DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ODAD4 and CYC8

DIOPT Version :9

Sequence 1:	NP_113609.1	Gene:	ODAD4 / 83538	HGNCID:	25280	Length:	672	Species:	Homo sapiens
Sequence 2:	NP_009670.3	Gene:	CYC8 / 852410	SGDID:	S000000316	Length:	966	Species:	Saccharomyces cerevisiae

Alignment Length:	484	Identity:	101/484 - (20%)
Similarity:	162/484 - (33%)	Gaps:	165/484 - (34%)

- Green bases have known domain annotations that are detailed below.

Human    60 MGDLERSLKDAEASLQSDPAFCKGILQKAETLYTMGD-FEFALVFYHRGYKLRP---DREFRVG- 119
            :||.:|:....:|:||.:|:..|.:...|. ||...| |:.|...|.|...:.|   |....:|
Yeast    59 LGDGDRAAMAYDATLQFNPSSAKALTSLAH-LYRSRDMFQRAAELYERALLVNPELSDVWATLGH 122

Human   120 ----IQKAQEAINNSVGSPSSIKLENKGDLSFLSKQAENIKAQQKPQPMKHLLHPTKGEPK-WKA 179
                :...|.|.|                            |.|  |.:.||.:|  ..|| |..
Yeast   123 CYLMLDDLQRAYN----------------------------AYQ--QALYHLSNP--NVPKLWHG 155

Human   180 SLKSEKTVRQLLGELYVDKEYLEKLLLDEDLIKGTMKGGLTVEDLIMTGINYLDTHSNFWRQQKP 244
                       :|.|| |:                 .|.|...:.....:..||.|   :.:...
Yeast   156 -----------IGILY-DR-----------------YGSLDYAEEAFAKVLELDPH---FEKANE 188

Human   245 IYARERDRKLMQEKWLRDHKRRPSQTAHYILKS----LEDIDMLLTSGS---AEGSLQKAEKVLK 302
            ||.|.......|.||     .:..:...|||..    |::.|:....||   :.|..|.|::..:
Yeast   189 IYFRLGIIYKHQGKW-----SQALECFRYILPQPPAPLQEWDIWFQLGSVLESMGEWQGAKEAYE 248

Human   303 KVLEWNKEEVPNKDELVGNLYSCIGNAQIELGQMEAALQSHRKDLE-----------------IA 350
            .||..|:.......:| |.||   |.:.::....:.||....|.||                 |.
Yeast   249 HVLAQNQHHAKVLQQL-GCLY---GMSNVQFYDPQKALDYLLKSLEADPSDATTWYHLGRVHMIR 309

Human   351 KEYDLP-DAKSRALD----------NIGRVFARVGKFQQAIDTWEEKIPLAKTTLEKTWLFHEIG 404
            .:|... ||..:|::          :||.::.::.:::.|:|.:...|.| ...:.:.|  :::|
Yeast   310 TDYTAAYDAFQQAVNRDSRNPIFWCSIGVLYYQISQYRDALDAYTRAIRL-NPYISEVW--YDLG 371

Human   405 RCYLELDQAWQAQNYGEKSQQCAEEEGDIEWQLNASVLVAQAQVKLRDFESAVNNFEKALERAKL 469
            ..|                :.|..:..|        .|.|..|....|    |||
Yeast   372 TLY----------------ETCNNQLSD--------ALDAYKQAARLD----VNN---------- 398

Human   470 VHNNEAQQAIISALDDANKGIIRELRKTN 498
            ||..|..:|:...|:  |.|   .:.|:|
Yeast   399 VHIRERLEALTKQLE--NPG---NINKSN 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ODAD4	NP_113609.1	TPR 1. /evidence=ECO:0000255	13..46
		TPR_11	16..78	CDD:290150	6/17 (35%)
		TPR repeat	16..41	CDD:276809
		TPR repeat	46..76	CDD:276809	5/15 (33%)
		TPR 2. /evidence=ECO:0000255	48..80		7/19 (37%)
		TPR_11	49..112	CDD:290150	16/52 (31%)
		TPR 3. /evidence=ECO:0000255	81..114		10/36 (28%)
		TPR repeat	81..109	CDD:276809	9/28 (32%)
		TPR 4. /evidence=ECO:0000255	275..311		11/42 (26%)
		TPR repeat	311..349	CDD:276809	10/54 (19%)
		TPR_12	316..385	CDD:290160	19/96 (20%)
		TPR 5. /evidence=ECO:0000255	320..353		10/49 (20%)
		TPR 6. /evidence=ECO:0000255	360..393		7/42 (17%)
		TPR repeat	360..385	CDD:276809	5/34 (15%)
		TPR_12	361..429	CDD:290160	11/77 (14%)
		TPR 7. /evidence=ECO:0000255	397..430		4/32 (13%)
		TPR_12	398..468	CDD:290160	12/69 (17%)
		TPR repeat	431..465	CDD:276809	8/33 (24%)
		TPR 8. /evidence=ECO:0000255	437..470		7/32 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	527..672
CYC8	NP_009670.3	TPR	<38..142	CDD:223533	25/113 (22%)
		TPR repeat	46..74	CDD:276809	4/14 (29%)
		TPR repeat	80..108	CDD:276809	9/28 (32%)
		TPR	94..391	CDD:223533	76/396 (19%)
		TPR repeat	113..143	CDD:276809	8/59 (14%)
		TPR repeat	150..178	CDD:276809	9/56 (16%)
		TPR repeat	184..211	CDD:276809	6/31 (19%)
		TPR repeat	223..253	CDD:276809	8/29 (28%)
		TPR repeat	258..290	CDD:276809	8/35 (23%)
		TPR repeat	296..324	CDD:276809	5/27 (19%)
		TPR repeat	329..359	CDD:276809	5/29 (17%)
		TPR repeat	364..393	CDD:276809	8/54 (15%)
		Herpes_BLLF1	<697..944	CDD:282904
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900