DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Slc22a8 and CG33233

DIOPT Version :9

Sequence 1:	NP_112622.1	Gene:	Slc22a8 / 83500	RGDID:	632286	Length:	536	Species:	Rattus norvegicus
Sequence 2:	NP_995978.2	Gene:	CG33233 / 2769005	FlyBaseID:	FBgn0053233	Length:	489	Species:	Drosophila melanogaster

Alignment Length:	287	Identity:	71/287 - (24%)
Similarity:	121/287 - (42%)	Gaps:	54/287 - (18%)

- Green bases have known domain annotations that are detailed below.

  Rat    92 TEPCLDGWIYNSTRDTIVIEWDLVCSSNKLKEMAQSIFMAGILVGGPVIGELSDRFGRKPILTWS 156
            ||....|::...|.    .|:|   :|.|.|.:..:..:.|::..|..||.|:||:|||.::..:
  Fly    35 TESMTAGYLVVLTS----CEFD---TSPKEKTLLANSLLGGMVASGLFIGFLADRYGRKFVIRLA 92

  Rat   157 YLMLAASGSGAAFSPSLPVYMIFRFLCGCSISGI-SLSTVILN----VEWVPTSMRAISSTSIG- 215
            .:...:....:|..|.|....:.|.:.|..:|.: ||....|.    ::|.|.:: ||.|.|.|
  Fly    93 LVGALSFSVISALMPDLYSLSVIRIIVGTFLSAVASLQVGFLGEFHAIKWRPITV-AICSQSQGL 156

  Rat   216 ---YCYTIGQFILS-------GLAYAIPQWRWLQLTSSAPFFIFSLLSWW--------VPESIRW 262
               ||..:...||.       ..:|.:..||:|.:        |.::..|        |||:..:
  Fly   157 ALIYCPLVAMAILPNNFNVDLSSSYNLRVWRFLMM--------FFMIPGWLALVGICLVPETPHF 213

  Rat   263 LVLSGKYSKALKTLQRVATFNGKKEEGKKLTIEELKFNLQKDITSAK------VKYGLSDLFRVS 321
            |:...:..|||..|:.:...|.||.|...:|:.|     :|..|:.:      |.|....||...
  Fly   214 LMSVNRPDKALLALKWICRMNRKKWEDVDITLSE-----EKSSTNDQEGFWKTVWYEYKLLFSKP 273

  Rat   322 ILRRVTFCLSLAWFSTGFAYYSLAMGV 348
            .:.:...||.|.:   |..:.|:.:|:
  Fly   274 HVFKFFICLFLIF---GIFFTSIGLGI 297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc22a8	NP_112622.1	2A0119	11..503	CDD:273328	71/287 (25%)
		MFS	124..492	CDD:119392	62/255 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	515..536
CG33233	NP_995978.2	MFS_1	22..451	CDD:284993	71/287 (25%)
		MFS	23..>208	CDD:119392	45/188 (24%)
		MFS	354..>482	CDD:304372
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346984
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840