Protein Alignment KCNK16 and galene

DIOPT Version :10

• Sequence 1: NP_001128577.1
• Gene: KCNK16 / 83795
• HGNCID: 14464
• Length: 322
• Species: Homo sapiens
• Sequence 2: NP_612084.1
• Gene: galene / 38133
• FlyBaseID: FBgn0035192
• Length: 729
• Species: Drosophila melanogaster
• Alignment Length: 206
• Identity: 57/206 - (27%)
• Similarity: 92/206 - (44%)
• Gaps: 44/206 - (21%)

Human     2 PSAGLC---SCWGGRVLPLLLAYVCYLLL-------GATIFQLLERQAEAQSRDQFQLEKLRFLE 56
            |..|.|   .|:..:||..::::|..:||       ||.:||.|||..|.:.:...|..::...|
  Fly    19 PQRGRCVAAICFSWKVLTCIVSHVLLVLLVVSYCVGGAYLFQHLERPHELEVKRDIQNLRVNLTE 83

Human    57 NYTCLDQWAMEQFVQVIMEA-WVKGVNPK-------------------GNSTNPSNWDFGSSFFF 101
            |.     |.:.....|:.|: |:..|:..                   ......|.|.|..|.|:
  Fly    84 NI-----WLLSDDAVVLRESDWMANVSKHLANFEKQILTAIKADGWDGDEDLRKSQWTFAGSLFY 143

Human   102 AGTVVTTIGYGNLAPSTEAGQVFCVFYALLGIPLNVIFLNHLGTGL---------RAHLAAIERW 157
            :..|:||||||:::|.|:.|:|..:|||::||||.:|.|:::|..:         |.......|.
  Fly   144 SIIVITTIGYGHISPRTDWGKVTTIFYAIVGIPLMLICLSNIGDVMATSFRFLYWRICCYVCTRT 208

Human   158 EDRPRRSQVLQ 168
            ..|||.::..|
  Fly   209 AKRPRNARSRQ 219

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNK16	NP_001128577.1	Ion_trans_2	87..145	CDD:462301	25/57 (44%)
		Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:P57789	108..113		4/4 (100%)
		Ion_trans_2	180..>219	CDD:462301
		Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:P57789	212..217
galene	NP_612084.1	Ion_trans_2	115..189	CDD:462301	26/73 (36%)
		Ion_trans_2	626..706	CDD:462301