Protein Alignment L3MBTL2 and l3mbtl2

DIOPT Version :10

• Sequence 1: NP_113676.2
• Gene: L3MBTL2 / 83746
• HGNCID: 18594
• Length: 705
• Species: Homo sapiens
• Sequence 2: NP_956326.1
• Gene: l3mbtl2 / 568473
• ZFINID: ZDB-GENE-030131-8713
• Length: 805
• Species: Danio rerio
• Alignment Length: 674
• Identity: 370/674 - (54%)
• Similarity: 456/674 - (67%)
• Gaps: 51/674 - (7%)

Human    56 NEDREAGELPTSPLHLLSPGTPRSLDGSGSEPAVCEMCGIVGTREAFFSKTKRFCSVSCSRSYSS 120
            ::|.:.|  |..|...:..|.           ..|||||.||:.:.|||:||||||.||||||||
Zfish   147 SDDGDNG--PVKPSSWVDDGI-----------VACEMCGAVGSIDTFFSRTKRFCSASCSRSYSS 198

Human   121 NSKKASILARLQGKPPTKKAKVLHKAAWSAKIGAFLHSQGTGQLADGTPTGQDALVLGFDWGKFL 185
            ||||:||||||||:|..|.:   ||.....:. ..|..:...|..:..|..|||.:.|||||.:|
Zfish   199 NSKKSSILARLQGRPSKKSS---HKLCPKTQT-EVLRPKVIEQHQESRPFVQDATLAGFDWGSYL 259

Human   186 KDHSYKAAPVSCFKHVPLYDQWEDVMKGMKVEVLNSDAVLPSRVYWIASVIQTAGYRVLLRYEGF 250
            :.....|||||||:||||..|||||..|:||||||:...|||:|||||:|:|.|||:.|||||||
Zfish   260 EKSGLLAAPVSCFRHVPLCAQWEDVYVGLKVEVLNTHTALPSKVYWIATVVQLAGYKALLRYEGF 324

Human   251 ENDASHDFWCNLGTVDVHPIGWCAINSKILVPPRTIHAKFTDWKGYLMKRLVGSRTLPVDFHIKM 315
            |:|..||.||||||.|||||||||:|:|.||||:.:|.:  |||.|||:||||:.|:|||||:||
Zfish   325 EDDDRHDLWCNLGTADVHPIGWCAVNNKPLVPPQEVHQQ--DWKSYLMERLVGAHTIPVDFHVKM 387

Human   316 VESMKYPFRQGMRLEVVDKSQVSRTRMAVVDTVIGGRLRLLYED------GDSDDDFWCHMWSPL 374
            .:|::.|||||:|:||||:|||||||:|||||||||||||||||      |:...||||||.|||
Zfish   388 ADSLRCPFRQGVRVEVVDRSQVSRTRLAVVDTVIGGRLRLLYEDAGLGPSGEVLSDFWCHMQSPL 452

Human   375 IHPVGWSRRVGHGIKMSERRSDMAHHPTFRKIYCDAVPYLFKKVRAVYTEGGWFEEGMKLEAIDP 439
            :|.||||..|.|.||.::...:|..||.||:::.::||..|||:|.||....:|:||||:|||||
Zfish   453 VHHVGWSETVDHSIKETDTNVNMGSHPAFRRVHQNSVPDQFKKLRTVYMGATFFKEGMKIEAIDP 517

Human   440 LNLGNICVATVCKVLLDGYLMICVDGGPSTDGLDWFCYHASSHAIFPATFCQKNDIELTPPKGYE 504
            |||||||||:|.|||||||:|:.:||....||.||||||||||||.|..:|:.|||.||.|.||:
Zfish   518 LNLGNICVASVRKVLLDGYIMVGIDGVEIGDGSDWFCYHASSHAILPVGYCENNDIPLTVPPGYD 582

Human   505 AQTFNWENYLEKTKSKAAPSRLFNMDCPNHGFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIH 569
            ..||.|..|||:|.:.|||.||||.|...|||..||||||||||||||:|||||:|.|.|||.:|
Zfish   583 QATFTWPVYLEETGAVAAPQRLFNTDDVGHGFTSGMKLEAVDLMEPRLVCVATVRRCVGRLLLLH 647

Human   570 FDGWDSEYDQWVDCESPDIYPVGWCELTGYQLQPPVAAEPATPLKAKEATKKKKKQFGKKRKRIP 634
            ||||:.|:||||||:||:||||||||:||||||||:..||....:...|:||.|...||:::|.
Zfish   648 FDGWEPEFDQWVDCQSPEIYPVGWCEITGYQLQPPIGPEPPQGQEHSHASKKAKPFKGKRKRRF- 711

Human   635 PTKTRPLRQGSKKPLL-----------------EDDPQGARKISSEPVPGEIIAVRVKEEHLDVA 682
                  ||:.:|..|.                 ..|.....:|.:|| ..|:||||||.|.|:..
Zfish   712 ------LRKNAKINLKTQTNENTEMIQSQEAANTSDKPSTLQIKTEP-EEEVIAVRVKVEELETP 769

Human   683 SPDKASSPEL-PVSVENIKQETDD 705
            ....|.|.|. ..::...|:|.||
Zfish   770 ILSSAQSKESHQGALTTFKREKDD 793

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
L3MBTL2	NP_113676.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..84		5/27 (19%)
		MBT 1	179..283		71/103 (69%)
		MBT_L3MBTL2_rpt1	207..308	CDD:439111	68/100 (68%)
		MBT 2	291..391		72/105 (69%)
		MBT_L3MBTL2_rpt2	310..393	CDD:439114	59/88 (67%)
		MBT 3	397..500		64/102 (63%)
		MBT_L3MBTL2_rpt3	428..518	CDD:439117	60/89 (67%)
		MBT 4	508..604		69/95 (73%)
		MBT_dSfmbt-like_rpt4	534..604	CDD:439090	55/69 (80%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	608..665		16/73 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	680..705		5/25 (20%)
l3mbtl2	NP_956326.1	THAP	5..89	CDD:461662
		MBT_L3MBTL2_rpt1	281..380	CDD:439111	68/100 (68%)
		MBT	382..471	CDD:459242	59/88 (67%)
		MBT_L3MBTL2_rpt3	506..596	CDD:439117	60/89 (67%)
		MBT_dSfmbt-like_rpt4	612..682	CDD:439090	55/69 (80%)