Protein Alignment RPS6KL1 and KIN82

DIOPT Version :10

• Sequence 1: XP_011535508.1
• Gene: RPS6KL1 / 83694
• HGNCID: 20222
• Length: 603
• Species: Homo sapiens
• Sequence 2: NP_010015.3
• Gene: KIN82 / 850453
• SGDID: S000000687
• Length: 720
• Species: Saccharomyces cerevisiae
• Alignment Length: 569
• Identity: 115/569 - (20%)
• Similarity: 189/569 - (33%)
• Gaps: 236/569 - (41%)

Human    64 DVSEDYEAAFNH---YQNG-----VDVLLRGIHVD-PNKE---RREAVKLKITKYLRR-AEEIFN 115
            |::|:.|....|   .:||     .::.|....:| |.|.   |::.:.:.||..||| |.|.||
Yeast   209 DINENEELQNFHRKISENGSASPLANLSLSNSPIDSPRKNSETRKDQIPMNITPRLRRAASEPFN 273

Human   116 -----------CHLQRPLSSGASPSAG--FSSLRLRPIRTLS--SAVEQLRGCRVVGVIEKRDLA 165
                       ..|::|      ||.|  ....|.|.:||.|  :..:.:       .:|.:...
Yeast   274 TAKDGLMREDYIALKQP------PSLGDIVEPRRSRRLRTKSFGNKFQDI-------TVEPQSFE 325

Human   166 VLPRLVSNSLPQVQLVQDPATGGTFVVKSLPRCHMVSRER----------LTIIPHGVPYMTKLL 220
            .:..|....:.:|.||::..|...|.:|.|.:..|:.|::          |....|  |::..|.
Yeast   326 KIRLLGQGDVGKVYLVRERDTNQIFALKVLNKHEMIKRKKIKRVLTEQEILATSDH--PFIVTLY 388

Human   221 RYFVSEDSIFLHLEHVQGGTLWSHLLSQAHSRHSGLSSGSTQERMKAQLNPHLNLLTPARLPSGH 285
            ..|.::|.::|.:|:..||                       |..:|
Yeast   389 HSFQTKDYLYLCMEYCMGG-----------------------EFFRA------------------ 412

Human   286 APGQDRIALEPPRTSPNLLLAGEAPSTRPQREAEGEPTARTSTSGSSDLPKAPGGHLHLQARRAG 350
                                                                      ||.|::
Yeast   413 ----------------------------------------------------------LQTRKS- 418

Human   351 QNSDAGPPRGLTWVPEGAGPVLGGCGRGMDQSCLSADGAGRGCGRATWSVREEQVKQWAAEMLVA 415
                                           .|::                ||..|.:|:|::.|
Yeast   419 -------------------------------KCIA----------------EEDAKFYASEVVAA 436

Human   416 LEALHEQGVLCRDLHPGNLLLDQAGHIRLTYFGQWSEVEPQCCGEAVDNL--------------- 465
            ||.||..|.:.|||.|.|:||.|:||:.|:.|    ::..|..|.....:
Yeast   437 LEYLHLLGFIYRDLKPENILLHQSGHVMLSDF----DLSIQATGSKKPTMKDSTYLDTKICSDGF 497

Human   466 ----------YSAPEVGGISELTEACDWWSFGSLLYELLTGMA------LSQSHPSGIQAHTQLQ 514
                      |.||||...:..|.|.|||:.|.|:||:|.|..      .:::..:.:....:..
Yeast   498 RTNSFVGTEEYLAPEVIRGNGHTAAVDWWTLGILIYEMLFGCTPFKGDNSNETFSNILTKDVKFP 562

Human   515 LPEWLSRPAASLLTELLQFEPTRRLGMGEGGVSKLKSHPFFSTIQWSKL 563
            ..:.:|:....|:.:||.....:||| .:.|.:.:|.||||..:|||.|
Yeast   563 HDKEVSKNCKDLIKKLLNKNEAKRLG-SKSGAADIKRHPFFKKVQWSFL 610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RPS6KL1	XP_011535508.1	MIT_SNX15	48..122	CDD:239140	21/81 (26%)
		STKc_RPK118_like	148..555	CDD:270728	79/447 (18%)
KIN82	NP_010015.3	STKc_phototropin_like	322..623	CDD:270726	84/443 (19%)