Protein Alignment KCNK16 and CG34396

DIOPT Version :10

• Sequence 1: NP_001128577.1
• Gene: KCNK16 / 83795
• HGNCID: 14464
• Length: 322
• Species: Homo sapiens
• Sequence 2: NP_611547.2
• Gene: CG34396 / 37398
• FlyBaseID: FBgn0085425
• Length: 975
• Species: Drosophila melanogaster
• Alignment Length: 303
• Identity: 66/303 - (21%)
• Similarity: 109/303 - (35%)
• Gaps: 110/303 - (36%)

Human    19 LAY-VCYLLL---GATIFQLLERQAEAQSRDQFQLEKLRFL------------ENYTCLDQWAME 67
            :|| :|..:|   |..:|:..|..||...:.:.:..|..|:            |::..|.:..:.
  Fly   527 IAYLICMAMLLGFGGLLFRYTEGAAENIYKCEVRKVKRDFIDRLWDVSHNMREEDWKSLARQKLR 591

Human    68 QFVQVIMEAWVKGVNPKGNSTNP--SNWDFGSSFFFAGTVVTTIGYGNLAPSTEAGQVFCVFYAL 130
            .|     |..:..:...|....|  .:|:|.:.|.|..||:||||||::.|.|..|:...:.||:
  Fly   592 SF-----EDELNNLAELGLRRYPGQKSWNFVNCFIFCWTVITTIGYGHITPKTGMGRSLTIVYAI 651

Human   131 LGIPLNVIFLNHLG------------------------------------TGLRAHL-------- 151
            :|||:.:|.|..||                                    ||.....
  Fly   652 IGIPMFLIVLADLGKLFTRCVKFLWVYVRRMYYTRSCRRIRKQQQIRSAMTGFNTMYDMAIRRPS 716

Human   152 -----AAIERWEDRPRRSQVLQVLG-------------------------------LALFLTLGT 180
                 :|.|..|:....::..:.:|                               |..::.||:
  Fly   717 MFFSNSAPENDEESQADAEAARSVGTSHPETPTSPYPETFEVDDEFNLPVSVASLLLITYILLGS 781

Human   181 LVILIFPPMVFSHVEGWSFSEGFYFAFITLSTIGFGDYVVGHP 223
            ...|:..|       .|:..:.||:.||::|||||||.|..:|
  Fly   782 FGFLMMEP-------SWTPLDAFYYVFISMSTIGFGDLVPSNP 817

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNK16	NP_001128577.1	Ion_trans_2	87..145	CDD:462301	25/95 (26%)
		Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:P57789	108..113		4/4 (100%)
		Ion_trans_2	180..>219	CDD:462301	14/38 (37%)
		Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:P57789	212..217		4/4 (100%)
CG34396	NP_611547.2	Caldesmon	<64..>243	CDD:460421
		Ion_trans_2	<613..670	CDD:462301	24/56 (43%)
		Ion_trans_2	771..847	CDD:462301	19/54 (35%)