Protein Alignment RPS6KL1 and CBK1

DIOPT Version :10

• Sequence 1: XP_011535508.1
• Gene: RPS6KL1 / 83694
• HGNCID: 20222
• Length: 603
• Species: Homo sapiens
• Sequence 2: NP_014238.3
• Gene: CBK1 / 855561
• SGDID: S000005105
• Length: 756
• Species: Saccharomyces cerevisiae
• Alignment Length: 693
• Identity: 124/693 - (17%)
• Similarity: 209/693 - (30%)
• Gaps: 313/693 - (45%)

Human    23 RSQAHVYLEQIRNR----------VALGVPDMTKRDYLV-------------DAATQIRLALERD 64
            :.|.|:.::|.:.:          |..|..:.|..:|:.             |.|..::|.:|
Yeast   229 QQQQHMQIQQQQQQQQQQQQSQSPVQSGFNNGTISNYMYFERRPDLLTKGTQDKAAAVKLKIE-- 291

Human    65 VSEDYEAAFNHYQNGVDVLLRGIHVDPNKERREAVKLKITKYLRRAEEIFNCHLQRPLSSGASPS 129
                     |.||:.|...:.      ..|||..::.::|.: ..:||    ...|.|||.....
Yeast   292 ---------NFYQSSVKYAIE------RNERRVELETELTSH-NWSEE----RKSRQLSSLGKKE 336

Human   130 AGFSSLRLRPIRTLSSAVEQLRGCRVVGVIEKRDLAVLPRLVSNSLPQVQLVQDPATGGTFVVKS 194
            :.|  ||||..|.   ::|.....:|:|              ..:..:|:|||...||..:.:|:
Yeast   337 SQF--LRLRRTRL---SLEDFHTVKVIG--------------KGAFGEVRLVQKKDTGKIYAMKT 382

Human   195 LPRCHM--------VSRERLTIIPHGVPYMTKLLRYFVSEDSIFLHLEHVQGGTLWSHLLSQAHS 251
            |.:..|        |..||..:.....|::..|...|.....::|.:|.:.||.|.:.|:
Yeast   383 LLKSEMYKKDQLAHVKAERDVLAGSDSPWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLI----- 442

Human   252 RHSGLSSGSTQERMKAQLNPHLNLLTPARLPSGHAPGQDRIALEPPRTSPNLLLAGEAPSTRPQR 316
                                                                             
Yeast   443 ----------------------------------------------------------------- 442

Human   317 EAEGEPTARTSTSGSSDLPKAPGGHLHLQARRAGQNSDAGPPRGLTWVPEGAGPVLGGCGRGMDQ 381
                                                                             
Yeast   443 ----------------------------------------------------------------- 442

Human   382 SCLSADGAGRGCGRATWSVREEQVKQ-WAAEMLVALEALHEQGVLCRDLHPGNLLLDQAGHIRLT 445
                           .|.:..|.|.: :.||.::|:|.:|:.|.:.||:.|.|:|:|..|||:|:
Yeast   443 ---------------RWQLFTEDVTRFYMAECILAIETIHKLGFIHRDIKPDNILIDIRGHIKLS 492

Human   446 YFG------------------QWSEV-----EPQCCGE------------AVDNL---------- 465
            .||                  |..|.     :|.....            .||::
Yeast   493 DFGLSTGFHKTHDSNYYKKLLQQDEATNGISKPGTYNANTTDTANKRQTMVVDSISLTMSNRQQI 557

Human   466 -------------------YSAPEVGGISELTEACDWWSFGSLLYELLTGM------ALSQSHPS 505
                               |.|||:.......:.|||||.|:::||.|.|.      ...:::..
Yeast   558 QTWRKSRRLMAYSTVGTPDYIAPEIFLYQGYGQECDWWSLGAIMYECLIGWPPFCSETPQETYRK 622

Human   506 GIQAHTQLQLPE--WLSRPAASLLTELLQFEPTRRLGMGEGGVSKLKSHPFFSTIQWSKL----- 563
            .:.....||.|:  .:|..|..|:..||. ...:|||. .||..::||||||..:.|:.:
Yeast   623 IMNFEQTLQFPDDIHISYEAEDLIRRLLT-HADQRLGR-HGGADEIKSHPFFRGVDWNTIRQVEA 685

Human   564 --VGALVLLSGTHFPPVTDLHR-----GMASL----QELSRQG 595
              :..|..::.|.|.|..:|..     .||..    :::::||
Yeast   686 PYIPKLSSITDTRFFPTDELENVPDSPAMAQAAKQREQMTKQG 728

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RPS6KL1	XP_011535508.1	MIT_SNX15	48..122	CDD:239140	16/86 (19%)
		STKc_RPK118_like	148..555	CDD:270728	81/487 (17%)
CBK1	NP_014238.3	MobB_CBK1	269..341	CDD:439268	19/95 (20%)
		STKc_NDR_like_fungal	350..748	CDD:270778	93/545 (17%)