Protein Alignment ESPN and Espn

DIOPT Version :10

• Sequence 1: XP_011540533.1
• Gene: ESPN / 83715
• HGNCID: 13281
• Length: 1341
• Species: Homo sapiens
• Sequence 2: XP_038966608.1
• Gene: Espn / 56227
• RGDID: 620652
• Length: 887
• Species: Rattus norvegicus
• Alignment Length: 895
• Identity: 638/895 - (71%)
• Similarity: 696/895 - (77%)
• Gaps: 92/895 - (10%)

Human     1 MALEQALQAARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAA 65
            ||||||:||||:|:|||||||||||||||||||||||||||||||:|||||||:||||.||||.:
  Rat     1 MALEQAMQAARRGDLDVLRSLHAAGLLGPSLRDPLDALPVHHAARSGKLHCLRYLVEEVALPAVS 65

Human    66 RARNGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGD 130
            ||||||||||||:|||:|:||||||:|||||||:||||||||||||||||||:||||||:.||.:
  Rat    66 RARNGATPAHDAAATGYLSCLQWLLTQGGCRVQEKDNSGATVLHLAARFGHPDVVNWLLYQGGAN 130

Human   131 PTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQEC 195
            ....||.|||||||||||||.||::|||.||||||||||.||||||||||||||||||:||||||
  Rat   131 SAITTDTGALPIHYAAAKGDLPSMKLLVGHYPEGVNAQTNNGATPLYLACQEGHLEVTKYLVQEC 195

Human   196 GADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLL 260
            .||||.||.||||||||||||||:||:|||||..|||.||||.||||||||||||||||||||||
  Rat   196 SADPHLRAQDGMTPLHAAAQMGHNPVLVWLVSFADVSFSEQDHDGATAMHFAASRGHTKVLSWLL 260

Human   261 LHGGEISADLWGGTPLHDAAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNGHSHCTRYLR 325
            |||.|||.|||||||||||||||||||||||.||||.|||||.||||||||:|||||:||:||||
  Rat   261 LHGAEISQDLWGGTPLHDAAENGELECCQILAVNGAGLDVRDHDGYTAADLADFNGHTHCSRYLR 325

Human   326 TVENLSVEHRVLSRDPSAELEAKQPDSGMSSPNTTVSVQPLNFDLSSPTSTLSNYDSCSSSHSSI 390
            ||:.||:||||||||||.:||||||||||||||||:||||.||||.||||||||||||||||||.
  Rat   326 TVQTLSLEHRVLSRDPSMDLEAKQPDSGMSSPNTTMSVQPPNFDLGSPTSTLSNYDSCSSSHSSS 390

Human   391 KGQHPPCGLSSARAADIQSYMDMLNPELGLPRGTIGKPT--PPPPPPSFPPPPPPPGTQLPPPPP 453
            |||....|:..||::|:||||||||||   ||...|||:  |||||||| |||||||||||||||
  Rat   391 KGQRSTRGVPGARSSDLQSYMDMLNPE---PRSKQGKPSSLPPPPPPSF-PPPPPPGTQLPPPPP 451

Human   454 GYPAPKPPVGPQAADIYMQTKNKLRHVETEALKKELSSC----------------DGHD------ 496
            |||||.||||....:|||||||||||||.::||||..:|                ||:.
  Rat   452 GYPAPNPPVGLHLDNIYMQTKNKLRHVEVDSLKKESKACHPKVEPNDQFAQPSSGDGYSGLRRQD 516

Human   497 ----------------GLRRQDSSRKPRAFSKQPSTGDYYRQLGRCPGETLAARPGMAHSEE--- 542
                            |||||||.||.|:||||||||||||||||.|||.||||||||||||
  Rat   517 SGLLRQDSELLLRHNTGLRRQDSDRKQRSFSKQPSTGDYYRQLGRSPGEPLAARPGMAHSEEVRV 581

Human   543 ---------------------------AALLPGNHVPNGCAADPKASRELPPPPPPPPPPLPEAA 580
                                       |||||||||.|||:||.||||||  ||||||||||||.
  Rat   582 HQPAPAGCTGSNPVSHSSLSGPSAPPQAALLPGNHVHNGCSADSKASREL--PPPPPPPPLPEAL 644

Human   581 SSPPPAPPLPLESAGPGCGQRRSSSSTGKVRVLRHRKSTKSFNMMSPTGDNSELLAEIKAGKSLK 645
            ||||||||||:|.||..|||||||||||         ||||||||||||||||||||||||||||
  Rat   645 SSPPPAPPLPIEGAGAACGQRRSSSSTG---------STKSFNMMSPTGDNSELLAEIKAGKSLK 700

Human   646 PTPQSKGLTTVFSGIGQPAFQPDSPLPSVSPALSPVRSPTPPAAGFQPLLNGSLVPVPPTTPAPG 710
            ||||||||||||||.||||.||:||.|:|||..|..|||||||:|.|||||||:||.||.|.|||
  Rat   701 PTPQSKGLTTVFSGSGQPASQPESPQPAVSPGPSRARSPTPPASGPQPLLNGSIVPAPPATLAPG 765

Human   711 VQLDVEALIPTHDEQGRPIPEWKRQVMVRKMQLKMQEEEEQRRKLTAASSCCYPREGWRYSREHN 775
            |.|||||||||.||||||||||||||||||:|.|||||||||||.....:.......||     .
  Rat   766 VHLDVEALIPTLDEQGRPIPEWKRQVMVRKLQQKMQEEEEQRRKEEEEEARLASLPAWR-----R 825

Human   776 AILGPFGELMTEADILRIEQQIENLQVLHKAQKLEARLEQLELELEQLLP 825
            .||..  :|..|.:..|.|::.:.|:.:.:|::...:|..|..:..:|.|
  Rat   826 DILRK--KLEEEREQKRKEEERQKLEEIQRAKEQSEKLRTLGYDEAKLAP 873

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ESPN	XP_011540533.1	ANKYR	2..277	CDD:440430	234/274 (85%)
		ANK repeat	39..67	CDD:293786	22/27 (81%)
		ANK repeat	69..101	CDD:293786	26/31 (84%)
		ANK repeat	103..135	CDD:293786	23/31 (74%)
		ANK repeat	137..169	CDD:293786	26/31 (84%)
		ANK repeat	171..203	CDD:293786	28/31 (90%)
		PLN03192	<196..365	CDD:215625	145/168 (86%)
		ANK repeat	239..269	CDD:293786	28/29 (97%)
		ANK repeat	271..302	CDD:293786	28/30 (93%)
		WH2	627..652	CDD:460490	24/24 (100%)
Espn	XP_038966608.1	ANK repeat	39..67	CDD:293786	22/27 (81%)
		ANKYR	52..324	CDD:440430	229/271 (85%)
		ANK repeat	69..101	CDD:293786	26/31 (84%)
		ANK repeat	103..135	CDD:293786	23/31 (74%)
		ANK repeat	137..169	CDD:293786	26/31 (84%)
		ANK repeat	171..202	CDD:293786	28/30 (93%)
		ANK repeat	205..237	CDD:293786	26/31 (84%)
		ANK repeat	239..269	CDD:293786	28/29 (97%)
		ANK repeat	271..302	CDD:293786	28/30 (93%)
		WH2	682..707	CDD:460490	24/24 (100%)