Protein Alignment RPS6KL1 and YPK3

DIOPT Version :10

• Sequence 1: XP_011535508.1
• Gene: RPS6KL1 / 83694
• HGNCID: 20222
• Length: 603
• Species: Homo sapiens
• Sequence 2: NP_009584.1
• Gene: YPK3 / 852316
• SGDID: S000000232
• Length: 525
• Species: Saccharomyces cerevisiae
• Alignment Length: 645
• Identity: 128/645 - (19%)
• Similarity: 198/645 - (30%)
• Gaps: 270/645 - (41%)

Human    30 LEQIRNRVALGVPDMTKRDYLVDAATQIRLALERDVSED------YEAAFNH---YQNGVDVLLR 85
            |::..:||:|   |..|.|..||.::    |:..|::.:      ||.:.||   :.|.:.  |.
Yeast     5 LDEELHRVSL---DDKKNDIKVDYSS----AIYNDINHEQGSSITYEESINHLSVHSNAIP--LN 60

Human    86 GIHVDPNKERREAVKLKITKYLRRAEEIFNCHLQRPLSSGASPSAGFSSLRLRPIR--------- 141
            |:.......||.:...|..             :..|.::......|..::|....|
Yeast    61 GMSPAHRMRRRSSAYSKFP-------------ILTPPNTRRFSITGSDAMRTNTNRLSITPQDII 112

Human   142 -------TLSSAVEQLRGCRVVGVIEKRDLAVLPRLVSNSLPQVQLVQDPATGGTFVVKSLPRCH 199
                   .||..:...:..||:|              ..:..:|.||:|..|...:.:|.|.:..
Yeast   113 SSNIGENELSRNLHDFKPVRVLG--------------QGAYGKVLLVKDVNTSKLYAMKQLRKAE 163

Human   200 MVSRERLTIIPH---------------GVPYMTKLLRYFVSEDSIFLHLEHVQGGTLWSHLLSQA 249
            ::..:..|....               |   ::|.|....:|.||...:||       .:::...
Yeast   164 ILISQTATDSKREDEDKNDGNNNDNDDG---LSKRLERTFAERSILSEIEH-------PNIVKLF 218

Human   250 HSRHSGLSSGSTQERMKAQLNPHLNLLTPARLPSGHAPGQDRIALEPPRTSPNLLLAGEAPSTRP 314
            :|.|.               |..|.||
Yeast   219 YSFHD---------------NSKLYLL-------------------------------------- 230

Human   315 QREAEGEPTARTSTSGSSDLPKAPGGHLHLQARRAGQNSDAGPPRGLTWVPEGAGPVLGGCGRGM 379
                               |...|||.|....:..|
Yeast   231 -------------------LQYIPGGELFYHLKEHG----------------------------- 247

Human   380 DQSCLSADGAGRGCGRATWSVREEQVKQWAAEMLVALEALHEQGVLCRDLHPGNLLLDQAGHIRL 444
                               ::.|..|..:|||:..||..||.:||:.|||.|.|.||:|.||:.|
Yeast   248 -------------------TLDETTVSFYAAEISCALRFLHTKGVVYRDLKPENCLLNQRGHLVL 293

Human   445 TYFG---------QWSEVEPQCCGEAVDNLYS--------APEVGGISELTEACDWWSFGSLLYE 492
            |.||         ...|.:|    |.|:.|||        |||:......::.|||:|.|.|||:
Yeast   294 TDFGLSKKSANDSAVDEEDP----ENVNALYSIIGTPEYCAPEILLGKAYSQNCDWYSLGCLLYD 354

Human   493 LLTGMA--LSQSHP---SGIQAHTQ-LQLPEWLSRPAASLLTELLQFEPTRRLGM---------- 541
            :|.|..  ...:|.   :.||.:.| .::|.:||.....:|..||:.|..:|..:
Yeast   355 MLVGKPPYTGSNHKVIINKIQQNKQGPKIPFYLSEGMKDILNALLKKETAKRWNVDKYWAKTGAN 419

Human   542 -----------GEGGVSKLKSHPFFSTIQWSKL---------VGALVLLSGTHFPPVTDL 581
                       |....|....|..|..|.|..|         :|.:|       |.:|||
Yeast   420 NKPTKSKKKKSGAARTSLFTEHFIFRKIDWKLLESGQLQKTTLGPIV-------PVITDL 472

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RPS6KL1	XP_011535508.1	MIT_SNX15	48..122	CDD:239140	15/82 (18%)
		STKc_RPK118_like	148..555	CDD:270728	91/465 (20%)
YPK3	NP_009584.1	STKc_AGC	134..406	CDD:270693	85/419 (20%)
		S_TK_X	445..516	CDD:214529	9/35 (26%)