DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CASP2 and Decay

DIOPT Version :9

Sequence 1:	NP_116764.2	Gene:	CASP2 / 835	HGNCID:	1503	Length:	452	Species:	Homo sapiens
Sequence 2:	NP_477462.1	Gene:	Decay / 42008	FlyBaseID:	FBgn0028381	Length:	308	Species:	Drosophila melanogaster

Alignment Length:	266	Identity:	70/266 - (26%)
Similarity:	124/266 - (46%)	Gaps:	39/266 - (14%)

- Green bases have known domain annotations that are detailed below.

Human   200 GLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQNFAQLPAH 264
            |:||:|::....|:|:   |.|.:.|...:....:..|:||....|.|..|:.:.|:..|: ..|
  Fly    56 GIALILNHKDVKGQKQ---RVGTERDRDDMEATLQGFGFDVRTFDDLTFSEINDTLKEVAR-EDH 116

Human   265 RVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLFDNANCPSLQNKPKMFFIQACRGDETDRGV 329
            ...|..::|::|||.||.:|..| ....::.::..|...||.:|:||||:||||||||...::.|
  Fly   117 SQNDCFVLAVMSHGTEGKVYAKD-MSYPVERLWNPFLGDNCKTLKNKPKLFFIQACRGANLEKAV 180

Human   330 DQQDGKNHAGSPGCEESDAG---KEKLPK---------MRLPTRSDMICGYACLKGTAAMRNTKR 382
                          |.|...   :|.:|:         ..:|:.:|::..|:......:.||...
  Fly   181 --------------EFSSFAVMTRELVPEPAAAVQPITYAIPSTADILVFYSTFDKFFSFRNVDD 231

Human   383 GSWYIEALAQVFSERACD-------MHVADMLVKVNALIK-DREGYAPGTEFHRCKEMSEYCSTL 439
            |||:|::|.:|..:.|.:       :.:..:|..||..:. :.:........::.|||..:.|||
  Fly   232 GSWFIQSLCRVLDQAAANEAATPEGVELLRLLTAVNRKVAYEYQSNTKNEALNQMKEMPNFMSTL 296

Human   440 CRHLYL 445
            .:...|
  Fly   297 TKTFQL 302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASP2	NP_116764.2	CARD_CASP2	32..118	CDD:260040
		CASc	192..447	CDD:214521	70/266 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	327..354		4/29 (14%)
Decay	NP_477462.1	CASc	54..302	CDD:237997	69/264 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152731
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740