Protein Alignment RPS6KL1 and rskd-1

DIOPT Version :10

• Sequence 1: XP_011535508.1
• Gene: RPS6KL1 / 83694
• HGNCID: 20222
• Length: 603
• Species: Homo sapiens
• Sequence 2: NP_506082.2
• Gene: rskd-1 / 179685
• WormBaseID: WBGene00010096
• Length: 848
• Species: Caenorhabditis elegans
• Alignment Length: 607
• Identity: 145/607 - (23%)
• Similarity: 248/607 - (40%)
• Gaps: 119/607 - (19%)

Human    21 RARSQAHVYLEQIRNRVALGVPDMTKRDYLVDAATQIRLALERDVSEDYEAAFNHYQNGVDVLLR 85
            |.|...|..:|          .:.|..||||.|...:..|...:....||.||..|::....|::
 Worm   234 RLRGSTHHNIE----------IEETPADYLVTAGQLVATAQRAEEEHAYELAFQCYKSAASSLIQ 288

Human    86 GIHVDPNKERREAVKLKITKYLRRAEEIFNCHLQRPLSSGASPSAGFSSLRLRP--IRTLSSAVE 148
            |:|::.:..:|.||:.|..|||.:||:::..:|.  |........|..:..::.  |.....:.:
 Worm   289 GVHIESDMTKRNAVRRKTAKYLVKAEKLYRTYLS--LDGSVFNFEGLLTAAMQDPNILAFQCSNK 351

Human   149 QLRGCRVVGVIEKRDLAVLPRLVSNSLPQVQLVQDPATGGTFVVKSLPRCHMVSRERLTIIPHGV 213
            .::..|.:||:.:.|......||..::.:        :...:|:|.:.: .:.|.:....:|..:
 Worm   352 SMKNYRFIGVLPELDAERKVILVEETIGE--------SNKKYVMKLIEK-GVPSSDCSIFLPTNI 407

Human   214 PYMTKLLRYFVSEDSIFLHLEHVQGGTLWSHL---LSQAHSRH--------SGLSSGSTQERMKA 267
            |:|.:|:::|.:|..|.|.||.|:.|.|||.|   ..:|.|||        :.:..|.|...:..
 Worm   408 PHMVQLVQFFETETHIILLLEFVEPGQLWSFLRRMFDEAESRHVLWLAELKADVRDGDTTSEVTV 472

Human   268 QLNPHLNLLTPARLPSGHAPGQDRI--------ALEPPRTSPNLLLAGEAPSTRP---------- 314
            |:..:.......||........:|:        :.|.|.....|...||.|:.|.
 Worm   473 QITKNEGNYRGRRLLFTVGVDYERVVEMRDESFSSEKPSDESLLCTVGEDPTGRSDAPTGDFTIA 537

Human   315 --QREA--------EGEPTARTSTSGSSDLPKAPGGHLHLQARRAGQNSDAGPPRGLTWVPEGAG 369
              .|||        |.|..|......||...::|.|:     |.:.:|.:..|         .:.
 Worm   538 GNSREAAESHYFQVEEESPAAVKFDFSSSKSQSPRGN-----RISSENQNHSP---------SSS 588

Human   370 PVLGGCGRGMDQSCLSADGAGR-------------------GCGRATWS---VREEQVKQWAAEM 412
            .|:     .:|    |||.:..                   ...|..|:   :.|..:..|:|::
 Worm   589 KVV-----KLD----SADSSNSKEMFLKNLWKALQTVQKQLSLRRRVWNYLDLPESLIVHWSAQI 644

Human   413 LVALEALH-EQGVLCRDLHPGNLLLDQAGHIRLTYFGQWSEVEPQCCGEAVDNLYSAPEVGGIS- 475
            :.....|| |......|.:..::|:|..|::.:||.|:|.|...:   :.:.:.|||||.....
 Worm   645 VSFFFVLHAEHHEFIGDFNADDILIDSDGNLLMTYIGRWYETNRR---KRLTDGYSAPESSQYGW 706

Human   476 ELTEACDWWSFGSLLYELLTGMALSQSHPSGIQAHTQLQLPE--WLSRPAASLLTELLQFEPTRR 538
            |.|...|.|:.|:||:|:|.|.:|:.:.|.|:..:.:|.:||  .:|..|..||..||...|..|
 Worm   707 EPTPESDIWTLGALLFEMLCGRSLANAAPHGVLRNMELPIPEKVVVSFVAKDLLNMLLVPTPALR 771

Human   539 LGMGEGGVSKLKSHPFFSTIQW 560
            ..:.|     :::||||..|.|
 Worm   772 PSLDE-----IRAHPFFRHIDW 788

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RPS6KL1	XP_011535508.1	MIT_SNX15	48..122	CDD:239140	24/73 (33%)
		STKc_RPK118_like	148..555	CDD:270728	109/471 (23%)
rskd-1	NP_506082.2	PX_SNX15_like	26..150	CDD:132791
		MIT_SNX15	251..324	CDD:239140	24/74 (32%)
		Protein Kinases, catalytic domain	<408..>450	CDD:473864	17/41 (41%)
		Protein Kinases, catalytic domain	<601..783	CDD:473864	49/189 (26%)