Protein Alignment TLN2 and SLA2

DIOPT Version :10

• Sequence 1: NP_055874.2
• Gene: TLN2 / 83660
• HGNCID: 15447
• Length: 2542
• Species: Homo sapiens
• Sequence 2: NP_014156.2
• Gene: SLA2 / 855478
• SGDID: S000005187
• Length: 968
• Species: Saccharomyces cerevisiae
• Alignment Length: 1110
• Identity: 232/1110 - (20%)
• Similarity: 394/1110 - (35%)
• Gaps: 278/1110 - (25%)

Human  1548 LDGDFSEDNRNKCRI-ATAPLIEAVENLTAF-----ASNPEFVSIPA-QISSEGSQAQEPILVSA 1605
            :|.|..:..:..|.: .|||..:.|.....:     :|...|.::.. .::::..|..:.::|..
Yeast     4 IDSDLQKALKKACSVEETAPKRKHVRACIVYTWDHQSSKAVFTTLKTLPLANDEVQLFKMLIVLH 68

Human  1606 KTMLESSSYLIRTARSLAINPKDPPTWSVLAGHSHTVSDSIKSLITSIRDKAPGQRECDYSID-- 1668
            |.:.|...    :|.:.||..:|   |....|..|:...|...||...      .|.....:|
Yeast    69 KIIQEGHP----SALAEAIRDRD---WIRSLGRVHSGGSSYSKLIREY------VRYLVLKLDFH 120

Human  1669 ----GINRCIRDIEQ-ASLAAVSQSLATRDDISVEALQEQLTSVVQEIGHLIDPIATAARGEAAQ 1728
                |.|....:.|: .||.:||.     .|...|.:.: |.|:...:......|..:.:.|...
Yeast   121 AHHRGFNNGTFEYEEYVSLVSVSD-----PDEGYETILD-LMSLQDSLDEFSQIIFASIQSERRN 179

Human  1729 LGHKVTQLASYFEPLILAAVGVASKILD-----HQQQMTVLDQTKTLAESALQMLYAAKEGGGNP 1788
            ...|::.|.    |||..:.|:...|..     |:|    |:..:  .::|||.|....|
Yeast   180 TECKISALI----PLIAESYGIYKFITSMLRAMHRQ----LNDAE--GDAALQPLKERYE----- 229

Human  1789 KAQHTH-----------DAITEAAQLMKEAVDDIMVTLNEAASEVGLVGGMVDAIAEAMSKLDE- 1841
             .||..           ..:|....:.|..||         |.:|.|:.. ||...|...|..|
Yeast   230 -LQHARLFEFYADCSSVKYLTTLVTIPKLPVD---------APDVFLIND-VDESKEIKFKKREP 283

Human  1842 -------------GTPP-------EPKGTFVDYQTTVVKYSKAIAVTAQE-MMTKSVT------- 1878
                         .|||       .|:.......:|...|.:.:...|.. ||..:.|
Yeast   284 SVTPARTPARTPTPTPPVVAEPAISPRPVSQRTTSTPTGYLQTMPTGATTGMMIPTATGAANAIF 348

Human  1879 -------NPEELGGLASQMTSDYGHLAFQ--GQMAAATAEPEEIGFQIRTRVQDLGHGCIFLVQK 1934
                   .|:......:|..::...|..:  .|:....|:.|....|::...||:.:   ..:|:
Yeast   349 PQATAQMQPDFWANQQAQFANEQNRLEQERVQQLQQQQAQQELFQQQLQKAQQDMMN---MQLQQ 410

Human  1935 AGALQ---VCPTDSYTKRELIECARAVTEKVSLVLSAL---------QAGNKGTQACITAATAVS 1987
            ....|   :..|:.|.|.:.:  .:...::|..:.|.:         |..||..|        ::
Yeast   411 QNQHQNDLIALTNQYEKDQAL--LQQYDQRVQQLESEITTMDSTASKQLANKDEQ--------LT 465

Human  1988 GIIADLDTTIMFATAGTLNAENSETFADHRENILKTAKALVEDTKLLVSGAASTPDKLAQAAQSS 2052
            .:...||  :......:|....|:...:|. |:|...|.|    :|.|:.|..:..|..|.....
Yeast   466 ALQDQLD--VWERKYESLAKLYSQLRQEHL-NLLPRFKKL----QLKVNSAQESIQKKEQLEHKL 523

Human  2053 AATITQLAEVVKLGAASLGSDDPETQVVLINAIKDVAKALSDLISATKGAASKPVDDPSMYQLKG 2117
            .....|:||:||        |....::.|..:|.:   |.:|..:||..|.:...|
Yeast   524 KQKDLQMAELVK--------DRDRARLELERSINN---AEADSAAATAAAETMTQD--------- 568

Human  2118 AAKVMVTNVTSLLKTVKAVEDEATRGTRALEATIECIKQELTVFQSKDVPEKTSSP--------- 2173
                   .:..:|..:             ||:.|..|::.:   .:.|.|...|.|
Yeast   569 -------KMNPILDAI-------------LESGINTIQESV---YNLDSPLSWSGPLTPPTFLLS 610

Human  2174 ------EESIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRKAVSDMLTACKQ---ASFHPDV 2229
                  |.:..............:|.|:   |.:||...:....:::.::|..|.   .:...:.
Yeast   611 LLESTSENATEFATSFNNLIVDGLAHGD---QTEVIHCVSDFSTSMATLVTNSKAYAVTTLPQEQ 672

Human  2230 SDEVRTRALRFGTECTLGYLDLL---------EHVLVILQKPTPEFKQQLAAFSKRVAGAVTELI 2285
            ||::.|...|...|....:.||:         |....|:.....:.:::|...|..:...:.  |
Yeast   673 SDQILTLVKRCAREAQYFFEDLMSENLNQVGDEEKTDIVINANVDMQEKLQELSLAIEPLLN--I 735

Human  2286 QAAEAMKGTEWVDPEDPTVIAETELLGAAASIEAAAKKLEQLKPRAKPKQADETLDFEEQILEAA 2350
            |:.::.|.|.          ..:||:..|..|   .|..|.|:           :|..:.:|..|
Yeast   736 QSVKSNKETN----------PHSELVATADKI---VKSSEHLR-----------VDVPKPLLSLA 776

Human  2351 KSIAAATSALVKSASAAQRELVAQGKVGSIPANA--ADDGQWSQGLISAARMVAAATSSLCEAAN 2413
            ..|..|..||||:|...|.|:..   ..|||.|.  ..:.:|::||||||:.||.||:.|...|:
Yeast   777 LMIIDAVVALVKAAIQCQNEIAT---TTSIPLNQFYLKNSRWTEGLISAAKAVAGATNVLITTAS 838

Human  2414 ASVQG----HASEEKLISSAKQVAASTAQLLVACKVKADQDSEAMRRLQAAGNAVKRASDNLVRA 2474
            ..:..    :.|.|:.|.::|:|||||.||:.|.:||....|:|..:|:.....|..|    .|:
Yeast   839 KLITSEDNENTSPEQFIVASKEVAASTIQLVAASRVKTSIHSKAQDKLEHCSKDVTDA----CRS 899

Human  2475 AQKAAFGKADDD--------------DVVVKTKFVGGIAQIIAAQEEMLKKERELEEARKKLAQI 2525
            ......|..:||              :..:||      |: :..|.|:||.|:.|..|||:|.:|
Yeast   900 LGNHVMGMIEDDHSTSQQQQPLDFTSEHTLKT------AE-MEQQVEILKLEQSLSNARKRLGEI 957

Human  2526 RQQQY 2530
            |:..|
Yeast   958 RRHAY 962

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TLN2	NP_055874.2	FERM_F0_TLN2	4..87	CDD:340692
		FERM_F1_TLN2	88..199	CDD:340694
		FERM_M	203..316	CDD:459788
		Interaction with PIP5K1C. /evidence=ECO:0000250	312..406
		FERM_C_Talin	312..403	CDD:269973
		Talin_middle	494..655	CDD:462691
		I_LWEQ	689..>765	CDD:460265
		talin-RS	1045..>1174	CDD:213393
		talin-RS	1656..1827	CDD:213393	39/193 (20%)
		VBS	1850..1974	CDD:430312	23/152 (15%)
		ILWEQ	2337..2532	CDD:214607	68/214 (32%)
SLA2	NP_014156.2	ANTH	7..269	CDD:400137	61/305 (20%)
		DR0291	420..>546	CDD:441187	30/150 (20%)
		ILWEQ	763..965	CDD:214607	69/225 (31%)