Protein Alignment L3MBTL2 and Sfmbt

DIOPT Version :10

• Sequence 1: NP_113676.2
• Gene: L3MBTL2 / 83746
• HGNCID: 18594
• Length: 705
• Species: Homo sapiens
• Sequence 2: NP_001137821.1
• Gene: Sfmbt / 34709
• FlyBaseID: FBgn0032475
• Length: 1243
• Species: Drosophila melanogaster
• Alignment Length: 878
• Identity: 298/878 - (33%)
• Similarity: 416/878 - (47%)
• Gaps: 225/878 - (25%)

Human     9 ETPSSEPMEEEEDDDLELFGGYDSFRSYNSSVGSESSSYL----EESSEAENEDREAGELPTSPL 69
            |..||:.|:                |:|:::.|:.|::..    ..:|.|....|:..::  .|:
  Fly   253 ENTSSKQMQ----------------RTYSTAKGANSTATTATCSASTSSALRSQRKTRKI--EPV 299

Human    70 HLLSPG----TPRSLDGSGSEP----------AVCEMCGIVGTREAFFSKTKRFCSVSCSRS--Y 118
            :  .||    ||.:..|: .:|          |||:.||.:|.:..|::|::||||::|:|.  |
  Fly   300 N--RPGLVLKTPIAYRGN-IDPSVIPIQKDGMAVCKRCGAIGVKHTFYTKSRRFCSMACARGELY 361

Human   119 S--SNSKKASILARLQGKPP--------------------------------------TKKAKVL 143
            |  .|:|.....|......|                                      |.::|:.
  Fly   362 SLVLNTKMEGDQATTSSPDPGAGSESADLPGDQQQSQSDIELDLHAAHIKNANYRFRITDQSKIT 426

Human   144 H-------------KAAWSAKIGA--FLHSQGTGQLADGTPTG---------------------- 171
            .             .||.:.::.|  .:.:...|.:.|.|..|
  Fly   427 QLNSFGEPMSMGGDAAANNVQMAADETIAALNGGAVGDATAPGSTEEGASTPNSYLSAAPTPKAL 491

Human   172 --------QDAL-----------------------------VLGFDWGKFLKDHSYKAAPVSCFK 199
                    ||.|                             ...:||...|...::.||||:||.
  Fly   492 RLFKDIYPQDDLPQIPKYERLPVPCPQMEKIISIRRRMYDPTHSYDWLPRLSKENFNAAPVTCFP 556

Human   200 HVPLYDQWEDVMKGMKVEVLNSD-----AVLPSRV---YWIASVIQTAGYRVLLRYEGFENDASH 256
            |.|..:.|:::..||||||.|:|     .:.|.:.   :|:|::::..||:.|:.||||:.| ||
  Fly   557 HAPGCEVWDNLGVGMKVEVENTDCDSIEVIQPGQTPTSFWVATILEIKGYKALMSYEGFDTD-SH 620

Human   257 DFWCNLGTVDVHPIGWCAINSKILVPPRTIHAKFTDWKGYLMKRLVGSRTLPVDFHIKMVESMKY 321
            |||.||...:||.:||||...|.|:|||||..|:.|||.:|:.||.|:||||.:|:.|:.:|::.
  Fly   621 DFWVNLCNAEVHSVGWCATRGKPLIPPRTIEHKYKDWKDFLVGRLSGARTLPSNFYNKINDSLQS 685

Human   322 PFRQGMRLEVVDKSQVSRTRMAVVDTVIGGRLRLLYEDGDSDDDFWCHMWSPLIHPVGWSRRVGH 386
            .||.|:.||.|||.::|:.|:|.|..::|.||.|.|  .||||.||||..||:||||||:..|||
  Fly   686 RFRLGLNLECVDKDRISQVRLATVTKIVGKRLFLRY--FDSDDGFWCHEDSPIIHPVGWATTVGH 748

Human   387 GI--------KMSERRSDM--AHHPTFRKIYCDAVPYLFK---KVRAVYTEG--GWFEEGMKLEA 436
            .:        :|...|..|  .|..       ||...|||   .....|::|  ..|.|||||||
  Fly   749 NLAAPQDYLERMLAGREAMIEVHED-------DATIELFKMNFTFDEYYSDGKTNSFVEGMKLEA 806

Human   437 IDPLNLGNICVATVCKVLLDGYLMICVDG-GPSTDGLDWFCYHASSHAIFPATFCQKNDIELTPP 500
            :|||||.:||.|||..||..||:||.:|. .|...|.||||||..|..||||.||..|:|.:|||
  Fly   807 VDPLNLSSICPATVMAVLKFGYMMIRIDSYQPDASGSDWFCYHEKSPCIFPAGFCSVNNISVTPP 871

Human   501 KGYEAQTFNWENYLEKTKSKAAPSRLFNMDCPNHGFKVGMKLEAVDLMEPRLICVATVKRVVHRL 565
            .||:::||.||.||..|.:.||...||:...|:|||:|||.||..|||:|||:|||||.|||.||
  Fly   872 NGYDSRTFTWEGYLRDTGAVAAGQHLFHRIIPDHGFEVGMSLECADLMDPRLVCVATVARVVGRL 936

Human   566 LSIHFDGWDSEYDQWVDCESPDIYPVGWCELTGYQLQPP------VAAEPATPLKAKEATKKKKK 624
            |.:|||||..|||||:||||.||||||||.|..::|:.|      .|.:||...|.:...|.||.
  Fly   937 LKVHFDGWTDEYDQWLDCESADIYPVGWCVLVNHKLEGPPRVAHQQAPKPAPKPKIQRKRKPKKG 1001

Human   625 QFGKKRKRIPPTKTRPLRQGSKKPLLEDDPQGARKISSEPVPGEIIAVRVKEEHLDVA-----SP 684
            ..|.|    .||........|:...|:..|.         :|...|.:.:|.||.:.|     .|
  Fly  1002 AAGGK----TPTDNNTQSVKSRTIALKTTPH---------LPKLSIKLELKPEHHNAAFYENNQP 1053

Human   685 DKASSPELP------------VSVENIKQETDD 705
            ::....|.|            :|.::..|.:.|
  Fly  1054 EEEGDEEDPDADGDGDGSTSHISEQSTTQSSSD 1086

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
L3MBTL2	NP_113676.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..84		17/82 (21%)
		MBT 1	179..283		46/111 (41%)
		MBT_L3MBTL2_rpt1	207..308	CDD:439111	50/108 (46%)
		MBT 2	291..391		50/107 (47%)
		MBT_L3MBTL2_rpt2	310..393	CDD:439114	40/90 (44%)
		MBT 3	397..500		52/110 (47%)
		MBT_L3MBTL2_rpt3	428..518	CDD:439117	53/90 (59%)
		MBT 4	508..604		60/95 (63%)
		MBT_dSfmbt-like_rpt4	534..604	CDD:439090	49/69 (71%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	608..665		13/56 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	680..705		6/41 (15%)
Sfmbt	NP_001137821.1	MBT_dSfmbt_rpt1	564..672	CDD:439109	50/108 (46%)
		MBT_dSfmbt_rpt2	674..753	CDD:439112	39/80 (49%)
		MBT_dSfmbt_rpt3	798..904	CDD:439115	58/105 (55%)
		MBT_dSfmbt_rpt4	905..976	CDD:439118	49/70 (70%)
		SAM_Scm-like-4MBT	1160..1226	CDD:188979