Protein Alignment KCNK16 and sand

DIOPT Version :10

• Sequence 1: NP_001128577.1
• Gene: KCNK16 / 83795
• HGNCID: 14464
• Length: 322
• Species: Homo sapiens
• Sequence 2: NP_610349.1
• Gene: sand / 35777
• FlyBaseID: FBgn0033257
• Length: 395
• Species: Drosophila melanogaster
• Alignment Length: 313
• Identity: 66/313 - (21%)
• Similarity: 119/313 - (38%)
• Gaps: 121/313 - (38%)

Human    17 LLLAYVCYLLLGATIFQLLERQAEAQSRDQFQLEKL------RFL-----------------ENY 58
            ::|....|::.||.|||.:|         .|:.|:|      ||:                 ||.
  Fly    36 IILLVTFYIIGGAFIFQSIE---------IFEYERLKSEKPHRFIARNFSGECLSRIWELTAENI 91

Human    59 TCLDQWAMEQFVQVIMEAWVKGVNPKG-NSTNPSNWDFGSSFFFAGTVVTTIGYGNLAPSTEAGQ 122
            :..|..|..:.|..::..:.:.:..|. ...:...|.|..:|.::.||:|||||||:.|.:|.|:
  Fly    92 SFFDHHAYRRRVNDVLLDYQRAIVKKQLKGPDVEQWSFSGAFLYSLTVITTIGYGNITPHSECGK 156

Human   123 VFCVFYALLGIPLNVIFLNHLG---------------------------------------TGLR 148
            :..:.||::|:||.:::|:::|                                       ..|:
  Fly   157 LVTILYAIIGMPLFLLYLSNIGDVLAKSFKWIYSKVCLCRICPGVAKRRIIRERRKMRQLARALQ 221

Human   149 AH---------------------------------------------LAAIERWEDRPRRSQVLQ 168
            .|                                             .:.||| |.|....::..
  Fly   222 MHDMENARGSSSYTSTSSTTSSNSSSSEYTRSSRQSSSLVDIQYTESDSDIER-EIRGSTDEITV 285

Human   169 VLGLALFLTLGTLVILIFPPMVFSHVEGWSFSEGFYFAFITLSTIGFGDYVVG 221
            .:.:.:|:.:|   .:::..::|...|.|::.:|.||..|:||:|||||.|.|
  Fly   286 PVTVCVFVMVG---YILWGALLFGRWEDWNYLDGSYFCLISLSSIGFGDLVPG 335

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNK16	NP_001128577.1	Ion_trans_2	87..145	CDD:462301	22/96 (23%)
		Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:P57789	108..113		4/4 (100%)
		Ion_trans_2	180..>219	CDD:462301	14/38 (37%)
		Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:P57789	212..217		3/4 (75%)
sand	NP_610349.1	Ion_trans_2	<127..183	CDD:462301	22/55 (40%)
		Ion_trans_2	292..376	CDD:462301	18/47 (38%)