Protein Alignment KCNK16 and Ork1

DIOPT Version :10

• Sequence 1: NP_001128577.1
• Gene: KCNK16 / 83795
• HGNCID: 14464
• Length: 322
• Species: Homo sapiens
• Sequence 2: NP_001285097.1
• Gene: Ork1 / 32020
• FlyBaseID: FBgn0017561
• Length: 1019
• Species: Drosophila melanogaster
• Alignment Length: 226
• Identity: 77/226 - (34%)
• Similarity: 117/226 - (51%)
• Gaps: 25/226 - (11%)

Human    13 RVLPLLLAYVCYLLLGATIFQLLERQAEAQSR----------DQFQLEKLRFLENYTCLDQWAME 67
            |.:.||:.|:.||:.||.|:..:|...|..||          :::.||:|.. :|.|..|
  Fly     5 RWILLLIFYISYLMFGAAIYYHIEHGEEKISRAEQRKAQIAINEYLLEELGD-KNTTTQD----- 63

Human    68 QFVQVIMEAWVKGVN-PKGNSTNPSNWDFGSSFFFAGTVVTTIGYGNLAPSTEAGQVFCVFYALL 131
            :.:|.|.:...|.|. |......|..|.|..:||||.||.:|:||||::|:|.||::..:.|:::
  Fly    64 EILQRISDYCDKPVTLPPTYDDTPYTWTFYHAFFFAFTVCSTVGYGNISPTTFAGRMIMIAYSVI 128

Human   132 GIPLNVIFLNHLGTGLRAHLAAIERWEDRPRRS----QVLQVLGL----ALFLTLGTLVILIFPP 188
            |||:|.|....||........||.|...:.:.|    .|...|||    .:.|..|..:.|:.|.
  Fly   129 GIPVNGILFAGLGEYFGRTFEAIYRRYKKYKMSTDMHYVPPQLGLITTVVIALIPGIALFLLLPS 193

Human   189 MVFSHVEGWSFSEGFYFAFITLSTIGFGDYV 219
            .||::.|.|.:|...|::::|.:||||||||
  Fly   194 WVFTYFENWPYSISLYYSYVTTTTIGFGDYV 224

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNK16	NP_001128577.1	Ion_trans_2	87..145	CDD:462301	25/57 (44%)
		Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:P57789	108..113		3/4 (75%)
		Ion_trans_2	180..>219	CDD:462301	15/38 (39%)
		Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:P57789	212..217		4/4 (100%)
Ork1	NP_001285097.1	Ion_trans_2	83..144	CDD:462301	26/60 (43%)
		Ion_trans_2	185..266	CDD:462301	17/40 (43%)