Protein Alignment KCNK16 and Shaw

DIOPT Version :10

• Sequence 1: NP_001128577.1
• Gene: KCNK16 / 83795
• HGNCID: 14464
• Length: 322
• Species: Homo sapiens
• Sequence 2: NP_001137782.1
• Gene: Shaw / 33599
• FlyBaseID: FBgn0003386
• Length: 619
• Species: Drosophila melanogaster
• Alignment Length: 253
• Identity: 52/253 - (20%)
• Similarity: 97/253 - (38%)
• Gaps: 69/253 - (27%)

Human    69 FVQVIMEAW------VKGVNPKGNSTNPSNWDF-GSSFFFAGTVVTTIGYGNLAPSTEAGQV--- 123
            :::.:..||      |:.:      ::|:.|:| .||......:.|...|.:|.....|..:
  Fly   248 YIECVCNAWFTFEILVRFI------SSPNKWEFIKSSVNIIDYIATLSFYIDLVLQRFASHLENA 306

Human   124 -FCVFYALLGIPLNVIFLNHLGTGLRAHLAAIERWEDRPRRSQVLQVLGLALFLTLGTLVILIFP 187
             ...|::::.| :.:..|....:||:..:...        |:...::..|..||.||   |:||.
  Fly   307 DILEFFSIIRI-MRLFKLTRHSSGLKILIQTF--------RASAKELTLLVFFLVLG---IVIFA 359

Human   188 PMVF--------SHVEGWSFSEGFYFAFITLSTIGFGD-----YV---------------VGHPL 224
            .:|:        .|.:..|...|.::|.:|::|:|:||     |:               :..|:
  Fly   360 SLVYYAERIQPNPHNDFNSIPLGLWWALVTMTTVGYGDMAPKTYIGMFVGALCALAGVLTIALPV 424

Human   225 NFITPS-----------GLLPSQEPFQTPHGKPESQQIPGSFQKVSSMNVWPLSGMHS 271
            ..|..:           ..||.:.....|..:|...::||:...||.... |.||.||
  Fly   425 PVIVSNFAMYYSHTQARAKLPKKRRRVLPVEQPRQPRLPGAPGGVSGCGT-PGSGPHS 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNK16	NP_001128577.1	Ion_trans_2	87..145	CDD:462301	12/62 (19%)
		Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:P57789	108..113		1/4 (25%)
		Ion_trans_2	180..>219	CDD:462301	13/51 (25%)
		Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:P57789	212..217		2/4 (50%)
Shaw	NP_001137782.1	BTB_Shaw-like	24..135	CDD:349723
		Ion_trans	188..439	CDD:459842	39/208 (19%)
		PRK14959	<418..>585	CDD:184923	15/65 (23%)