Protein Alignment RPS6KL1 and YPK1

DIOPT Version :10

• Sequence 1: XP_011535508.1
• Gene: RPS6KL1 / 83694
• HGNCID: 20222
• Length: 603
• Species: Homo sapiens
• Sequence 2: NP_012796.1
• Gene: YPK1 / 853733
• SGDID: S000001609
• Length: 680
• Species: Saccharomyces cerevisiae
• Alignment Length: 529
• Identity: 110/529 - (20%)
• Similarity: 173/529 - (32%)
• Gaps: 205/529 - (38%)

Human    67 EDYEAAFNHYQNGVDVLLRGIHVDPNKERREAVKLKITKYLRRAEEIFNCHLQRPLSSGASPSAG 131
            |..:..|:...:..|:.|...|:..|.....|..::          ::| |....|.:|.....
Yeast   277 EKLQTIFDKINSNQDIHLDSFHLPINLSFDSAASIR----------LYN-HHWITLDNGLGKIN- 329

Human   132 FSSLRLRPIRTLSSAVEQLRGCRVVGVIEKRDLAVLPRLVSNSLPQVQLVQDPATGGTFVVKSLP 196
             .|:..:|.|....:::.....:|:|              ..|..:|..|:...|...:.:|::.
Yeast   330 -ISIDYKPSRNKPLSIDDFDLLKVIG--------------KGSFGKVMQVRKKDTQKVYALKAIR 379

Human   197 RCHMVSR--------ERLTIIPHGVPYMTKLLRYFVSEDSIFLHLEHVQGGTLWSHLLSQAHSRH 253
            :.::||:        ||..:.....|::..|...|.|.:.::..|..:.||.|:.||
Yeast   380 KSYIVSKSEVTHTLAERTVLARVDCPFIVPLKFSFQSPEKLYFVLAFINGGELFYHL-------- 436

Human   254 SGLSSGSTQERMKAQLNPHLNLLTPARLPSGHAPGQDRIALEPPRTSPNLLLAGEAPSTRPQREA 318
                                                                         |:|
Yeast   437 -------------------------------------------------------------QKE- 439

Human   319 EGEPTARTSTSGSSDLPKAPGGHLHLQARRAGQNSDAGPPRGLTWVPEGAGPVLGGCGRGMDQSC 383
                       |..||.:|
Yeast   440 -----------GRFDLSRA---------------------------------------------- 447

Human   384 LSADGAGRGCGRATWSVREEQVKQWAAEMLVALEALHEQGVLCRDLHPGNLLLDQAGHIRLTYFG 448
                                  :.:.||:|.||:.||:..|:.|||.|.|:|||..|||.|..||
Yeast   448 ----------------------RFYTAELLCALDNLHKLDVVYRDLKPENILLDYQGHIALCDFG 490

Human   449 ------QWSEVEPQCCGEAVDNLYSAPEVGGISELTEACDWWSFGSLLYELLTGMA--LSQSHPS 505
                  :..:.....||...   |.|||:......|:|.|||:.|.||||:|||:.  ..:..|.
Yeast   491 LCKLNMKDDDKTDTFCGTPE---YLAPELLLGLGYTKAVDWWTLGVLLYEMLTGLPPYYDEDVPK 552

Human   506 GIQAHTQ--LQLPEWLSRPAASLLTELLQFEPTRRLGMGEGGVSKLKSHPFFSTIQWSKLVGALV 568
            ..:...|  |..|:...|.|..||..||..:||||||.  .|..::::|||||.:.|.:|
Yeast   553 MYKKILQEPLVFPDGFDRDAKDLLIGLLSRDPTRRLGY--NGADEIRNHPFFSQLSWKRL----- 610

Human   569 LLSGTHFPP 577
            |:.| :.||
Yeast   611 LMKG-YIPP 618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RPS6KL1	XP_011535508.1	MIT_SNX15	48..122	CDD:239140	9/54 (17%)
		STKc_RPK118_like	148..555	CDD:270728	87/424 (21%)
YPK1	NP_012796.1	YPK1_N_like	116..342	CDD:212165	14/77 (18%)
		Protein Kinases, catalytic domain	352..663	CDD:473864	96/441 (22%)