DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CASP3 and Drice

DIOPT Version :9

Sequence 1:	NP_001341706.1	Gene:	CASP3 / 836	HGNCID:	1504	Length:	277	Species:	Homo sapiens
Sequence 2:	NP_524551.2	Gene:	Drice / 43514	FlyBaseID:	FBgn0019972	Length:	339	Species:	Drosophila melanogaster

Alignment Length:	283	Identity:	111/283 - (39%)
Similarity:	161/283 - (56%)	Gaps:	21/283 - (7%)

- Green bases have known domain annotations that are detailed below.

Human     1 MENTENSVDSKSIKNLEPKII--HGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTS 63
            :.|..:|..|...||:...:.  |.:|           |.|.:...|:.:|.|:::|...| :.|
  Fly    59 LANGYSSPSSSYRKNVAKMVTDRHAAE-----------YNMRHKNRGMALIFNHEHFEVPT-LKS 111

Human    64 RSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIF 128
            |:||:||..||....:.|.:||....|...::|:..:...:.::||.....:..:|||||.|.|:
  Fly   112 RAGTNVDCENLTRVLKQLDFEVTVYKDCRYKDILRTIEYAASQNHSDSDCILVAILSHGEMGYIY 176

Human   129 GTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGI-----ETDSGVDDDMACHKIP 188
            ..:....|..|.:||..:.|.||.||||||.||||:|..||.|:     :|::..|..|: :|||
  Fly   177 AKDTQYKLDNIWSFFTANHCPSLAGKPKLFFIQACQGDRLDGGVTMQRSQTETDGDSSMS-YKIP 240

Human   189 VEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFD 253
            |.||||.||||.||:|||||:..||||:|||||.|.....:|:.:.:||.|.::||.:|||.:.|
  Fly   241 VHADFLIAYSTVPGFYSWRNTTRGSWFMQSLCAELAANGKRLDILTLLTFVCQRVAVDFESCTPD 305

Human   254 A-TFHAKKQIPCIVSMLTKELYF 275
            . ..|.:||||||.:|||:.|.|
  Fly   306 TPEMHQQKQIPCITTMLTRILRF 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASP3	NP_001341706.1	CASc	37..277	CDD:214521	104/245 (42%)
Drice	NP_524551.2	CASc	86..330	CDD:214521	104/245 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147030
Domainoid	1	1.000	199	1.000	Domainoid score	I3057
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	210	1.000	Inparanoid score	I3668
Isobase	1	0.950	-	0	Normalized mean entropy	S5027
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D417543at33208
OrthoFinder	1	1.000	-	-		FOG0000242
OrthoInspector	1	1.000	-	-		mtm8526
orthoMCL	1	0.900	-	-		OOG6_103710
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3066
SonicParanoid	1	1.000	-	-		X460
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.640