Protein Alignment RPS6KL1 and rps6kl1

DIOPT Version :10

• Sequence 1: XP_011535508.1
• Gene: RPS6KL1 / 83694
• HGNCID: 20222
• Length: 603
• Species: Homo sapiens
• Sequence 2: XP_021328892.1
• Gene: rps6kl1 / 101886230
• ZFINID: ZDB-GENE-111020-10
• Length: 690
• Species: Danio rerio
• Alignment Length: 704
• Identity: 263/704 - (37%)
• Similarity: 339/704 - (48%)
• Gaps: 201/704 - (28%)

Human    44 MTKRDYLVDAATQIRLALERDVSEDYEAAFNHYQNGVDVLLRGIHVDPNKERREAVKLKITKYLR 108
            |.|:|||:|||.|||:||:|:|:|||||||::|:||||:||.|:.||||||||||||.|.|:||:
Zfish     1 MAKKDYLLDAAQQIRMALDREVNEDYEAAFSYYKNGVDLLLNGVQVDPNKERREAVKRKTTQYLK 65

Human   109 RAEEIFNCHLQRPLSSGASPSAGFSSLRLRPIRTLSSAVEQLRGCRVVGVIEKRDLAVLPRLVSN 173
            ||||||..:||..:|.|::...|:||||.|.||.|||.||.|..|:|.|||:|
Zfish    66 RAEEIFISYLQDNISKGSTHLGGYSSLRFRSIRHLSSPVENLAMCKVTGVIDK------------ 118

Human   174 SLPQVQLVQDPATGGTFVVKSLPRCHMVSRERLTIIPHGVPYMTKLLRYFVSEDSIFLHLEHVQG 238
                |..|:......||:|||||:....||||.||||.|||:|.|||:|:||||::||||||:||
Zfish   119 ----VLTVESLINKETFIVKSLPKSSWESRERSTIIPQGVPFMVKLLKYYVSEDTVFLHLEHLQG 179

Human   239 GTLWSHL---LSQAHSRHSGLSSGSTQE------------RMKAQLNPHLNLLTPA--------- 279
            |.|:|.|   .|:|...:....|.:..:            |....||......:|.
Zfish   180 GRLFSRLHRVRSEAIREYPECFSPNQHKIYLKNSYTLPVLRQNTYLNEDYGRTSPPANHRLENCN 244

Human   280 ----------------------------------RLPSGHAP----------------------G 288
                                              .||..:||                      |
Zfish   245 PRSYCEDVGCQQTGSPSVFASDGLPSVGVPNGLNSLPQDNAPLPIHPCVIVDTRDPLDVTSDLLG 309

Human   289 QD----RI-----------ALEP--------------------PRTSPNLLLAGEAP-------S 311
            .|    ||           ||||                    .:.:|:.|....|.       :
Zfish   310 NDVRIERIDSCVDLSKAWGALEPAQDCRGFTGSNSDILGFRIAAQITPSTLFGANAQPILCSTVN 374

Human   312 TRPQREAEGEPTARTSTSGSSDLP-------KAPGG-----HLH-LQARR-----AGQNSDAGPP 358
            ..||| ....|.|.|........|       :.|.|     ..| :.:.|     ..||.|....
Zfish   375 VLPQR-VRIIPNASTKHQAHDGFPHEHNSPHRRPSGQQFVTEFHKVSSHRYSFECTPQNQDGFTL 438

Human   359 RGLTWVPEGAGPVLG---GC---GRGMDQ------SCLSADGAGRGC------------------ 393
            ........|....||   .|   .....|      ||.||......|
Zfish   439 EFTNMTSRGNSGDLGKQDNCQFFSHSFTQPEVSMISCPSASTTNSACWSETYLEAGHRVNVAGLE 503

Human   394 -----------GRATWSVR---EEQVKQWAAEMLVALEALHEQGVLCRDLHPGNLLLDQAGHIRL 444
                       .:|.|..|   |::|:.|.|::|:|||:|||||::|:||:|.|:||..:|...|
Zfish   504 SKPQINTKNVGAKAKWGRRGLPEDEVRLWGAQILLALESLHEQGIVCQDLNPRNILLRSSGEACL 568

Human   445 TYFGQWSEVEPQCCGEAVDNLYSAPEVGGISELTEACDWWSFGSLLYELLTGMALSQSHPSGIQA 509
            ||||||:||:|:...:|::.:|.|||:||:|::||||||||||:|||||||||.|.|.||:|:..
Zfish   569 TYFGQWTEVQPEINPKAMEEMYCAPEIGGVSKVTEACDWWSFGALLYELLTGMPLWQCHPAGVHP 633

Human   510 HTQLQLPEWLSRPAASLLTELLQFEPTRRLGMGEGGVSKLKSHPFFSTIQWSKL 563
            ||.|.:||:||..|.|||||||||:...|||.|.||||.:|.|||||.:.|.||
Zfish   634 HTPLHIPEFLSTAATSLLTELLQFDACYRLGSGGGGVSDIKCHPFFSAVPWLKL 687

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RPS6KL1	XP_011535508.1	MIT_SNX15	48..122	CDD:239140	52/73 (71%)
		STKc_RPK118_like	148..555	CDD:270728	189/590 (32%)
rps6kl1	XP_021328892.1	MIT_SNX15	5..78	CDD:239140	52/72 (72%)
		Protein Kinases, catalytic domain	105..>186	CDD:473864	48/96 (50%)
		Protein Kinases, catalytic domain	<524..679	CDD:473864	91/154 (59%)