DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KATNAL2 and Katnal2

DIOPT Version :9

Sequence 1:	NP_001340828.1	Gene:	KATNAL2 / 83473	HGNCID:	25387	Length:	564	Species:	Homo sapiens
Sequence 2:	NP_001355584.1	Gene:	Katnal2 / 71206	MGIID:	1924234	Length:	539	Species:	Mus musculus

Alignment Length:	540	Identity:	467/540 - (86%)
Similarity:	493/540 - (91%)	Gaps:	3/540 - (0%)

- Green bases have known domain annotations that are detailed below.

Human    27 MELSYQTLKFTHQAREACEMRTEARRKNLLILISHYLTQEGYIDTANALEQETKLGLRRFEVCDN 91
            |||||||||.|||||||.|||||||||||||||.||||||||:|.|.|||:||||||||||||||
Mouse     1 MELSYQTLKLTHQAREAYEMRTEARRKNLLILILHYLTQEGYMDAAKALEEETKLGLRRFEVCDN 65

Human    92 IDLETILMEYESYYFVKFQKYPKIVKKSSDTAENNLPQRSRGKTRRMMNDSCQNLPKINQQRPRS 156
            :||||||||||||||||||||||:|||:.|..|||||.||.||.:|:.||||||||||..|:.|.
Mouse    66 VDLETILMEYESYYFVKFQKYPKVVKKAPDPVENNLPSRSGGKNKRLTNDSCQNLPKICHQKSRP 130

Human   157 KTTAGKTGDTKSLNKEHPNQ--EVVDNTRLESANFGLHISRIRKDSGEENAHPRRGQIIDFQGLL 219
            ||:|.|||||||: |||..|  |.|.:|:.||.:|||:||:|.||..||.|.|||||||||:|||
Mouse   131 KTSAVKTGDTKSV-KEHLKQVKESVTDTQAESTDFGLNISKIHKDQPEEKAQPRRGQIIDFRGLL 194

Human   220 TDAIKGATSELALNTFDHNPDPSERLLKPLSAFIGMNSEMRELAAVVSRDIYLHNPNIKWNDIIG 284
            :|||||||||.|||||:.|||||||||||||||||||||||||||||||||||||||||||||||
Mouse   195 SDAIKGATSEFALNTFECNPDPSERLLKPLSAFIGMNSEMRELAAVVSRDIYLHNPNIKWNDIIG 259

Human   285 LDAAKQLVKEAVVYPIRYPQLFTGILSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTI 349
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   260 LDAAKQLVKEAVVYPIRYPQLFTGILSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTI 324

Human   350 VSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMSQRGTASGGEHEGSLRMKTELLVQMDGLA 414
            ||||||||||||||||||||||||||||||||||||||||...||||||||||||||||||||||
Mouse   325 VSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMSQRGMVPGGEHEGSLRMKTELLVQMDGLA 389

Human   415 RSEDLVFVLAASNLPWELDCAMLRRLEKRILVDLPSREARQAMIYHWLPPVSKSRALELHTELEY 479
            ||||||||||||||||||||||||||||||||||||:||||||||||||||||:.||||||:|||
Mouse   390 RSEDLVFVLAASNLPWELDCAMLRRLEKRILVDLPSQEARQAMIYHWLPPVSKNHALELHTQLEY 454

Human   480 SVLSQETEGYSGSDIKLVCREAAMRPVRKIFDALENHQSESSDLPRIQLDIVTTADFLDVLTHTK 544
            |||||||||||||||||||||||||||||||..|||:||||::||.||||.|||.||||||.|||
Mouse   455 SVLSQETEGYSGSDIKLVCREAAMRPVRKIFSVLENNQSESNNLPGIQLDTVTTQDFLDVLAHTK 519

Human   545 PSAKNLAQRYSDWQREFESV 564
            ||||||.:||..||.:||||
Mouse   520 PSAKNLTERYLAWQEKFESV 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KATNAL2	NP_001340828.1	LisH	51..81	CDD:128913	24/29 (83%)
KATNAL2	NP_001340828.1	SpoVK	<264..559	CDD:223540	274/294 (93%)
Katnal2	NP_001355584.1	LisH	25..55	CDD:128913	24/29 (83%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	93..121		17/27 (63%)
		SpoVK	<239..523	CDD:223540	267/283 (94%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83964856
Domainoid	1	1.000	384	1.000	Domainoid score	I11990
eggNOG	1	0.900	-	-		E1_COG0554
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41725
Inparanoid	1	1.050	917	1.000	Inparanoid score	I6608
Isobase	1	0.950	-	0	Normalized mean entropy	S1804
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG56531
OrthoDB	1	1.010	-	-		D211872at33208
OrthoFinder	1	1.000	-	-		FOG0006521
OrthoInspector	1	1.000	-	-		oto128367
orthoMCL	1	0.900	-	-		OOG6_103499
Panther	1	1.100	-	-	LDO	PTHR23074
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9098
SonicParanoid	1	1.000	-	-		X4752
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	20	20.250