Protein Alignment ESPN and espn

DIOPT Version :10

• Sequence 1: XP_011540533.1
• Gene: ESPN / 83715
• HGNCID: 13281
• Length: 1341
• Species: Homo sapiens
• Sequence 2: XP_073765811.1
• Gene: espn / 567061
• ZFINID: ZDB-GENE-081105-173
• Length: 895
• Species: Danio rerio
• Alignment Length: 898
• Identity: 484/898 - (53%)
• Similarity: 593/898 - (66%)
• Gaps: 105/898 - (11%)

Human     1 MALEQALQAARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAA 65
            |.:|:.|.|||||::..|:...|..:|...::|.|.|.|||||||||||.|||:||:||.|||.:
Zfish     1 MVVERTLLAARQGDVQTLKVQFAEKVLNGDVKDVLGATPVHHAARAGKLTCLRYLVDEAGLPANS 65

Human    66 RARNGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGD 130
            .|||||:|||||:|||:|.|||||::.||||..|||:|||||||||:||.|.|:::|||....||
Zfish    66 LARNGASPAHDAAATGNLTCLQWLVTHGGCRAADKDSSGATVLHLASRFSHHEIIDWLLKSEEGD 130

Human   131 PTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQEC 195
            ||.|||.||||:||||||||.||||||:||.|:.||.||||||||||||||||||||.||||::|
Zfish   131 PTVATDTGALPVHYAAAKGDLPSLRLLLEHSPQVVNFQTKNGATPLYLACQEGHLEVVQYLVKDC 195

Human   196 GADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLL 260
            ||:|..||:||||||||||||||:.|||||:|.|::|||::|.||||||||||||||.|||||||
Zfish   196 GAEPSIRANDGMTPLHAAAQMGHNTVIVWLMSFTEISLSDRDNDGATAMHFAASRGHAKVLSWLL 260

Human   261 LHGGEISADLWGGTPLHDAAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNGHSHCTRYLR 325
            ||||||..|.|||||||||||||||||||||||||.:|.:||:||::||||:::|||..|.:|||
Zfish   261 LHGGEIMTDSWGGTPLHDAAENGELECCQILVVNGVDLGIRDQDGFSAADLAEYNGHQQCAKYLR 325

Human   326 TVENLSVEHRVLSRDPSAELEAKQPDSGMSSPNTTV--SVQPL-NFDLSSPTSTLSNYDSCSSSH 387
            ||||:||||||||||.||:||.||||||:||||.|:  ...|. :||:.||:|:||||||.:||.
Zfish   326 TVENMSVEHRVLSRDASADLEYKQPDSGLSSPNATLPNPAPPAGHFDICSPSSSLSNYDSANSSQ 390

Human   388 SSI----KGQHP---PCGLSSARAADIQSYMDMLNPELGLPRGTIGKPTPPPPPPSFPPPPPPPG 445
            ||.    .|..|   |.|.:.:...|:|:|||||||:.........:....||||:|||||||..
Zfish   391 SSTGEKRSGSPPSRVPTGGTDSAITDMQTYMDMLNPDEACGSHNAKEAAHLPPPPTFPPPPPPSN 455

Human   446 -TQLPPPPPGYPAPKPPVGPQAADIYMQTKNKLRHVETEALKKE-LSSCDGHDGLRRQDSSRKPR 508
             :.:|||||.||||.||...:.:..|::.|..||.|:.:.:||| |:..:.|:.|||.||:||.|
Zfish   456 PSHIPPPPPAYPAPNPPEEEEVSAEYLKVKRNLRRVDNDVVKKEQLNPGENHERLRRVDSNRKSR 520

Human   509 AFSKQPSTGDYYRQLGRCPGETLAARP--GMAHSEEAALL---PGNHVP---NGCAADPKASREL 565
            :|||||||||||:.||   .:|...:|  .||.:||.:.|   ..:..|   ||..    .:.:|
Zfish   521 SFSKQPSTGDYYKTLG---SDTTDQQPSRAMAPNEEGSALLEEAADTAPAPENGTG----TTEDL 578

Human   566 PPPPPPPPPPLPEAASSPPPAPPLPLE--------SAGPGCGQRRSSSSTGK------------- 609
            |.||||||||......:|||.||||.|        :..|...|||.|||:.|
Zfish   579 PLPPPPPPPPASTFIPAPPPPPPLPSELPPPPPPSTTTPAAAQRRMSSSSNKGHLSSTHLSPSVA 643

Human   610 --VRVLRHRKSTKSFNMMSPTGDNSELLAEIKAGKSLKPTPQSKGLTTVFSGIGQPA------FQ 666
              ...||.|||.|||||||||||||||||||||||||||||.|||.|||||..|.|.      ..
Zfish   644 PAPETLRQRKSNKSFNMMSPTGDNSELLAEIKAGKSLKPTPHSKGYTTVFSNSGTPGNNGESPSS 708

Human   667 PDSPLPSVSPALS-------PVRSPTPP---AAGFQP--------------LLNGSLVPVPPTTP 707
            |..|||..:...|       |...||||   |:...|              .:||:...|...|.
Zfish   709 PPEPLPKPNDTQSAKPESPPPACPPTPPNPTASRSSPQNLSTSQSSDQLTAAVNGNTSVVQNKTS 773

Human   708 APGVQLDVEALIPTHDEQGRPIPEWKRQVMVRKMQLKMQEEEEQRRKLTAASSCCYPREGWRYSR 772
            .    :|||:|:||||||||.||||||||||||:|:|||||||.:||....::.......||
Zfish   774 V----VDVESLVPTHDEQGRAIPEWKRQVMVRKLQVKMQEEEENKRKAEEEAARLASLPAWR--- 831

Human   773 EHNAILGPFGELMTEADIL--RIEQQIENLQVLHKAQKLEARLEQLELELEQL 823
                           .||:  ::|::.|..:...:.:::|...|: :.|||:|
Zfish   832 ---------------RDIMKKKLEEEKEQKRKDEEQRRMEKESEE-KSELERL 868

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ESPN	XP_011540533.1	ANKYR	2..277	CDD:440430	194/274 (71%)
		ANK repeat	39..67	CDD:293786	21/27 (78%)
		ANK repeat	69..101	CDD:293786	22/31 (71%)
		ANK repeat	103..135	CDD:293786	20/31 (65%)
		ANK repeat	137..169	CDD:293786	23/31 (74%)
		ANK repeat	171..203	CDD:293786	25/31 (81%)
		PLN03192	<196..365	CDD:215625	128/170 (75%)
		ANK repeat	239..269	CDD:293786	27/29 (93%)
		ANK repeat	271..302	CDD:293786	26/30 (87%)
		WH2	627..652	CDD:460490	23/24 (96%)
espn	XP_073765811.1	None