Protein Alignment RPS6KL1 and CG7156

DIOPT Version :10

• Sequence 1: XP_011535508.1
• Gene: RPS6KL1 / 83694
• HGNCID: 20222
• Length: 603
• Species: Homo sapiens
• Sequence 2: NP_650697.1
• Gene: CG7156 / 42187
• FlyBaseID: FBgn0038588
• Length: 681
• Species: Drosophila melanogaster
• Alignment Length: 632
• Identity: 185/632 - (29%)
• Similarity: 260/632 - (41%)
• Gaps: 185/632 - (29%)

Human     6 CECLPSP-------GLEP-EP-CSRAR----SQA---HVYLE---QIRNRVALGVPDMTKRDYL- 50
            |:.|..|       |:.| :| |.:.:    |||   .:.||   :.:..|||     ||||||
  Fly   168 CDKLDLPYDPHDAGGITPLDPRCDKEQTNNESQAKETEIELETKQEPKTDVAL-----TKRDYLR 227

Human    51 ----------------VDAATQIRLALERDVSEDYEAAFNHYQNGVDVLLRGIHVDPNKERREAV 99
                            .:||.:...|::.:|:.:|..|...|::|||:||.|...|.::|||...
  Fly   228 LLTPMASIESDDSDYIYEAALEFSHAVQAEVNLEYAEAHERYKHGVDLLLNGAKQDSSEERRFIA 292

Human   100 KLKITKYLRRAEEIF------NC---HLQRPLSSGASPSAGFSSLRLRPIRTLSSAVEQLRGCRV 155
            |.||.|||.|||||.      :|   .||..||...:.....|.        |.....||...:|
  Fly   293 KAKIAKYLARAEEIHANFLANDCPTKKLQFQLSLDTTDGGSVSH--------LECPWNQLARYKV 349

Human   156 VGVIEKRDLAVLPRLVSNSLPQVQLV---QDPATGGTFVVKSL--PRCHMVSRERLTIIPHGVPY 215
            :.:::.|            :.|||.|   |.||.    ::|.:  |..|.:::.  ..:|..|||
  Fly   350 LQILQDR------------VMQVQCVTKSQQPAA----IMKGVEKPASHSLTQS--IFLPQQVPY 396

Human   216 MTKLLRYFVSEDSIFLHLEHVQGGTLWSHLLSQAHSRHSGLSSGSTQERMKAQLNPHLNLLTPAR 280
            |.:||.||.||..|||.|...:||.|:.:|.|                            .||
  Fly   397 MVQLLAYFQSEQKIFLLLRQAEGGMLYDYLQS----------------------------YTP-- 431

Human   281 LPSGHAPGQDRIALEPPRTSPNLLLAGEA-PSTRPQREAEGEPTARTSTSGSSDLPKAPGGHLHL 344
                              ||...:..||. ||.:...|.|.|....||.|..|||.:: ...|..
  Fly   432 ------------------TSSKSVNYGELFPSDQEPEEKEAEEPPLTSDSDVSDLVRS-SQQLLK 477

Human   345 QARRAGQNSDAG---PPRGLTWVPEGAGPVLGGCGRGMDQSCLSADGAGRGCGRATWSVREEQVK 406
            .......|..||   |.|                .:.:||:.:.:.           .:.|:.::
  Fly   478 SVTNTLSNLQAGVVTPKR----------------NKKVDQNRIRSK-----------PIPEQCLR 515

Human   407 QWAAEMLVALEALHEQGVLCRDLHPGNLLLDQAGHIRLTYF----GQWSE---VEPQCCGEAVDN 464
            |||.|:.:|:.:||.:||:.||||.||:||...|.:.||||    |..|:   |......|||.|
  Fly   516 QWACELAIAIHSLHGKGVILRDLHMGNILLGAKGQLLLTYFYQNEGLTSDDNYVHKALNLEAVAN 580

Human   465 LYSAPEVGGISELTEACDWWSFGSLLYELLTGMALSQSHPSGIQAHTQLQLPE---WLSRPAASL 526
            .:.|||    ..||...||||:|.:||:||.|:....:||..:..:..:|.|.   .:|..|..|
  Fly   581 HFVAPE----RPLTFRSDWWSYGVVLYQLLLGVPYKVTHPGQLDLYGCVQYPSESLEISDHAKDL 641

Human   527 LTELLQFEPTRRLGMGEGGVSKLKSHPFFSTIQWSKLVGALVLLSGT 573
            |.:|||..|..||     ...:|::||||..|.|.     .||..||
  Fly   642 LEQLLQLSPELRL-----DYDQLQAHPFFKGIDWQ-----AVLEQGT 678

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RPS6KL1	XP_011535508.1	MIT_SNX15	48..122	CDD:239140	34/99 (34%)
		STKc_RPK118_like	148..555	CDD:270728	121/425 (28%)
CG7156	NP_650697.1	PX_SNX15_like	8..124	CDD:132791
		MIT_SNX15	241..315	CDD:239140	28/73 (38%)
		Protein Kinases, catalytic domain	343..665	CDD:473864	121/424 (29%)