DRSC/TRiP Functional Genomics Resources

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Protein Alignment RPS6KL1 and TPK2

DIOPT Version :10

Sequence 1:XP_011535508.1 Gene:RPS6KL1 / 83694 HGNCID:20222 Length:603 Species:Homo sapiens
Sequence 2:NP_015121.1 Gene:TPK2 / 855898 SGDID:S000006124 Length:380 Species:Saccharomyces cerevisiae


Alignment Length:436 Identity:90/436 - (20%)
Similarity:152/436 - (34%) Gaps:177/436 - (40%)


- Green bases have known domain annotations that are detailed below.


Human   163 DLAVLPRLVSNSLPQVQLVQDPATGGTFVVKSLPRCHMV----------SRERLTIIPHGVPYMT 217
            |..::..|.:.|..:|.||:....|..:.:|.|.:..:|          .|..|.::.|  |::.
Yeast    69 DFQIMRTLGTGSFGRVHLVRSVHNGRYYAIKVLKKQQVVKMKQVEHTNDERRMLKLVEH--PFLI 131

Human   218 KLLRYFVSEDSIFLHLEHVQGGTLWSHLLSQAHSRHSGLSSGSTQERMKAQLNPHLNLLTPARLP 282
            ::...|....:||:.:::::||.|:|.|                   .|:|           |.|
Yeast   132 RMWGTFQDARNIFMVMDYIEGGELFSLL-------------------RKSQ-----------RFP 166

Human   283 SGHAPGQDRIALEPPRTSPNLLLAGEAPSTRPQREAEGEPTARTSTSGSSDLPKAPGGHLHLQAR 347
            :                                                                
Yeast   167 N---------------------------------------------------------------- 167

Human   348 RAGQNSDAGPPRGLTWVPEGAGPVLGGCGRGMDQSCLSADGAGRGCGRATWSVREEQVKQWAAEM 412
                                  ||                                 .|.:|||:
Yeast   168 ----------------------PV---------------------------------AKFYAAEV 177

Human   413 LVALEALHEQGVLCRDLHPGNLLLDQAGHIRLTYFGQWSEVEP---QCCGEAVDNLYSAPEVGGI 474
            ::|||.||...::.|||.|.|:|||:.|||::|.||...||:.   ..||...   |.||||...
Yeast   178 ILALEYLHAHNIIYRDLKPENILLDRNGHIKITDFGFAKEVQTVTWTLCGTPD---YIAPEVITT 239

Human   475 SELTEACDWWSFGSLLYELLTG------MALSQSHPSGIQAHTQLQLPEWLSRPAASLLTELLQF 533
            ....::.||||.|.|:||:|.|      ....:::...:|.  ::..|.:.......||::|:..
Yeast   240 KPYNKSVDWWSLGVLIYEMLAGYTPFYDTTPMKTYEKILQG--KVVYPPYFHPDVVDLLSKLITA 302

Human   534 EPTRRLGMGEGGVSKLKSHPFFSTIQWSKLVGALVLLSGTHFPPVT 579
            :.|||:|..:.|...:|:||:||.:.|.:|:...:  ...:.||:|
Yeast   303 DLTRRIGNLQSGSRDIKAHPWFSEVVWERLLAKDI--ETPYEPPIT 346

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RPS6KL1XP_011535508.1 MIT_SNX15 48..122 CDD:239140
STKc_RPK118_like 148..555 CDD:270728 83/410 (20%)
TPK2NP_015121.1 STKc_PKA_like 69..358 CDD:270732 90/436 (21%)
Blue background indicates that the domain is not in the aligned region.

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