Protein Alignment KCNK16 and CG43155

DIOPT Version :10

• Sequence 1: NP_001128577.1
• Gene: KCNK16 / 83795
• HGNCID: 14464
• Length: 322
• Species: Homo sapiens
• Sequence 2: NP_572720.2
• Gene: CG43155 / 32092
• FlyBaseID: FBgn0262685
• Length: 411
• Species: Drosophila melanogaster
• Alignment Length: 254
• Identity: 75/254 - (29%)
• Similarity: 116/254 - (45%)
• Gaps: 50/254 - (19%)

Human     8 SCWGG-------RVLPLLLAYVCYLLLGATIFQLLERQAEAQS----RDQFQLEKLRFLENYTCL 61
            :||..       ..:.||::...|..:|..||:.|||.||.:.    :|..:..:.|||  :|.|
  Fly    52 ACWQSMKWKSALNHIGLLVSLSIYCGVGGLIFRHLERPAEVERLSHLKDIVKTHRERFL--HTIL 114

Human    62 DQWAM--------------EQFVQVIMEAWVKGVNPKGNSTNPSNWDFGSSFFFAGTVVTTIGYG 112
            :...:              |..||...|..:..|..|........|....:.||:.||:||||||
  Fly   115 NNTEVHNLDELLSFELAKYEAAVQQAAEGGLLIVADKDFPEPYERWSILQAVFFSSTVLTTIGYG 179

Human   113 NLAPSTEAGQVFCVFYALLGIPLNVIFLNHLGTGLRAHLAAI----ERWEDRPRRSQ-------- 165
            |:.|.|..|:|||:.:||:|||..:..:...|   |....|:    :....:|:.:.
  Fly   180 NIVPVTTGGRVFCICFALIGIPFTLTVIADWG---RLFATAVSVFGKHMPTKPKFTNFIGKTWFY 241

Human   166 -VLQVLGLALFLTLGTLVILIFPPMVFSHVEGWSFSEGFYFAFITLSTIGFGDYVVGHP 223
             :|.|..|.::|..|..::|::.       :.|:|.:||||.|||::||||||.|...|
  Fly   242 AILAVGFLGVYLAAGAGLLLLWE-------DDWTFFDGFYFCFITMTTIGFGDLVPKKP 293

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNK16	NP_001128577.1	Ion_trans_2	87..145	CDD:462301	23/57 (40%)
		Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:P57789	108..113		4/4 (100%)
		Ion_trans_2	180..>219	CDD:462301	16/38 (42%)
		Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:P57789	212..217		4/4 (100%)
CG43155	NP_572720.2	Ion_trans_2	143..214	CDD:462301	27/73 (37%)
		Ion_trans_2	<267..319	CDD:462301	17/27 (63%)