DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CASP2 and Drice

DIOPT Version :9

Sequence 1:	NP_116764.2	Gene:	CASP2 / 835	HGNCID:	1503	Length:	452	Species:	Homo sapiens
Sequence 2:	NP_524551.2	Gene:	Drice / 43514	FlyBaseID:	FBgn0019972	Length:	339	Species:	Drosophila melanogaster

Alignment Length:	254	Identity:	78/254 - (30%)
Similarity:	130/254 - (51%)	Gaps:	15/254 - (5%)

- Green bases have known domain annotations that are detailed below.

Human   192 YRLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQ 256
            |.::.:.||:||:.::.||. ...|:.|:|.:||...|..:.|.|.::|.|..|...:::...::
  Fly    86 YNMRHKNRGMALIFNHEHFE-VPTLKSRAGTNVDCENLTRVLKQLDFEVTVYKDCRYKDILRTIE 149

Human   257 NFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLFDNANCPSLQNKPKMFFIQACR 321
             :|....|..:|..:||:||||..|.||..|.: .:|..::..|...:||||..|||:||||||:
  Fly   150 -YAASQNHSDSDCILVAILSHGEMGYIYAKDTQ-YKLDNIWSFFTANHCPSLAGKPKLFFIQACQ 212

Human   322 GDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMICGYACLKGTAAMRNTKRGSWY 386
            ||..|.||..|..:.        |:|.  :.....::|..:|.:..|:.:.|..:.|||.||||:
  Fly   213 GDRLDGGVTMQRSQT--------ETDG--DSSMSYKIPVHADFLIAYSTVPGFYSWRNTTRGSWF 267

Human   387 IEALAQVFSERACDMHVADMLVKV-NALIKDREGYAPGT-EFHRCKEMSEYCSTLCRHL 443
            :::|....:.....:.:..:|..| ..:..|.|...|.| |.|:.|::....:.|.|.|
  Fly   268 MQSLCAELAANGKRLDILTLLTFVCQRVAVDFESCTPDTPEMHQQKQIPCITTMLTRIL 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASP2	NP_116764.2	CARD_CASP2	32..118	CDD:260040
		CASc	192..447	CDD:214521	78/254 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	327..354		5/26 (19%)
Drice	NP_524551.2	CASc	86..330	CDD:214521	78/254 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10454
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910