:|||::.|:|..|:|.   |....:|.|.|.: |.:|:.....:.
  Fly   643 ---------TFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVLVIALPIPIIVNNFAEFYKN 698

Human   150 HL---AAIERWE--DRPRRSQVLQVLGLALFLTLGTLVILIFPPMVFSHVEGWSFSEGFYFAFIT 209
            .:   .|::|.|  ||.:|.              |::|       .|.|:   :..:.|
  Fly   699 QMRREKALKRREALDRAKRE--------------GSIV-------SFHHI---NLKDAF------ 733

Human   210 LSTIGFGDYVV--GHPLNFITPSGLLPSQEPFQTPH-GKP--ESQQIPG 253
            ..::...|.:|  |...|.:.|.|...|     ||: |:.  :.|..||
  Fly   734 AKSMDLIDVIVDTGKQTNVVHPKGKRQS-----TPNIGRQTLDVQSAPG 777

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNK16	NP_001128577.1	Ion_trans_2	87..145	CDD:462301	18/61 (30%)
		Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:P57789	108..113		3/4 (75%)
		Ion_trans_2	180..>219	CDD:462301	5/38 (13%)
		Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:P57789	212..217		0/4 (0%)
Shab	NP_001189037.1	BTB_POZ_Shab-like	306..414	CDD:349720
		Ion_trans	464..700	CDD:459842	29/130 (22%)