Protein Alignment L3MBTL2 and Scm

DIOPT Version :10

• Sequence 1: NP_113676.2
• Gene: L3MBTL2 / 83746
• HGNCID: 18594
• Length: 705
• Species: Homo sapiens
• Sequence 2: NP_731385.1
• Gene: Scm / 41168
• FlyBaseID: FBgn0003334
• Length: 877
• Species: Drosophila melanogaster
• Alignment Length: 713
• Identity: 148/713 - (20%)
• Similarity: 210/713 - (29%)
• Gaps: 310/713 - (43%)

Human    28 GGYDSFRSYNSSVGSESSSYLEESSEAENEDREAGELPT--SPLHLLSPGTPRSLDGSGSEPAVC 90
            ||.||    ::|.||.|::....::...:....|....|  ||....||.:.:...|..::.|.|
  Fly     3 GGRDS----STSSGSNSAAPGASTNATSSASASASSTSTSASPGSTTSPASTQRQRGRPAKRATC 63

Human    91 EMCG--------IVGTREAFFSKTKRFCSVSC----SRSYSS---------------NSKKASIL 128
            ..||        ::.|:    :..|.|||.:|    .::||.               |.:..||:
  Fly    64 TWCGEGKLPLQYVLPTQ----TGKKEFCSETCIAEFRKAYSKGACTQCDNVIRDGAPNKEFCSIM 124

Human   129 ARLQGKPPTKKAKVLHKAAWSAKIGAFLHSQGTGQLADG--TPTG--QDALVLGFDWGKFLKDHS 189
            .  ..|...|.....|....::  |..|.......||.|  .|||  |......|||..:|::..
  Fly   125 C--MNKHQKKNCSTRHSGGSAS--GKGLAESERKLLASGAPAPTGPFQYESFHVFDWDAYLEETG 185

Human   190 YKAAPVSCFKHVPLYDQWEDVMKGMKVEVLNSDAVLPSRVYWIASVIQTAGYRVLLRYEGFENDA 254
            .:|||..|||..                                                 :|..
  Fly   186 SEAAPAKCFKQA-------------------------------------------------QNPP 201

Human   255 SHDFWCNLGTVDVHPIGWCAINSKILVPPRTIHAKFTDWKGYLMKRLVGSRTLPVDFHIKMVESM 319
            ::||                   ||
  Fly   202 NNDF-------------------KI---------------------------------------- 207

Human   320 KYPFRQGMRLEVVDKSQVSRTRMAVVDTVIGGRLRLLYEDGDSDDDFWCHMWSPLIHPVGWSRRV 384
                  ||:||.:|...|:.|.:|.|..|:|.||||..:..||.:|||..:.|..||.:|
  Fly   208 ------GMKLEALDPRNVTSTCIATVVGVLGSRLRLRLDGSDSQNDFWRLVDSTEIHAIG----- 261

Human   385 GHGIKMSERRSDMAHHPTFRKIYCDAVPYLFKKVRAVYTEGGWFEEGMKLEAIDPLNLGNICVAT 449
                                                                             
  Fly   262 ----------------------------------------------------------------- 261

Human   450 VCKVLLDGYLMICVDGGPSTDGLDWFCYHASSHAIFPATFCQKNDIELTPPKGYEAQTFNWENYL 514
                                                   .|:||...|.||.|:.....:|..||
  Fly   262 ---------------------------------------HCEKNGGMLQPPLGFRMNASSWPGYL 287

Human   515 EKTKSKA--APSRLFNMDCP---NHGFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWD 574
            .|..:.|  ||..:|..:.|   .:.||||.||||||...|:|||.|||..:....:.:.||||.
  Fly   288 CKILNNAMVAPEEIFQPEPPEPEENLFKVGQKLEAVDKKNPQLICCATVDAIKDDQIHVTFDGWR 352

Human   575 SEYDQWVDCESPDIYPVGWCELTGYQLQPP---------------------VAAEPATPLKAKEA 618
            ..:|.|.:..|.||:|.|||..:.:.:|||                     |.||....:.|..|
  Fly   353 GAFDYWCNYRSRDIFPAGWCARSCHPMQPPGHKSRMDSSSSKQRCPRPRYTVVAESEAMVPASPA 417

Human   619 TKKKKKQFGKKRKRIPPTKTRPLRQGSKKPLLEDDP--QGARKISSEPVPGEIIAVRVKEEHL 679
            |....          |..|..|....||.|.:...|  |...|:..:    |::|.....:.|
  Fly   418 TAHFH----------PNCKGGPFINNSKLPCMVTGPTYQTLAKLCLQ----EVLAASTDTQQL 466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
L3MBTL2	NP_113676.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..84		15/57 (26%)
		MBT 1	179..283		15/103 (15%)
		MBT_L3MBTL2_rpt1	207..308	CDD:439111	5/100 (5%)
		MBT 2	291..391		24/99 (24%)
		MBT_L3MBTL2_rpt2	310..393	CDD:439114	24/82 (29%)
		MBT 3	397..500		4/102 (4%)
		MBT_L3MBTL2_rpt3	428..518	CDD:439117	11/89 (12%)
		MBT 4	508..604		40/100 (40%)
		MBT_dSfmbt-like_rpt4	534..604	CDD:439090	31/69 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	608..665		13/58 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	680..705		148/713 (21%)
Scm	NP_731385.1	zf-FCS	58..95	CDD:428958	10/40 (25%)
		MBT_dScm_rpt1	196..294	CDD:439097	40/320 (13%)
		MBT_dScm_rpt2	312..383	CDD:439100	32/70 (46%)
		SLED	418..522	CDD:463469	13/63 (21%)
		SAM_Scm	800..870	CDD:188977