DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RBM4B and SPBC23E6.01c

DIOPT Version :9

Sequence 1:	NP_113680.1	Gene:	RBM4B / 83759	HGNCID:	28842	Length:	359	Species:	Homo sapiens
Sequence 2:	NP_596601.2	Gene:	SPBC23E6.01c / 2540551	PomBaseID:	SPBC23E6.01c	Length:	473	Species:	Schizosaccharomyces pombe

Alignment Length:	211	Identity:	45/211 - (21%)
Similarity:	84/211 - (39%)	Gaps:	64/211 - (30%)

- Green bases have known domain annotations that are detailed below.

Human     4 LFIGNLPREATEQEIRSLF-EQY-----GKVL---ECDIIKNYGFVHIEDKTAAEDAIRNLHHYK 59
            :|:|:|.....|.::.||| .:|     .|::   :.::.:.||||...|:...:.|:..:....
pombe   188 IFVGDLSPNVNEFDVYSLFASRYNSCKSAKIMTDPQTNVSRGYGFVRFTDENDQKSALAEMQGQI 252

Human    60 LHGVNINVEASKNKSK--------------------------------ASTKLHVGNISPTCTNQ 92
            .....|.|..:..|||                                |::.:.||.:|...:.:
pombe   253 CGDRPIRVGLATPKSKAHVFSPVNVVPVSMPPVGFYSAAQPVPQFADTANSTVFVGGLSKFVSEE 317

Human    93 ELRAKFEEYGPVI--------ECDIVKDYAFVHMERAEDAVEAIRG--LDNTEFQGKRMHVQLST 147
            ||:..|:.:|.::        .|..|:   ||:.:.||.|:..::|  |.|:       .::||.
pombe   318 ELKYLFQNFGEIVYVKIPPGKGCGFVQ---FVNRQSAEIAINQLQGYPLGNS-------RIRLSW 372

Human   148 SRLR---TAPGMGDQS 160
            .|.:   .||.:..||
pombe   373 GRNQNPIAAPALNYQS 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RBM4B	NP_113680.1	RRM1_RBM4	2..68	CDD:410018	16/72 (22%)
		RRM2_RBM4	78..144	CDD:410019	17/75 (23%)
		PTZ00368	<145..>181	CDD:173561	7/19 (37%)
		ZnF_C2HC	161..176	CDD:197667	45/211 (21%)
		Interaction with TNPO3. /evidence=ECO:0000250	196..359
SPBC23E6.01c	NP_596601.2	RRM	70..376	CDD:223796	41/197 (21%)
		RRM1_NGR1_NAM8_like	94..173	CDD:241055
		RRM2_NGR1_NAM8_like	185..264	CDD:241057	17/75 (23%)
		RRM3_NGR1_NAM8_like	302..373	CDD:240792	19/80 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	48	1.000	Domainoid score	I3906
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910