DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MAD1L1 and Mad1

DIOPT Version :9

Sequence 1:NP_001013858.1 Gene:MAD1L1 / 8379 HGNCID:6762 Length:718 Species:Homo sapiens
Sequence 2:NP_610477.2 Gene:Mad1 / 35954 FlyBaseID:FBgn0026326 Length:730 Species:Drosophila melanogaster


Alignment Length:740 Identity:188/740 - (25%)
Similarity:348/740 - (47%) Gaps:103/740 - (13%)


- Green bases have known domain annotations that are detailed below.


Human    15 RSLNNFISQRVEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHK 79
            ||||:..|           |.:.|.:..|...|:.:|  |.|.|.:|:.:||:..|..:....||
  Fly    54 RSLNDTAS-----------SLNMPANDSMASLQNSKL--RTELIETKAIVIQLRNEIEKKSREHK 105

Human    80 RARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKR 144
            .|.:..|..::......:....:|.||...::.|::||...:.:.........|.:...|.::.:
  Fly   106 EAILLAENKSTALKDQCDITSKKNLELQDDLKALRKRELVLKNEASRATAELNQLRLKFDESTLK 170

Human   145 LR-----EKEDSLAQAGETINALKGRISELQWSVMDQEMRV-KRLESEKQELQEQLDLQHKKCQE 203
            |:     :|||    |.:....:...:||.:        |: :|.:.|.|..:.:|:    :.::
  Fly   171 LQKEKYLQKED----ARDVHLCINNELSEYR--------RIAQRADLELQSTRNELE----RLRQ 219

Human   204 ANQKIQELQAS--QEARADHEQQIKDLE------QKLSLQEQDAA----IVKNMKSELVRLPRLE 256
            .|:::| .:||  ::.||:||:|.:.|:      |:|..:.|..:    :||..:..|..:|.|.
  Fly   220 LNEELQ-ARASGFEQLRANHEKQTQSLKVANDRIQELEFEIQSYSDWKEVVKTSRERLASVPDLL 283

Human   257 RELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERL- 320
            .|::.||..:.||..:.....||:|::...:.:|.|:|..:.....|:::...:..:|:.|.:: 
  Fly   284 AEVEHLRSHNKHLNTLIGDKLLLEEQVYDYKTRLEREEGARAEAASLQVKLLHMEQELKEWVKVA 348

Human   321 -DQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEE----LRQVSGQL 380
             |..:..::.:|..|...:.:|.:.::....:.::..|..:.|....:.|:.:    |:.:..  
  Fly   349 QDHCLANTLVSPMALRSRIEQLLKEDIIHVAEKTSSASDTKHLNTTIRDLEHKCAIYLKNIED-- 411

Human   381 LEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKV 445
            |....||  |:....|||::::.::||||..:.::.::|.:.|.:..|         ..||.|  
  Fly   412 LNIGLKR--HKNFKERLQRKLITVSKERDFYKQLVENFDKDTTLSNAS---------VADMTQ-- 463

Human   446 HSHSAEMEAQLSQALEE--LGGQKQRADMLEMELKMLKSQ---SSSAEQSFLFSREEADTLRLKV 505
                 :|:.::...:.|  :.|.|.....||.|::.|:.|   :..|.:.:...::|.||||:  
  Fly   464 -----DMQVRVRMEVLERTVTGYKDMCATLEREIQSLRQQELVNEPAGEGYDSVKKELDTLRM-- 521

Human   506 EELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECER 570
                 |..||...|..||.::..|.|:||::....||:|.|.||.:.|.:..:....:||||.||
  Fly   522 -----ENDRLRRRKEELEMEMMHRCLRGDFNMKDFKVVHFSENPAAEAYESTKNMMEKLQAEIER 581

Human   571 LRGLLRAMERGGTVPADLEAAAASLPSS-------KEVAELKKQVESAELKNQRLKEVFQTKIQE 628
            |:      .|...:..|.|.......|:       ||..:|:.::|||..|.:::::.|:...:|
  Fly   582 LK------RRNKKLEDDNEQRLNETTSTGGMTLNFKEFNQLQAELESANGKMRKMRDCFKAAREE 640

Human   629 FRKACYTLTGYQID-ITTENQYRLTSLYAEHPGDCLIFKATSPSGSKMQLLETEFSHTVGELIEV 692
            ||..||.|.||:|| |...:.||::|::||.|.|.|.....  ..:.:.|||:.:|||....|:.
  Fly   641 FRDVCYMLLGYRIDRIGANSNYRISSMFAEGPDDYLDISLN--ESNCLALLESPYSHTFNPPIDQ 703

Human   693 HLRRQDSIPAFLSSLTLELFSRQTV 717
            .| ...:.|||.|:||||||.:.||
  Fly   704 QL-AASNFPAFFSALTLELFQKATV 727

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MAD1L1NP_001013858.1 MAD 54..716 CDD:283261 176/698 (25%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:19010891 79..82 1/2 (50%)
Important for interaction with IK. /evidence=ECO:0000269|PubMed:22351768 301..340 6/40 (15%)
Necessary for interaction with NEK2. /evidence=ECO:0000269|PubMed:14978040 380..532 39/156 (25%)
Important for interaction with IK. /evidence=ECO:0000269|PubMed:22351768 439..480 10/42 (24%)
Necessary for interaction with MAD2L1. /evidence=ECO:0000269|PubMed:19010891 540..551 6/10 (60%)
Mad1NP_610477.2 MAD 80..726 CDD:283261 176/698 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 197 1.000 Domainoid score I3109
eggNOG 1 0.900 - - E1_KOG4593
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H74500
Inparanoid 1 1.050 200 1.000 Inparanoid score I3790
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D483557at33208
OrthoFinder 1 1.000 - - FOG0004279
OrthoInspector 1 1.000 - - oto89647
orthoMCL 1 0.900 - - OOG6_103958
Panther 1 1.100 - - LDO PTHR23168
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R676
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1211.900

Return to query results.
Submit another query.