DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GPR101 and dop-4

DIOPT Version :9

Sequence 1:	NP_473362.1	Gene:	GPR101 / 83550	HGNCID:	14963	Length:	508	Species:	Homo sapiens
Sequence 2:	NP_508238.2	Gene:	dop-4 / 183715	WormBaseID:	WBGene00016872	Length:	517	Species:	Caenorhabditis elegans

Alignment Length:	491	Identity:	108/491 - (21%)
Similarity:	207/491 - (42%)	Gaps:	53/491 - (10%)

- Green bases have known domain annotations that are detailed below.

Human     4 TCTNSTRESNSSHTCMPLSKMPISLAHGIIRSTVLVIFLAASFVGNIVLALVLQRKPQLLQVTNR 68
            |.|.|....|.:..........|...|.::...:..|.| .:..||.::.:.:..|..|...|..
Worm    16 TMTPSVSTENDTTVWATEEPAAIVWRHPLLAIALFSICL-LTVAGNCLVVIAVCTKKYLRNPTGY 79

Human    69 FIFNLLVTDLLQISLVAP----WVVATSVPLFWPLNSHFCTALVSLTHLFAFASVNTIVVVSVDR 129
            .|.:|.:.||:...:|.|    :.:|...   |......|....::..|.:.||:..:.|:|:||
Worm    80 LIISLAIADLIVGVIVMPMNSLFEIANHT---WLFGLMMCDVFHAMDILASTASIWNLCVISLDR 141

Human   130 YLSIIHPLSYPSKMTQRRGYLLLYGTWIVAILQSTPPLYGWGQAA--FDERNALCSMIWGASPSY 192
            |::...|:.|..|:::||..:.:...|:::.:.|.|.:..|..::  ..|..:.|  ::..|..|
Worm   142 YMAGQDPIGYRDKVSKRRILMAILSVWVLSAILSFPGIIWWRTSSPHLYEDQSQC--LFTDSKMY 204

Human   193 -TILSVVSFIVIPLIVMIACYSVVF-CAARRQHALLYNVKRHSLEVRVKDCVENEDEEGAEKKEE 255
             :..|:||| .|||.:::..|..|: .|.|....:...:|..|::.|          .|  ||..
Worm   205 VSFSSLVSF-YIPLFLILFAYGKVYIIATRHSKGMRMGIKTVSIKKR----------NG--KKSN 256

Human   256 FQDESEFRRQHEGEVKAKEGRMEAKDGSLK-----AKEGS----TGTSESSVEARGSEEVRESST 311
            .:.||....::|..::...||.:....||:     |:|.:    ...|..|:..||  |...::|
Worm   257 TETESILSSENEPTLRIHFGRGKQSSSSLRNSRFHARESTRLLLKQVSCKSLNDRG--EHNNNNT 319

Human   312 VASDGSMEGKEG--STKVEENSMKADKGR--TEVNQCSIDLGEDDMEFGEDDINFSEDDVEAVNI 372
            |... .:.|.||  |..:..:|.:..:||  |..:.||..|.:.|.   .|.::.|.:....:..
Worm   320 VRQP-LLRGTEGCHSDSISRSSQRNFRGRNVTIGSNCSSTLLQVDQ---PDRMSLSSNSQMVMTS 380

Human   373 PESLPPSRRNSN----SNPPLPRCYQCKAAKVIFIIIFSYVLSLGPYCFLAVLAVWVDVETQVPQ 433
            |.|   :||..|    |...:...::.:||:.:.|::.:::|...|:.....|..:.:......:
Worm   381 PLS---TRRKLNVREKSRQMMRYVHEQRAARTLSIVVGAFILCWTPFFVFTPLTAFCESCFSNKE 442

Human   434 WVITIIIWLFFLQCCIHPYVYGYMHKTIKKEIQDML 469
            .:.|.:.|...|...::|.:|....:..::..:.:|
Worm   443 TIFTFVTWAGHLNSMLNPLIYSRFSRDFRRAFKQIL 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GPR101	NP_473362.1	7tm_1	48..>222	CDD:278431	46/181 (25%)
		FCP1_C	<243..334	CDD:286402	24/101 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	244..338		24/104 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	476..508
dop-4	NP_508238.2	7tm_4	53..>245	CDD:304433	48/198 (24%)
dop-4	NP_508238.2	7tm_1	59..463	CDD:278431	98/430 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910