Protein Alignment ESPN and ZK792.4

DIOPT Version :10

• Sequence 1: XP_011540533.1
• Gene: ESPN / 83715
• HGNCID: 13281
• Length: 1341
• Species: Homo sapiens
• Sequence 2: NP_001023619.1
• Gene: ZK792.4 / 178102
• WormBaseID: WBGene00014077
• Length: 510
• Species: Caenorhabditis elegans
• Alignment Length: 371
• Identity: 72/371 - (19%)
• Similarity: 127/371 - (34%)
• Gaps: 139/371 - (37%)

Human   280 SFRRWSYLGVQRIWITTSQW---DVITIKKDFNLDFFHGTLTFAHHKVEVAKFRNFMQTRNPAKY 341
            |||....|....:.:..|.|   |...:|:. ::.||    ....|:..:::   :.:.|..|..
 Worm   118 SFRTRRKLADCAVLVEQSWWKLLDFAELKRS-SISFF----DIEKHETAISR---WSRARTRAAK 174

Human   342 PVKFFESVLGWNYFNCSISKNSN----LMDHFIFNNTLEWI-ALNKYDMVLSEEGYNLYNAVYAV 401
            ..|             .:|||..    .:.|:     ||.| ..::|       |:||
 Worm   175 VGK-------------GLSKNGKAQKLALQHW-----LEAIDPRHRY-------GHNL------- 207

Human   402 AHTYHELILQQTESQNIAEPNGVFIDCQQVASLLKTRVFTNPVGELVNMKHR------EKQCVEY 460
             |.|:...| ..:|:   ||...::|..:              |:.||:..:      ::||::|
 Worm   208 -HFYYNKWL-HCQSR---EPFFYWLDIGE--------------GKEVNLVEKCPRLKLQQQCIKY 253

Human   461 DIFITWNFPEGLG--------LKVKIGSYFPCFPQSQQLHISEDLE-----W----ATG------ 502
                       ||        :.|:.|.:|  :..|.::..:.|:|     |    :|.
 Worm   254 -----------LGPMERKAYEVVVEDGKFF--YKHSGEILQTSDMEDSESKWIFVLSTSKVLYVG 305

Human   503 ----GTSPQVPSSMCSATCTAGFRKI-------------HQKQTADCCFDCVQ-CPENEVSNETD 549
                ||..........||..||...:             |.:.|.:...|.:. ..||:| :.||
 Worm   306 KKKKGTFQHSSFLAGGATVAAGRLVVENGVLKAVWPHSGHYQPTEENFMDFLSFLRENDV-DITD 369

Human   550 MEQCVRCPDD--MYA---------NLEQTQCLQRTVSFLAYDDPLG 584
            ::......|:  :|.         :||:....::|:||....||.|
 Worm   370 VKMSPTDEDEFSIYKQRSTHMRNHSLEEDLEAEKTISFQDKVDPSG 415

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ESPN	XP_011540533.1	ANKYR	2..277	CDD:440430
		ANK repeat	39..67	CDD:293786
		ANK repeat	69..101	CDD:293786
		ANK repeat	103..135	CDD:293786
		ANK repeat	137..169	CDD:293786
		ANK repeat	171..203	CDD:293786
		PLN03192	<196..365	CDD:215625	17/91 (19%)
		ANK repeat	239..269	CDD:293786
		ANK repeat	271..302	CDD:293786	7/24 (29%)
		WH2	627..652	CDD:460490
ZK792.4	NP_001023619.1	TRPV	29..>121	CDD:454755	2/2 (100%)
		ANK repeat	66..97	CDD:293786
		ANKYR	85..366	CDD:440430	60/320 (19%)
		ANK repeat	99..135	CDD:293786	4/16 (25%)
		ANK repeat	176..204	CDD:293786	9/52 (17%)
		ANK repeat	206..238	CDD:293786	12/57 (21%)
		ANK repeat	240..273	CDD:293786	8/45 (18%)
		ANK repeat	275..312	CDD:293786	6/36 (17%)
		ANK repeat	314..345	CDD:293786	4/30 (13%)