Protein Alignment ESPN and f

DIOPT Version :10

• Sequence 1: XP_011540533.1
• Gene: ESPN / 83715
• HGNCID: 13281
• Length: 1341
• Species: Homo sapiens
• Sequence 2: NP_001036284.1
• Gene: f / 32718
• FlyBaseID: FBgn0262111
• Length: 1918
• Species: Drosophila melanogaster
• Alignment Length: 1497
• Identity: 300/1497 - (20%)
• Similarity: 494/1497 - (32%)
• Gaps: 412/1497 - (27%)

Human    13 GELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEA------------------ 59
            |.:..:..::..|.:..|.|....||.:|:||..|.|.|::.||..:
  Fly   349 GGMGQVGQMYHPGSVSGSERPNGGALALHYAAARGCLDCVQLLVAASVDICYFSTINVKKGLLGR 413

Human    60 ---ALPAAARARNGATPAHD--------------ASATGHLACLQWLLSQGGCRVQDKDNSGATV 107
               :|.:..|::..:...:|              .|::.|       .|..|..:.|......::
  Fly   414 MTTSLTSYRRSKQKSKSNNDIHTIIATEVVTAAILSSSVH-------SSSTGSEIGDGGQGNTSL 471

Human   108 LHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLV------------EH 160
            :..||............|....||.|.|:|...|..:...|.....:|..:            |.
  Fly   472 IEEAAAQDQSSEEQDRQHQHAKDPLAQTEMNHHPHSHHQRKSAVEVVRQQMDDDGDQDSNDDDET 536

Human   161 YP--EGV--------------NAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARAHDGMTP 209
            .|  .||              |.|..|..||:|||.|||||||.::||.|.|...:.||.|||.|
  Fly   537 MPMMSGVGRKEQNNRRSVVSANTQMDNDVTPVYLAAQEGHLEVLKFLVLEAGGSLYVRARDGMAP 601

Human   210 LHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEISADLWGGT 274
            :|||:|||....:.|:|....|..:.:|.||||.:||||||||..|:.|||.||.::|.|.:|.:
  Fly   602 IHAASQMGCLDCLKWMVQDQGVDPNLRDGDGATPLHFAASRGHLSVVRWLLNHGAKLSLDKYGKS 666

Human   275 PLHDAAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNGHSHCTRYLRTVENLSVEHRVLSR 339
            |::|||||.::||..:||.:|..:              |:||.|...|: ::.:.|..:|:
  Fly   667 PINDAAENQQVECLNVLVQHGTSV--------------DYNGKSSSQRH-KSQQQLHQQHQ---- 712

Human   340 DPSAELEAKQPDSGMSSPNTTVSVQPLNFDLSSPTSTLSNYDSCSSSHSSIKGQ----HPP--CG 398
                :.:.:|....:||...:      |.:.|..||..:...|.|||..|...:    |||  .|
  Fly   713 ----QQQQQQQQQHLSSSCNS------NSNSSKQTSRSNTIKSKSSSTLSSDVEPFYLHPPALAG 767

Human   399 LSSARAADIQSYMDMLNPELGLPRGTIGKPTPPPPPPSFPPPPPPPGTQLPPPPPGYPAPKPPVG 463
            .|......:...|.|   .:|:..|.
  Fly   768 GSGGSGMGLGMGMGM---GMGMSMGL--------------------------------------- 790

Human   464 PQAADIYMQTKNKLRHVETEALKKELSSCDGHDGLRRQDS----SRKPRAFSKQPSTGDYYRQLG 524
                                             |:.|::|    |::.|:.|::...|.  ..||
  Fly   791 ---------------------------------GISRKNSDALYSQQSRSSSEKLYNGS--SSLG 820

Human   525 RCPGETLAA---RPGMAHSEEAALLPGNHVPNGCAADPKASRELPPPPPPPPPPLPEAASSPPP- 585
            ..||...::   ..|.......||||.    :|...:|..:..:...|.|......|:.....|
  Fly   821 GNPGGNSSSGGGGVGGGGGSGGALLPN----DGLYVNPMRNGGMYNTPSPNGSISGESFFLHDPQ 881

Human   586 ------APPLPLESAGPGCGQRRSSSSTGKVRVLRHRKSTKSFNMMSPTGDNSELLAEIKAGKSL 644
                  ...|.::|   .|     |||     |.:|.||.....:.|..|:...:.|::.:..|.
  Fly   882 DIIYNRVRDLFVDS---DC-----SSS-----VKQHGKSHAHQLLQSKAGNAMTIQADVHSSSSG 933

Human   645 KPTPQSKGLTTVFSGIGQPAFQPDSPLPSVSPALSPVRSPTPPAAGFQPLLNGSLVPVPPTTPAP 709
            ..:...:.: ::.|....|..|......|.:...|   |....|:|.....|.......|:....
  Fly   934 AGSGSDESV-SISSSFNSPKQQQQLRSQSFNRHGS---SSNISASGNIKNNNYKAHKGKPSNQNG 994

Human   710 GVQLDVEALIPTHDEQGRPIPEWKRQVMVRKMQLK----MQEEEEQRRKLTAASSCCYPREGWRY 770
            |...|.|.:....:|..:...:.::..:.::.||:    .|::::|:::..........|...|.
  Fly   995 GGDHDYEDIYLVREESRKQHQQQQQHQLQQQQQLQHQATQQQQQQQQQQQQLQHKYNVGRSRSRD 1059

Human   771 SREHNAILGPFGELMTEADILRIEQQIENLQVLHKAQKLEARLEQLELELEQLLPISAALSAPRF 835
            |..|:..........|:..:......:.|.:.::....:..       ....:...|::.:....
  Fly  1060 SGSHSRSASASSTRSTDIVLQYSNHHLNNKRNMNNNSNMNN-------SSSNIAQSSSSNNNNNS 1117

Human   836 TVDPRRMHGRAASLPAWCSKISTLLK--------NMATLLAALGGRPAHLAELLTADTGQPLAPL 892
            .::..:.|   :.:....||..:.||        |:...|.. ||        :.:||.:.:.|.
  Fly  1118 LLNRNKSH---SIIGLHSSKYESSLKDNYSAKNVNLKNQLLN-GG--------IKSDTYESVCPP 1170

Human   893 PDAPWLPGPLCLGRSHSLSWCREAVA------------REILECGVSVQHLRATYELRARGAAPA 945
            .|....     ..::|..|..|..:|            ..|...|......:::..|:...:||
  Fly  1171 EDVAER-----TKQTHKNSMIRNNLADASSNNNTSGSINNISNIGNMNGGNQSSRNLKRVSSAP- 1229

Human   946 RCPRRK-------PPQSAGAPGREPILEEDYVAARSG----QPSAAAAHGPLVDWEPLG-TLGPP 998
              |.:.       ||.....|.|.|:.::     |:.    ||::...:..:......| ..||.
  Fly  1230 --PMQNLAVVNGPPPPPLPPPLRAPVQQQ-----RNNLSVDQPNSMTGNNGIYKKNVFGPNQGPT 1287

Human   999 EVQDRQAALPEPEQLARRPPLCTKLRGVQDYLDLRKERIVYLFLEHWRRWACRGPGRRAQARLRG 1063
            .......|.|.|  :....|:.|:.......|::.:|                 |..|....:||
  Fly  1288 NANGTGGAAPPP--VPAPNPVATEAVDSDSGLEVVEE-----------------PSLRPSELVRG 1333

Human  1064 LLPR-VAAAGAGPGLEATDAPRLPASNSEAHSPDERLRQLLRQRQAVGKLL-GHWRSL------- 1119
            ...| ::...|....:..:|.....|:..|.|.|.:.|.......|.|... ||:...
  Fly  1334 NHNRTMSTISANKKAKLLNAGSTNGSSIAASSDDSQSRYGGSVHAANGSAANGHFYGYSEGNKNQ 1398

Human  1120 ----------------LRRVPASPGLAHGLYWPQHFLPPLDGG---APPHYDSLTLDLFMLGYFQ 1165
                            ....|..|..|.|  .|..:.|.|.||   |..||:
  Fly  1399 GSNGNGNGNGNGGGGNYHSHPNQPHYATG--QPHQYTPSLYGGGSSAEDHYE------------- 1448

Human  1166 LLEMGLSREERKF---RHLLCYEMFDRLGSHPWERIRLFHR-VVLEEVEAGRRGWS-DGFEDL-- 1223
                 |::::::.   .||   ....|.|..     .|.:: :||..|.......| ||...|
  Fly  1449 -----LTQQQQQIYGETHL---PSGQRTGGP-----NLVNKQLVLPFVPPSFPNKSQDGVTHLIK 1500

Human  1224 -RHRFFGNGLEAEPAPEE-QAKEKEEEGKEQERTEEAAPFQTGDPPEGQPEALAP---------A 1277
             ........::....|.. ::.:.|:..:.|...:::.|.|....|...|....|         .
  Fly  1501 PSEYLKSISIDKRSCPSSARSTDTEDYMQIQIAQQQSHPHQHQHHPHPHPHPHHPHQLHGMGEQP 1565

Human  1278 PQPPPPP----------PPAAPP--------------------PTSDSPGSEAPA----EDPLEL 1308
            |.|||||          ||..||                    |...:|.|:..|    ..||..
  Fly  1566 PLPPPPPPLPHGMLPPQPPMGPPMGVAGGQDATMSGKSHKPKKPHGSAPNSQDTATRKQHQPLSA 1630

Human  1309 VS 1310
            :|
  Fly  1631 IS 1632

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ESPN	XP_011540533.1	ANKYR	2..277	CDD:440430	94/326 (29%)
		ANK repeat	39..67	CDD:293786	9/48 (19%)
		ANK repeat	69..101	CDD:293786	6/45 (13%)
		ANK repeat	103..135	CDD:293786	6/31 (19%)
		ANK repeat	137..169	CDD:293786	9/59 (15%)
		ANK repeat	171..203	CDD:293786	17/31 (55%)
		PLN03192	<196..365	CDD:215625	59/168 (35%)
		ANK repeat	239..269	CDD:293786	19/29 (66%)
		ANK repeat	271..302	CDD:293786	12/30 (40%)
		WH2	627..652	CDD:460490	3/24 (13%)
f	NP_001036284.1	ANK repeat	371..399	CDD:293786	10/27 (37%)
		ANKYR	<558..695	CDD:440430	69/150 (46%)
		ANK repeat	566..595	CDD:293786	16/28 (57%)
		ANK repeat	597..629	CDD:293786	13/31 (42%)
		ANK repeat	631..660	CDD:293786	18/28 (64%)
		ANK repeat	663..691	CDD:293786	12/41 (29%)