DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CASP2 and Strica

DIOPT Version :9

Sequence 1:	NP_116764.2	Gene:	CASP2 / 835	HGNCID:	1503	Length:	452	Species:	Homo sapiens
Sequence 2:	NP_001260718.1	Gene:	Strica / 35528	FlyBaseID:	FBgn0033051	Length:	527	Species:	Drosophila melanogaster

Alignment Length:	219	Identity:	49/219 - (22%)
Similarity:	88/219 - (40%)	Gaps:	38/219 - (17%)

- Green bases have known domain annotations that are detailed below.

Human   209 HFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQNFAQLPAHRVTDSCIVA 273
            |...:.:.|||.|...|...|...|:.|...|.|:.|.|...: :|.....|........:.::.
  Fly   320 HERFDNKNEFRKGSAQDVKVLRATFEQLKCKVEVITDATLVTI-KKTVRMLQTKDFEDKSALVLV 383

Human   274 LLSHGVEGAIYGVDGKLLQLQEVFQLFDNANCPSLQN-----KPKMFFIQACRGDETDRGVDQQD 333
            :||||..      ..::....:.:.|.|:...|.|:|     |||:.|:|||:|| ...|....|
  Fly   384 ILSHGTR------HDQIAAKDDDYSLDDDVVFPILRNRTLKDKPKLIFVQACKGD-CQLGGFMTD 441

Human   334 GKNHAGSPGCEESDAGKEKLPKMRLPTRSDMICGYACLKGTAAMRNTKRGSWYIEALAQVFSERA 398
            .....|||                    ::::..|:..:|..:.| |:.|:.:|:.|.:..:...
  Fly   442 AAQPNGSP--------------------NEILKCYSTYEGFVSFR-TEDGTPFIQTLCEALNRSG 485

Human   399 CDMHVADMLVKVNALI----KDRE 418
            ....:..:::.|..::    |||:
  Fly   486 KTSDIDTIMMNVRQVVKMQSKDRQ 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASP2	NP_116764.2	CARD_CASP2	32..118	CDD:260040
		CASc	192..447	CDD:214521	49/219 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	327..354		5/26 (19%)
Strica	NP_001260718.1	CASc	311..523	CDD:294037	49/219 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810