Protein Alignment ESPN and espn

DIOPT Version :10

• Sequence 1: XP_011540533.1
• Gene: ESPN / 83715
• HGNCID: 13281
• Length: 1341
• Species: Homo sapiens
• Sequence 2: XP_012822811.2
• Gene: espn / 100379704
• XenbaseID: XB-GENE-960582
• Length: 1343
• Species: Xenopus tropicalis
• Alignment Length: 1419
• Identity: 794/1419 - (55%)
• Similarity: 955/1419 - (67%)
• Gaps: 154/1419 - (10%)

Human     1 MALEQALQAARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAA 65
            |.||:.|||||||:::.|||||..|.:.|..:||:.|..||||||.|||.|||:||:||.|....
 Frog     1 MTLERILQAARQGDVETLRSLHTLGQIQPDAKDPMGASAVHHAARGGKLSCLRYLVDEAQLVGNC 65

Human    66 RARNGATPAHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGD 130
            ||||||||||||:|||:|:||||||:||||..:||||||||:|||||||||.|:.:|||..|..|
 Frog    66 RARNGATPAHDAAATGNLSCLQWLLTQGGCDFEDKDNSGATILHLAARFGHHEITSWLLRFGTND 130

Human   131 PTAATDMGALPIHYAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQEC 195
            ....||.||||:||||||||.|:|:.|:|:.|..:|:||||||||||||||||||||.||||::|
 Frog   131 AMVPTDTGALPVHYAAAKGDLPTLQHLLEYCPNAINSQTKNGATPLYLACQEGHLEVIQYLVKDC 195

Human   196 GADPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLSWLL 260
            ||||..||:|||||||||||||||.|||||:|.||:|||::|.||||||||||||||.|||||||
 Frog   196 GADPQMRANDGMTPLHAAAQMGHSTVIVWLMSFTDISLSDKDDDGATAMHFAASRGHAKVLSWLL 260

Human   261 LHGGEISADLWGGTPLHDAAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNGHSHCTRYLR 325
            ||||||..|.|||||||||||||||||||||||||.:|.:||.||||||||:::|||.||.:|||
 Frog   261 LHGGEICTDNWGGTPLHDAAENGELECCQILVVNGIKLGIRDLDGYTAADLAEYNGHFHCAKYLR 325

Human   326 TVENLSVEHRVLSRDPSAELEAKQPDSGMSSPNTTVSVQPLNFDLSSPTSTLSNYDSCSSSHSSI 390
            ||||:|||||||||||||::|.|||||||||||||:|.||.:||:.||:|||||||||:||.||:
 Frog   326 TVENMSVEHRVLSRDPSADIELKQPDSGMSSPNTTMSTQPAHFDIGSPSSTLSNYDSCNSSQSSV 390

Human   391 ---KGQHPPCGLSS---ARAADIQSYMDMLNPELGLPRGTIGKPTPPPPPPSFPPPPPPPGTQLP 449
               |.||.  ||.|   ....|:|:|||||:||:...:|. ....||||||:|||||||......
 Frog   391 GDKKNQHE--GLGSRPPETITDMQAYMDMLDPEVNPKKGD-SSVIPPPPPPTFPPPPPPASDSRL 452

Human   450 PPPPGYPAPKPPVGPQAADIYMQTKNKLRHVETEALKKELSSCDGHDGLRRQDSSRKPRAFSKQP 514
            ||||.||||.||.|...::||:|.||.||||:.|....|.|.    :||||.||.|:.|.|:|||
 Frog   453 PPPPCYPAPSPPEGQHTSEIYVQAKNNLRHVDNELPSSENSP----EGLRRADSCRRSRNFNKQP 513

Human   515 STGDYYRQLGRCPGETLAARPG----MAHSEEAALLPGNHVPNGCAADPKASRELPPPPPPPPPP 575
            ||||||:.:.:...|...:...    ||||||.::.....|.||     ..|..:  ||||.|||
 Frog   514 STGDYYKYIEQSTTEKSTSETSQVKKMAHSEEGSVKSSETVQNG-----NISGNV--PPPPLPPP 571

Human   576 LPEAASSPPPAPPLPLESA-GPGCGQRRSSSSTGKVRVLRHRKSTKSFNMMSPTGDNSELLAEIK 639
            |||....|||.||||.||: .....|||||:|||         ||||||||||||||||||||||
 Frog   572 LPENLCFPPPPPPLPTESSIICSSSQRRSSNSTG---------STKSFNMMSPTGDNSELLAEIK 627

Human   640 AGKSLKPTPQSKGLTTVFSGIGQ-------------PAFQPDSPLPSV---SPALSPVRSPTPPA 688
            ||||||||||||||||||||.||             |...|.:||.:.   :.|:|....|..|
 Frog   628 AGKSLKPTPQSKGLTTVFSGSGQHGPNAEVHISTTPPPSSPSTPLGNTVISTAAVSNSGGPKSP- 691

Human   689 AGFQPLLNGSLVPVPPTTPAPGVQLDVEALIPTHDEQGRPIPEWKRQVMVRKMQLKMQEEEEQRR 753
               :|||||:..|:....|:   |||||:|||||||||||||||||||||||:|||:|||||::|
 Frog   692 ---EPLLNGNSSPLAQAQPS---QLDVESLIPTHDEQGRPIPEWKRQVMVRKLQLKIQEEEEKKR 750

Human   754 KLTAASSCCYPREGWRYSREHNAILGPFGELMTEADILRIEQQIENLQVLHKAQKLEARLEQLEL 818
            ...|.|  .|..||||||..||||||||||||||:||.|||:|||||||:||.||:|..|||||.
 Frog   751 TFEAGS--YYQHEGWRYSHAHNAILGPFGELMTESDINRIEKQIENLQVMHKVQKVETELEQLEH 813

Human   819 ELEQLLPISAALSAPRFTVDPRRMHGRAASLPAWCSKISTLLKNMATLLAALGGRPAHLAELLTA 883
            ||:||||:||||:...|||:|::|.|||..|||||||||||||:||.|||.|||:.|.|.:|:|.
 Frog   814 ELQQLLPVSAALAQEHFTVNPKQMQGRAEDLPAWCSKISTLLKSMAILLATLGGKEADLTDLVTH 878

Human   884 DTGQ-PLAPLPDAPWLPGPLCLGRSHSLSWCREAVAREILECGVSVQHLRATYELRAR----GAA 943
            :|.: |.:|:.|     |...:|||.|.|..||.|.:||.:|||||::|:|.|||.|:    ..|
 Frog   879 ETQERPQSPVKD-----GGTNIGRSQSFSSTREEVEKEIKQCGVSVKNLKANYELFAQPHNDSEA 938

Human   944 PARCPRRKPPQSAGAP----GREPILEEDYVAARSG----QPSAAAAHG--PLVDWEPL----GT 994
            .:|..:||.....|..    |||||||||||.....    .......||  |::....|    ..
 Frog   939 SSRIYKRKRSLPVGTNGYGYGREPILEEDYVTTNDQFHVLTEDIPRMHGEAPIIPHSQLTYQDED 1003

Human   995 LGPPEVQDRQA-----ALPEP----EQLARRPPLCTKLRGVQDYLDLRKERIVYLFLEHWRRWAC 1050
            :.|.|::....     ||.||    :.:.|..|:.|:|..||||:|:|||||||||||||::|..
 Frog  1004 IFPREIETGNKSTIMDALGEPLLSEDHMTRSLPVQTELSCVQDYIDMRKERIVYLFLEHWKKWTF 1068

Human  1051 RGPGRRAQARLRGLLPRVAAAGAGPGLEATDAPRLPASNSEAH------------SPDERLRQLL 1103
            ....:.:..:.:|:          .|||.||   |.:...|..            |.|:||...:
 Frog  1069 TESIKNSNTKRKGM----------HGLENTD---LGSEKDEVEGEDGRLKMCKGSSDDDRLLYFM 1120

Human  1104 RQRQAVGKLLGHWRSLLRRVPASP----GLAHGLYWPQHFLPPLDGGAPPHYDSLTLDLFMLGYF 1164
            :|||.|||||.||||::.:||...    ...:.:|||:||||.:: |....|.||||||||||||
 Frog  1121 KQRQVVGKLLSHWRSIICQVPTRQIRRLSRTNMIYWPEHFLPHVN-GVQVEYSSLTLDLFMLGYF 1184

Human  1165 QLLEMGLSREERKFRHLLCYEMFDRLGSHPWERIRLFHRVVLEEVEAGRRGWSDGFEDLRHRFFG 1229
            |||||.:|||||||||:||||||||||||.||.||.||:.|:||:|||:|.|||||||::.|:||
 Frog  1185 QLLEMNMSREERKFRHILCYEMFDRLGSHNWELIRSFHKTVMEEIEAGKRDWSDGFEDIKQRYFG 1249

Human  1230 NGLEAEPAPEEQAKEKEEEGKEQERTEEAAPFQTGDPPEGQPEALAPAP-------QPPPPPPPA 1287
            :.:.......::..:.||...:.|..:|                 ||.|       .|...|...
 Frog  1250 DSVVGGFEGFKEIGQLEETDLQTESNQE-----------------APVPLDIQIKETPVVSPDEL 1297

Human  1288 APPPTSDSPGSEAPAEDPLELVSEMGEFSNEDICRYIDRSFSFWKEKEAELFDI 1341
            .|||.|        .:|.::||||:|||:|:|||||||||||||||||||:|||
 Frog  1298 KPPPKS--------RKDSIQLVSELGEFTNDDICRYIDRSFSFWKEKEAEMFDI 1343

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ESPN	XP_011540533.1	ANKYR	2..277	CDD:440430	196/274 (72%)
		ANK repeat	39..67	CDD:293786	17/27 (63%)
		ANK repeat	69..101	CDD:293786	24/31 (77%)
		ANK repeat	103..135	CDD:293786	19/31 (61%)
		ANK repeat	137..169	CDD:293786	18/31 (58%)
		ANK repeat	171..203	CDD:293786	26/31 (84%)
		PLN03192	<196..365	CDD:215625	137/168 (82%)
		ANK repeat	239..269	CDD:293786	27/29 (93%)
		ANK repeat	271..302	CDD:293786	26/30 (87%)
		WH2	627..652	CDD:460490	24/24 (100%)
espn	XP_012822811.2	Ank_4	2..56	CDD:372654	31/53 (58%)
		ANK repeat	6..33	CDD:293786	14/26 (54%)
		ANK repeat	35..67	CDD:293786	18/31 (58%)
		ANKYR	52..324	CDD:440430	203/271 (75%)
		ANK repeat	69..101	CDD:293786	24/31 (77%)
		ANK repeat	103..127	CDD:293786	17/23 (74%)
		ANK repeat	138..169	CDD:293786	18/30 (60%)
		ANK repeat	171..203	CDD:293786	26/31 (84%)
		ANK repeat	205..269	CDD:293786	54/63 (86%)
		ANK repeat	271..302	CDD:293786	26/30 (87%)
		WH2	615..640	CDD:460490	24/24 (100%)
		Mdv1_N	<780..818	CDD:472421	27/37 (73%)