Protein Alignment CASP3 and Damm

DIOPT Version :10

• Sequence 1: NP_004337.2
• Gene: CASP3 / 836
• HGNCID: 1504
• Length: 277
• Species: Homo sapiens
• Sequence 2: NP_523703.2
• Gene: Damm / 36266
• FlyBaseID: FBgn0033659
• Length: 255
• Species: Drosophila melanogaster
• Alignment Length: 280
• Identity: 77/280 - (27%)
• Similarity: 125/280 - (44%)
• Gaps: 66/280 - (23%)

Human     2 ENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSG 66
            :..|...||..: |.||           |..||.:.|:..|.:   .|:|::.|.:.:.: :|.|
  Fly    10 QKIERLYDSNRV-NAEP-----------GQGLDLNEKLKPPAV---YILNHEQFPQDSQL-NRKG 58

Human    67 TDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGE--EGIIFG 129
            :..|...||:||.:||..|...::....::...:::.|.:..::.:.||..:||||:  |.|:..
  Fly    59 SSNDVNALRKTFESLKCRVEVISNPALPDVKNKVKEWSAKRFTQDAGFVLFILSHGDRKEKILAC 123

Human   130 TNGPVDLKKITNF--FRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEAD 192
            .:....|.....|  ||..   :|:||||:.|:|||:|                      |:.||
  Fly   124 DHREYHLDDDVLFPLFRNP---TLSGKPKILIVQACKG----------------------PLRAD 163

Human   193 --------FLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFM----HILTRVNRK--- 242
                    ::..||.:.||.|:||...||.|||:||..:.||....:|.    |:...|.|:
  Fly   164 AKKMNNEPYIKCYSCSEGYLSYRNENHGSVFIQTLCEAMDQYGLTRDFQSIFKHVKAEVERRSTM 228

Human   243 -----VATEFESFSFDATFH 257
                 |.:| ||.:||..|:
  Fly   229 TGSKQVPSE-ESHNFDKPFY 247

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CASP3	NP_004337.2	CASc	37..277	CDD:214521	68/245 (28%)
Damm	NP_523703.2	Peptidase_C14	42..247	CDD:425803	65/231 (28%)