Protein Alignment SLC25A18 and Shawn

DIOPT Version :10

• Sequence 1: NP_113669.1
• Gene: SLC25A18 / 83733
• HGNCID: 10988
• Length: 315
• Species: Homo sapiens
• Sequence 2: NP_001027071.1
• Gene: Shawn / 3772641
• FlyBaseID: FBgn0031039
• Length: 387
• Species: Drosophila melanogaster
• Alignment Length: 343
• Identity: 80/343 - (23%)
• Similarity: 131/343 - (38%)
• Gaps: 99/343 - (28%)

Human    23 VTCVF--PIDLAKTRLQNQHGKAM---------------------------------YKGMIDCL 52
            ||..|  |:|:.|||||.|....:                                 :.|.||..
  Fly    52 VTACFMTPLDVIKTRLQAQQQALLSNKCFLYCNGLMDHICPCGPDTPNPAAAKPAPRFSGTIDAF 116

Human    53 MKTARAEGFFGMYRGAAVNLTLVTPEKAIKLAANDFFRRLLME---------DGMQRNLK----- 103
            :|.:|.||...::.|.:..|....|...|...|.:.|:....:         |.:..::.
  Fly   117 IKISRTEGIGSLWSGLSPTLISALPSTIIYFVAYEQFKARFTDIHYKYTRRPDTIAHDIPHPIPF 181

Human   104 -MEMLAGCGAGMCQVVVTCPMEMLKIQLQDAGRLAVHHQGSASAPSTSRSYTTGSASTHRRPSAT 167
             :.:|||....:..|....|:|:::.::|                        ....||.....|
  Fly   182 LVPLLAGVSGRILAVTCVSPVELIRTKMQ------------------------SQRMTHAEMFGT 222

Human   168 LIAWELLRTQGLAGLYRGLGATLLRDIPFSIIYFPLFANL-NNLGFNELAGKASFAHSFVSGCVA 231
            :  .:::::||:.||:|||..|:|||:|||.||:..:..| ::.|..|    .:|:.||.:|.::
  Fly   223 I--RQVVQSQGVLGLWRGLPPTILRDVPFSGIYWTCYEYLKSSFGVVE----PTFSFSFAAGAIS 281

Human   232 GSIAAVAVTPLDVLKTRIQTLKKGLGEDMYSGITDCARKLWIQEGP--SAFMKGAGCRALVIAPL 294
            ||:||...||.||:||..|              .:...|....:.|  ....|....|...|..:
  Fly   282 GSVAATITTPFDVVKTHEQ--------------IEFGEKFIFSDNPPKQVATKSVAMRLASIYRM 332

Human   295 FGIAQGVYFIGIGERILK 312
            .|:.  ..|.|:|.|:.|
  Fly   333 GGVP--AIFSGLGPRLFK 348

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC25A18	NP_113669.1	Mito_carr	4..97	CDD:395101	24/117 (21%)
		Solcar 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	6..92		24/103 (23%)
		Solcar 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	100..210		27/116 (23%)
		Mito_carr	106..204	CDD:395101	26/97 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	141..160		0/18 (0%)
		Mito_carr	217..302	CDD:395101	21/86 (24%)
		Solcar 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	219..308		23/90 (26%)
Shawn	NP_001027071.1	Mito_carr	39..159	CDD:395101	24/106 (23%)
		Mito_carr	178..265	CDD:395101	27/112 (24%)
		Mito_carr	268..371	CDD:395101	27/101 (27%)